O83488 (G6PI_TREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Synonyms:	gpi
Ordered Locus Names:	TP_0475

Organism

Treponema pallidum (strain Nichols) [Complete proteome] [HAMAP]

Taxonomic identifier

243276 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Spirochaetaceae › Treponema › Treponema pallidum › Treponema pallidum subsp. pallidum

Protein attributes

Sequence length	535 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 535	535	Glucose-6-phosphate isomerase HAMAP-Rule MF_00473		PRO_0000180761
Sites
	Active site	359	1	Proton donor By similarity
	Active site	390	1	By similarity
	Active site	505	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O83488 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 44C251C52ECEE33A	FASTA	535	58,418
	10 20 30 40 50 60 MNWRNLDECA AYARLQAIRA PSLKTVLCGP EGIERVRRYC TDAGAGLRYH YAAKTVNEEI 70 80 90 100 110 120 LTALAALADE QELVAKYDAL RAGAQINTGE KRKVLHHLTR LGVQGSSLAS LPCEVRDMHA 130 140 150 160 170 180 FYTKEYERVC AFARQVHEGG LRTSRGAPFT DVVQIGIGGS DLGPRALYLA LEGWAQRHQA 190 200 210 220 230 240 VKMRTHFISN VDPDDAALVL SKLPLETTLF ILVSKSGTTL ETLSNELFVA HVLRQAGLEP 250 260 270 280 290 300 HTQFVAVTSE TSPLANNPQY LASFYMDDFI GGRYSSSSVC GAVVLTLAFG PQVFGHFLSG 310 320 330 340 350 360 AAEADRAAQE QDIRRNAALL DALIGVYERT ILGYEHTAVL PYSQALARFP AHLQQLDMES 370 380 390 400 410 420 NGKSVNRFGI PITYKTGPVI FGEPGTNGQH SFYQHLHQGT SVVPLQFIAF QHSQLGQDPI 430 440 450 460 470 480 IRGSTGQQKL LANVVAQIVA FARGKEHADA NKTFSGERPS SLLYAKALTP QTLGALLAHF 490 500 510 520 530 ENKIMFQGFA WNLNSFDQEG VQLGKTLAQH ILAGEVEGVL RAYADLFDLA HAPTC

References

[1]

"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000520 Genomic DNA. Translation: AAC65462.1.
PIR	A71319.
RefSeq	NP_218916.1. NC_000919.1.
3D structure databases
ProteinModelPortal	O83488.
ModBase	Search...
Protein-protein interaction databases
STRING	243276.TP0475.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC65462; AAC65462; TP_0475.
GeneID	2611115.
KEGG	tpa:TP0475.
PATRIC	20530975. VBITrePal57110_0507.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
KO	K01810.
OMA	KKFNRNG.
ProtClustDB	PRK14095.
Enzyme and pathway databases
UniPathway	UPA00109; UER00181.
Family and domain databases
Gene3D	1.10.1390.10. 1 hit.
HAMAP	MF_00473. G6P_isomerase.
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. PTHR11469. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. False negative. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_TREPA

Accession

Primary (citable) accession number: O83488

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program