Reviewed,
UniProtKB/Swiss-Prot O83401 (MURF_TREPA)
Last modified
June 16, 2009.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase EC=6.3.2.10 Alternative name(s): UDP-MurNAc-pentapeptide synthetase D-alanyl-D-alanine-adding enzyme | ||||
| Gene names |
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| Organism | Treponema pallidum [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 160 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema |
Protein attributes
| Sequence length | 459 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity. |
| Catalytic activity | ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine. |
| Pathway | |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the murCDEF family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| [1] | "Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. Venter J.C.Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols. |
Cross-references
Sequence databases | |
|---|---|
| AE000520 Genomic DNA. Translation: AAC65370.1. | |
| PIR | D71331. |
| RefSeq | NP_218826.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GG4 based on UniProtKB P11880. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O83401. 1 interaction. |
Genome annotation databases | |
| GeneID | 2611288. |
| GenomeReviews | Gene locus TP_0386 in contig AE000520_GR. |
| KEGG | tpa:TP0386. |
| NMPDR | fig|243276.1.peg.385. |
| TIGR | TP_0386. |
Phylogenomic databases | |
| HOGENOM | O83401. |
| OMA | O83401. LDDTYNA. |
Enzyme and pathway databases | |
| BioCyc | TPAL243276:TP_0386-MON. |
| BRENDA | 6.3.2.10. 142600. |
Family and domain databases | |
| InterPro | IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR005863. UDP-N-AcMur-3pep_AlaAla_ligase. [Graphical view] |
| Gene3D | G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. |
| PANTHER | PTHR23135:SF3. MurF. 1 hit. |
| Pfam | PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01143. murF. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MURF_TREPA | ||||||||
| Accession | Primary (citable) accession number: O83401 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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