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O83488

- G6PI_TREPA

UniProt

O83488 - G6PI_TREPA

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Protein
Glucose-6-phosphate isomerase
Gene
pgi, gpi, TP_0475
Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei359 – 3591Proton donor By similarity
Active sitei390 – 3901 By similarity
Active sitei505 – 5051 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-502-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Synonyms:gpi
Ordered Locus Names:TP_0475
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535Glucose-6-phosphate isomeraseUniRule annotation
PRO_0000180761Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243276.TP0475.

Structurei

3D structure databases

ProteinModelPortaliO83488.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiDLTFRFV.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83488-1 [UniParc]FASTAAdd to Basket

« Hide

MNWRNLDECA AYARLQAIRA PSLKTVLCGP EGIERVRRYC TDAGAGLRYH    50
YAAKTVNEEI LTALAALADE QELVAKYDAL RAGAQINTGE KRKVLHHLTR 100
LGVQGSSLAS LPCEVRDMHA FYTKEYERVC AFARQVHEGG LRTSRGAPFT 150
DVVQIGIGGS DLGPRALYLA LEGWAQRHQA VKMRTHFISN VDPDDAALVL 200
SKLPLETTLF ILVSKSGTTL ETLSNELFVA HVLRQAGLEP HTQFVAVTSE 250
TSPLANNPQY LASFYMDDFI GGRYSSSSVC GAVVLTLAFG PQVFGHFLSG 300
AAEADRAAQE QDIRRNAALL DALIGVYERT ILGYEHTAVL PYSQALARFP 350
AHLQQLDMES NGKSVNRFGI PITYKTGPVI FGEPGTNGQH SFYQHLHQGT 400
SVVPLQFIAF QHSQLGQDPI IRGSTGQQKL LANVVAQIVA FARGKEHADA 450
NKTFSGERPS SLLYAKALTP QTLGALLAHF ENKIMFQGFA WNLNSFDQEG 500
VQLGKTLAQH ILAGEVEGVL RAYADLFDLA HAPTC 535
Length:535
Mass (Da):58,418
Last modified:November 1, 1998 - v1
Checksum:i44C251C52ECEE33A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65462.1.
PIRiA71319.
RefSeqiNP_218916.1. NC_000919.1.
YP_008091322.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65462; AAC65462; TP_0475.
GeneIDi15851762.
2611115.
KEGGitpa:TP0475.
tpw:TPANIC_0475.
PATRICi20530975. VBITrePal57110_0507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65462.1 .
PIRi A71319.
RefSeqi NP_218916.1. NC_000919.1.
YP_008091322.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83488.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243276.TP0475.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65462 ; AAC65462 ; TP_0475 .
GeneIDi 15851762.
2611115.
KEGGi tpa:TP0475.
tpw:TPANIC_0475.
PATRICi 20530975. VBITrePal57110_0507.

Phylogenomic databases

eggNOGi COG0166.
KOi K01810.
OMAi DLTFRFV.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci TPAL243276:GC1H-502-MONOMER.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiG6PI_TREPA
AccessioniPrimary (citable) accession number: O83488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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