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O83488

- G6PI_TREPA

UniProt

O83488 - G6PI_TREPA

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei359 – 3591Proton donorBy similarity
    Active sitei390 – 3901By similarity
    Active sitei505 – 5051By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciTPAL243276:GC1H-502-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:pgi
    Synonyms:gpi
    Ordered Locus Names:TP_0475
    OrganismiTreponema pallidum (strain Nichols)
    Taxonomic identifieri243276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000000811: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 535535Glucose-6-phosphate isomerasePRO_0000180761Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243276.TP0475.

    Structurei

    3D structure databases

    ProteinModelPortaliO83488.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    KOiK01810.
    OMAiDLTFRFV.
    OrthoDBiEOG64R61J.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O83488-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNWRNLDECA AYARLQAIRA PSLKTVLCGP EGIERVRRYC TDAGAGLRYH    50
    YAAKTVNEEI LTALAALADE QELVAKYDAL RAGAQINTGE KRKVLHHLTR 100
    LGVQGSSLAS LPCEVRDMHA FYTKEYERVC AFARQVHEGG LRTSRGAPFT 150
    DVVQIGIGGS DLGPRALYLA LEGWAQRHQA VKMRTHFISN VDPDDAALVL 200
    SKLPLETTLF ILVSKSGTTL ETLSNELFVA HVLRQAGLEP HTQFVAVTSE 250
    TSPLANNPQY LASFYMDDFI GGRYSSSSVC GAVVLTLAFG PQVFGHFLSG 300
    AAEADRAAQE QDIRRNAALL DALIGVYERT ILGYEHTAVL PYSQALARFP 350
    AHLQQLDMES NGKSVNRFGI PITYKTGPVI FGEPGTNGQH SFYQHLHQGT 400
    SVVPLQFIAF QHSQLGQDPI IRGSTGQQKL LANVVAQIVA FARGKEHADA 450
    NKTFSGERPS SLLYAKALTP QTLGALLAHF ENKIMFQGFA WNLNSFDQEG 500
    VQLGKTLAQH ILAGEVEGVL RAYADLFDLA HAPTC 535
    Length:535
    Mass (Da):58,418
    Last modified:November 1, 1998 - v1
    Checksum:i44C251C52ECEE33A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65462.1.
    PIRiA71319.
    RefSeqiNP_218916.1. NC_000919.1.
    YP_008091322.1. NC_021490.2.

    Genome annotation databases

    EnsemblBacteriaiAAC65462; AAC65462; TP_0475.
    GeneIDi15851762.
    2611115.
    KEGGitpa:TP0475.
    tpw:TPANIC_0475.
    PATRICi20530975. VBITrePal57110_0507.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65462.1 .
    PIRi A71319.
    RefSeqi NP_218916.1. NC_000919.1.
    YP_008091322.1. NC_021490.2.

    3D structure databases

    ProteinModelPortali O83488.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243276.TP0475.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC65462 ; AAC65462 ; TP_0475 .
    GeneIDi 15851762.
    2611115.
    KEGGi tpa:TP0475.
    tpw:TPANIC_0475.
    PATRICi 20530975. VBITrePal57110_0507.

    Phylogenomic databases

    eggNOGi COG0166.
    KOi K01810.
    OMAi DLTFRFV.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci TPAL243276:GC1H-502-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nichols.

    Entry informationi

    Entry nameiG6PI_TREPA
    AccessioniPrimary (citable) accession number: O83488
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3