O83401 (MURF_TREPA) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 81.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase EC=6.3.2.10 Alternative name(s): D-alanyl-D-alanine-adding enzyme UDP-MurNAc-pentapeptide synthetase | ||||
| Gene names |
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| Organism | Treponema pallidum (strain Nichols) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 243276 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema |
Protein attributes
| Sequence length | 459 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity. |
| Catalytic activity | ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine. |
| Pathway | |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the MurCDEF family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| [1] | "Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. Venter J.C.Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE000520 Genomic DNA. Translation: AAC65370.1. |
| PIR | D71331. |
| RefSeq | NP_218826.1. NC_000919.1. |
3D structure databases | |
| ProteinModelPortal | O83401. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O83401. 1 interaction. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2611288. |
| GenomeReviews | Gene locus TP_0386 in contig AE000520_GR. |
| KEGG | tpa:TP0386. |
| NMPDR | fig|243276.1.peg.385. |
| PATRIC | 20530781. VBITrePal57110_0410. |
| TIGR | TP_0386. |
Phylogenomic databases | |
| HOGENOM | HBG617121. |
| OMA | YAVIEMG. |
| ProtClustDB | CLSK218674. |
Enzyme and pathway databases | |
| BioCyc | TPAL243276:TP_0386-MONOMER. |
Family and domain databases | |
| InterPro | IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR005863. UDP-N-AcMur-pentapeptide_synth. [Graphical view] |
| Gene3D | G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. |
| KO | K01929. |
| PANTHER | PTHR23135:SF3. MurF. 1 hit. |
| Pfam | PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view] |
| SUPFAM | SSF53244. Mur_ligase_C. 1 hit. SSF53623. Mur_ligase_cen. 1 hit. |
| TIGRFAMs | TIGR01143. MurF. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MURF_TREPA | ||||||||
| Accession | Primary (citable) accession number: O83401 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with