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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei359 – 3591Proton donorBy similarity
Active sitei390 – 3901By similarity
Active sitei505 – 5051By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-502-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Synonyms:gpi
Ordered Locus Names:TP_0475
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811 Componenti: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535Glucose-6-phosphate isomerasePRO_0000180761Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243276.TP0475.

Structurei

3D structure databases

ProteinModelPortaliO83488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWRNLDECA AYARLQAIRA PSLKTVLCGP EGIERVRRYC TDAGAGLRYH
60 70 80 90 100
YAAKTVNEEI LTALAALADE QELVAKYDAL RAGAQINTGE KRKVLHHLTR
110 120 130 140 150
LGVQGSSLAS LPCEVRDMHA FYTKEYERVC AFARQVHEGG LRTSRGAPFT
160 170 180 190 200
DVVQIGIGGS DLGPRALYLA LEGWAQRHQA VKMRTHFISN VDPDDAALVL
210 220 230 240 250
SKLPLETTLF ILVSKSGTTL ETLSNELFVA HVLRQAGLEP HTQFVAVTSE
260 270 280 290 300
TSPLANNPQY LASFYMDDFI GGRYSSSSVC GAVVLTLAFG PQVFGHFLSG
310 320 330 340 350
AAEADRAAQE QDIRRNAALL DALIGVYERT ILGYEHTAVL PYSQALARFP
360 370 380 390 400
AHLQQLDMES NGKSVNRFGI PITYKTGPVI FGEPGTNGQH SFYQHLHQGT
410 420 430 440 450
SVVPLQFIAF QHSQLGQDPI IRGSTGQQKL LANVVAQIVA FARGKEHADA
460 470 480 490 500
NKTFSGERPS SLLYAKALTP QTLGALLAHF ENKIMFQGFA WNLNSFDQEG
510 520 530
VQLGKTLAQH ILAGEVEGVL RAYADLFDLA HAPTC
Length:535
Mass (Da):58,418
Last modified:November 1, 1998 - v1
Checksum:i44C251C52ECEE33A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65462.1.
PIRiA71319.
RefSeqiNP_218916.1. NC_000919.1.
YP_008091322.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65462; AAC65462; TP_0475.
KEGGitpa:TP0475.
tpw:TPANIC_0475.
PATRICi20530975. VBITrePal57110_0507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65462.1.
PIRiA71319.
RefSeqiNP_218916.1. NC_000919.1.
YP_008091322.1. NC_021490.2.

3D structure databases

ProteinModelPortaliO83488.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243276.TP0475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65462; AAC65462; TP_0475.
KEGGitpa:TP0475.
tpw:TPANIC_0475.
PATRICi20530975. VBITrePal57110_0507.

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciTPAL243276:GC1H-502-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiG6PI_TREPA
AccessioniPrimary (citable) accession number: O83488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1998
Last modified: April 1, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.