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O83477

- TRMB_TREPA

UniProt

O83477 - TRMB_TREPA

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861S-adenosyl-L-methionineUniRule annotation
    Binding sitei111 – 1111S-adenosyl-L-methionineUniRule annotation
    Binding sitei138 – 1381S-adenosyl-L-methionineUniRule annotation
    Active sitei161 – 1611By similarity
    Binding sitei161 – 1611S-adenosyl-L-methionineUniRule annotation
    Binding sitei165 – 1651SubstrateUniRule annotation
    Binding sitei197 – 1971SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciTPAL243276:GC1H-491-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:TP_0464
    OrganismiTreponema pallidum (strain Nichols)
    Taxonomic identifieri243276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000000811: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250tRNA (guanine-N(7)-)-methyltransferasePRO_0000171416Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiO83477. 4 interactions.
    MINTiMINT-6479630.
    STRINGi243276.TP0464.

    Structurei

    3D structure databases

    ProteinModelPortaliO83477.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni229 – 2324Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    KOiK03439.
    OMAiMSTENEN.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O83477-1 [UniParc]FASTAAdd to Basket

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    MTNDSARMRK VLTFTRRSNR MTACQKRDYQ HLASRWIIPY QNTVFDYAAV    50
    FCSPAAPSAP AGAFPAPQGK TDAVAPACAP APLVVEIGFG MGSATAAIAA 100
    RNPHLSYLGI EVYRAGIGRL LRKIEAERLH NLRIIEHDAL DVLRTMIAPQ 150
    TLAGLHIFFP DPWPKTRHHK RRLLYRPRTD LLARALAPGG YLYAVTDWAE 200
    YARRAQEELA RTPSLTWAPQ GARPWRPATE FERKAQTQGR AIHELFFIKA 250
    Length:250
    Mass (Da):28,068
    Last modified:November 1, 1998 - v1
    Checksum:iC5A227F4E4D15CC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65448.1.
    PIRiB71321.
    RefSeqiNP_218905.1. NC_000919.1.
    YP_008091312.1. NC_021490.2.

    Genome annotation databases

    EnsemblBacteriaiAAC65448; AAC65448; TP_0464.
    GeneIDi15851752.
    2611075.
    KEGGitpa:TP0464.
    tpw:TPANIC_0464.
    PATRICi20530953. VBITrePal57110_0496.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65448.1 .
    PIRi B71321.
    RefSeqi NP_218905.1. NC_000919.1.
    YP_008091312.1. NC_021490.2.

    3D structure databases

    ProteinModelPortali O83477.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O83477. 4 interactions.
    MINTi MINT-6479630.
    STRINGi 243276.TP0464.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC65448 ; AAC65448 ; TP_0464 .
    GeneIDi 15851752.
    2611075.
    KEGGi tpa:TP0464.
    tpw:TPANIC_0464.
    PATRICi 20530953. VBITrePal57110_0496.

    Phylogenomic databases

    eggNOGi COG0220.
    KOi K03439.
    OMAi MSTENEN.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci TPAL243276:GC1H-491-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nichols.

    Entry informationi

    Entry nameiTRMB_TREPA
    AccessioniPrimary (citable) accession number: O83477
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3