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O83488 (G6PI_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Synonyms:gpi
Ordered Locus Names:TP_0475
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length535 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 535535Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180761

Sites

Active site3591Proton donor By similarity
Active site3901 By similarity
Active site5051 By similarity

Sequences

Sequence LengthMass (Da)Tools
O83488 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 44C251C52ECEE33A

FASTA53558,418
        10         20         30         40         50         60 
MNWRNLDECA AYARLQAIRA PSLKTVLCGP EGIERVRRYC TDAGAGLRYH YAAKTVNEEI 

        70         80         90        100        110        120 
LTALAALADE QELVAKYDAL RAGAQINTGE KRKVLHHLTR LGVQGSSLAS LPCEVRDMHA 

       130        140        150        160        170        180 
FYTKEYERVC AFARQVHEGG LRTSRGAPFT DVVQIGIGGS DLGPRALYLA LEGWAQRHQA 

       190        200        210        220        230        240 
VKMRTHFISN VDPDDAALVL SKLPLETTLF ILVSKSGTTL ETLSNELFVA HVLRQAGLEP 

       250        260        270        280        290        300 
HTQFVAVTSE TSPLANNPQY LASFYMDDFI GGRYSSSSVC GAVVLTLAFG PQVFGHFLSG 

       310        320        330        340        350        360 
AAEADRAAQE QDIRRNAALL DALIGVYERT ILGYEHTAVL PYSQALARFP AHLQQLDMES 

       370        380        390        400        410        420 
NGKSVNRFGI PITYKTGPVI FGEPGTNGQH SFYQHLHQGT SVVPLQFIAF QHSQLGQDPI 

       430        440        450        460        470        480 
IRGSTGQQKL LANVVAQIVA FARGKEHADA NKTFSGERPS SLLYAKALTP QTLGALLAHF 

       490        500        510        520        530 
ENKIMFQGFA WNLNSFDQEG VQLGKTLAQH ILAGEVEGVL RAYADLFDLA HAPTC 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000520 Genomic DNA. Translation: AAC65462.1.
PIRA71319.
RefSeqNP_218916.1. NC_000919.1.
YP_008091322.1. NC_021490.2.

3D structure databases

ProteinModelPortalO83488.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243276.TP0475.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC65462; AAC65462; TP_0475.
GeneID15851762.
2611115.
KEGGtpa:TP0475.
tpw:TPANIC_0475.
PATRIC20530975. VBITrePal57110_0507.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
KOK01810.
OMADLTFRFV.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycTPAL243276:GC1H-502-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_TREPA
AccessionPrimary (citable) accession number: O83488
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways