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Protein

Putative galactokinase

Gene

galK

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).By similarity

Catalytic activityi

ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate.

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei38 – 381Transition state stabilizerBy similarity
Binding sitei78 – 781ATPBy similarity
Active sitei182 – 1821Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Galactose metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-444-MONOMER.
UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative galactokinase (EC:2.7.1.6)
Alternative name(s):
Galactose kinase
Gene namesi
Name:galK
Ordered Locus Names:TP_0418
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Putative galactokinasePRO_0000184634Add
BLAST

Proteomic databases

PRIDEiO83433.

Interactioni

Protein-protein interaction databases

IntActiO83433. 9 interactions.
STRINGi243276.TP0418.

Structurei

3D structure databases

ProteinModelPortaliO83433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. GalK subfamily.Curated

Phylogenomic databases

eggNOGiENOG41080VC. Bacteria.
COG0153. LUCA.
KOiK00849.
OMAiDKALACQ.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
InterProiIPR000705. Galactokinase.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 1 hit.
PfamiPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000530. Galactokinase. 1 hit.
PRINTSiPR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.

Sequencei

Sequence statusi: Complete.

O83433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYYFNTLAM MLRMQRVESC HTEEYGDEPE AIAVVPGRFH LLGEYLWFAQ
60 70 80 90 100
GNTLSMAIDQ TLTLCVSRRK DSTFRLFSLT LGERRKISTA NLRYRKEDRW
110 120 130 140 150
ANSVKAVILS FMDGGYHLTG LNCTILSQIP PDAGLGTPNA LKVAMALVLG
160 170 180 190 200
RLFAATLPKE SVVSIVEHAN ERYLKTHAHR ADILCVLFAK QGSCVRTDHR
210 220 230 240 250
KKQAELCQFP SEGKRIVLTD SRVPRFIARE EFTARLKRCV DAYELVKRNP
260 270 280 290 300
DMPRAMSKLM AAALEEIDVP EGIRRRVISL VRESLGVDEA IEALRKRDFA
310 320 330 340 350
AFSRVVNRSH ERLRDRFEIS CPELDWLVKR ALEFVDPDAP DVVCSRLTGR
360 370 380 390
GFGGCTYAIL RDQDFEPYLE RLDEYERIFG FKAAAYEVQC SEGARVL
Length:397
Mass (Da):45,255
Last modified:November 1, 1998 - v1
Checksum:iA86D102B89C6FB6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65405.1.
PIRiH71327.

Genome annotation databases

EnsemblBacteriaiAAC65405; AAC65405; TP_0418.
KEGGitpa:TP_0418.
PATRICi20530849. VBITrePal57110_0444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65405.1.
PIRiH71327.

3D structure databases

ProteinModelPortaliO83433.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO83433. 9 interactions.
STRINGi243276.TP0418.

Proteomic databases

PRIDEiO83433.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65405; AAC65405; TP_0418.
KEGGitpa:TP_0418.
PATRICi20530849. VBITrePal57110_0444.

Phylogenomic databases

eggNOGiENOG41080VC. Bacteria.
COG0153. LUCA.
KOiK00849.
OMAiDKALACQ.

Enzyme and pathway databases

UniPathwayiUPA00214.
BioCyciTPAL243276:GC1H-444-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
InterProiIPR000705. Galactokinase.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 1 hit.
PfamiPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000530. Galactokinase. 1 hit.
PRINTSiPR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGAL1_TREPA
AccessioniPrimary (citable) accession number: O83433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.