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O83455

- NADK_TREPA

UniProt

O83455 - NADK_TREPA

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Protein
NAD kinase
Gene
nadK, TP_0441
Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Proton acceptor By similarity
Binding sitei161 – 1611NAD By similarity
Binding sitei180 – 1801NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi76 – 772NAD By similarity
Nucleotide bindingi150 – 1512NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-467-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:TP_0441
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305NAD kinaseUniRule annotation
PRO_0000120682Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiO83455. 1 interaction.
STRINGi243276.TP0441.

Structurei

3D structure databases

ProteinModelPortaliO83455.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiGAEFCLN.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

O83455-1 [UniParc]FASTAAdd to Basket

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MSSRVCPQRP VAKSSGDAKV LLIVSTYKPR AAVLAADVVN FLSIRGFQCH    50
TIEYDGLNKE SCARAGYMFA VSIGGDGTTL FAARCASPSG IPILAINLGR 100
FGFIAPIEPR YWQQALSDYL AGGVRPAERA LISCTVTRAG KEIASCLALN 150
DVVLSSGRVA RLTRAEVCFN DISFGVYEAD GIILATPTGS TAYSAACGGP 200
ILDPDLDAFV LTPISALCLS NRPVVVPSSG VVRIKVLSMR HKETVLSVDG 250
HELCTLQEED QLLASRSSCS ARLVFCTPHV FYHALCSKLA WSGSIFSRRG 300
RRHDD 305
Length:305
Mass (Da):32,634
Last modified:November 1, 1998 - v1
Checksum:i4885B3DDE3C1CE58
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65428.1.
PIRiA71324.
RefSeqiNP_218881.1. NC_000919.1.
YP_008091289.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65428; AAC65428; TP_0441.
GeneIDi15851729.
2610985.
KEGGitpa:TP0441.
tpw:TPANIC_0441.
PATRICi20530901. VBITrePal57110_0470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65428.1 .
PIRi A71324.
RefSeqi NP_218881.1. NC_000919.1.
YP_008091289.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83455.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O83455. 1 interaction.
STRINGi 243276.TP0441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65428 ; AAC65428 ; TP_0441 .
GeneIDi 15851729.
2610985.
KEGGi tpa:TP0441.
tpw:TPANIC_0441.
PATRICi 20530901. VBITrePal57110_0470.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi GAEFCLN.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci TPAL243276:GC1H-467-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiNADK_TREPA
AccessioniPrimary (citable) accession number: O83455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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