Reviewed, UniProtKB/Swiss-Prot O83373 (KTHY_TREPA)

Names and origin

Protein names

Recommended name:
    Putative thymidylate kinase
    EC=2.7.4.9
Alternative name(s):
    dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	TP_0354

Organism

Treponema pallidum [Complete proteome] [HAMAP]

Taxonomic identifier

160 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.
Caution	Could be inactive due to a defective ATP-binding site.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Putative thymidylate kinase HAMAP MF_00165		PRO_0000155363
Regions
	Region	12 – 19	8	Defective ATP-binding Potential

Sequences

	Sequence		Length	Mass (Da)
	O83373-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: E0186BAF9949896D	FASTA	208	23,948
	10 20 30 40 50 60 MNILHNFVVF EGIDGTGTST QLRALERHFQ ARKDMVFTQE PTGGEIGTLI RDVLQKRVIM 70 80 90 100 110 120 SSKALGLLFA ADRHEHLEGA GGINDCLAEG KIVLCDRYVF SSLVYQGMAV SGSFAYELNK 130 140 150 160 170 180 EFPLPEVVFY FDAPIEVCVE RITARGLQTE LYEYTSFQEK ARKGYETIFR KCRHLYPAMK 190 200 VIEIDAREEI EVVHERILHH LREYRRLK

References

[1]

"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000520 Genomic DNA. Translation: AAC65341.1.
PIR	H71333.
RefSeq	NP_218794.1.
3D structure databases
SMR	O83373. Positions 6-196.
ModBase	Search...
Protein-protein interaction databases
IntAct	O83373. 11 interactions.
Genome annotation databases
GeneID	2611500.
GenomeReviews	Gene locus TP_0354 in contig AE000520_GR.
KEGG	tpa:TP0354.
NMPDR	fig|243276.1.peg.353.
TIGR	TP_0354.
Phylogenomic databases
HOGENOM	HBG626009.
OMA	FTFEPTD.
Enzyme and pathway databases
BioCyc	TPAL243276:TP_0354-MONOMER.
BRENDA	2.7.4.9. 142600.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase. Divergent sequence. [Tree]
InterPro	IPR018094. Thymidylate_kin. IPR000062. Thymidylate_kin-like. IPR018095. Thymidylate_kin_CS. [Graphical view]
PANTHER	PTHR10344. Thymidylate_kin. 1 hit.
Pfam	PF02223. Thymidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_TREPA

Accession

Primary (citable) accession number: O83373

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	November 1, 1998
Last modified:	February 9, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)