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O83477

- TRMB_TREPA

UniProt

O83477 - TRMB_TREPA

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, TP_0464
Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861S-adenosyl-L-methionine By similarity
Binding sitei111 – 1111S-adenosyl-L-methionine By similarity
Binding sitei138 – 1381S-adenosyl-L-methionine By similarity
Active sitei161 – 1611 By similarity
Binding sitei161 – 1611S-adenosyl-L-methionine By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei197 – 1971Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-491-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:TP_0464
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000171416Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiO83477. 4 interactions.
MINTiMINT-6479630.
STRINGi243276.TP0464.

Structurei

3D structure databases

ProteinModelPortaliO83477.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni229 – 2324Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiMSTENEN.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83477-1 [UniParc]FASTAAdd to Basket

« Hide

MTNDSARMRK VLTFTRRSNR MTACQKRDYQ HLASRWIIPY QNTVFDYAAV    50
FCSPAAPSAP AGAFPAPQGK TDAVAPACAP APLVVEIGFG MGSATAAIAA 100
RNPHLSYLGI EVYRAGIGRL LRKIEAERLH NLRIIEHDAL DVLRTMIAPQ 150
TLAGLHIFFP DPWPKTRHHK RRLLYRPRTD LLARALAPGG YLYAVTDWAE 200
YARRAQEELA RTPSLTWAPQ GARPWRPATE FERKAQTQGR AIHELFFIKA 250
Length:250
Mass (Da):28,068
Last modified:November 1, 1998 - v1
Checksum:iC5A227F4E4D15CC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65448.1.
PIRiB71321.
RefSeqiNP_218905.1. NC_000919.1.
YP_008091312.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65448; AAC65448; TP_0464.
GeneIDi15851752.
2611075.
KEGGitpa:TP0464.
tpw:TPANIC_0464.
PATRICi20530953. VBITrePal57110_0496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65448.1 .
PIRi B71321.
RefSeqi NP_218905.1. NC_000919.1.
YP_008091312.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83477.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O83477. 4 interactions.
MINTi MINT-6479630.
STRINGi 243276.TP0464.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65448 ; AAC65448 ; TP_0464 .
GeneIDi 15851752.
2611075.
KEGGi tpa:TP0464.
tpw:TPANIC_0464.
PATRICi 20530953. VBITrePal57110_0496.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OMAi MSTENEN.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci TPAL243276:GC1H-491-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiTRMB_TREPA
AccessioniPrimary (citable) accession number: O83477
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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