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O83455 (NADK_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:TP_0441
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305NAD kinase HAMAP-Rule MF_00361
PRO_0000120682

Regions

Nucleotide binding76 – 772NAD By similarity
Nucleotide binding150 – 1512NAD By similarity

Sites

Active site761Proton acceptor By similarity
Binding site1611NAD By similarity
Binding site1801NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
O83455 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 4885B3DDE3C1CE58

FASTA30532,634
        10         20         30         40         50         60 
MSSRVCPQRP VAKSSGDAKV LLIVSTYKPR AAVLAADVVN FLSIRGFQCH TIEYDGLNKE 

        70         80         90        100        110        120 
SCARAGYMFA VSIGGDGTTL FAARCASPSG IPILAINLGR FGFIAPIEPR YWQQALSDYL 

       130        140        150        160        170        180 
AGGVRPAERA LISCTVTRAG KEIASCLALN DVVLSSGRVA RLTRAEVCFN DISFGVYEAD 

       190        200        210        220        230        240 
GIILATPTGS TAYSAACGGP ILDPDLDAFV LTPISALCLS NRPVVVPSSG VVRIKVLSMR 

       250        260        270        280        290        300 
HKETVLSVDG HELCTLQEED QLLASRSSCS ARLVFCTPHV FYHALCSKLA WSGSIFSRRG 


RRHDD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000520 Genomic DNA. Translation: AAC65428.1.
PIRA71324.
RefSeqNP_218881.1. NC_000919.1.
YP_008091289.1. NC_021490.2.

3D structure databases

ProteinModelPortalO83455.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO83455. 1 interaction.
STRING243276.TP0441.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC65428; AAC65428; TP_0441.
GeneID15851729.
2610985.
KEGGtpa:TP0441.
tpw:TPANIC_0441.
PATRIC20530901. VBITrePal57110_0470.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
KOK00858.
OMAGAEFCLN.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycTPAL243276:GC1H-467-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_TREPA
AccessionPrimary (citable) accession number: O83455
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families