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O83351

- 6PGD_TREPA

UniProt

O83351 - 6PGD_TREPA

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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene
gnd, TP_0331
Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021NADP By similarity
Binding sitei102 – 1021Substrate By similarity
Active sitei183 – 1831Proton acceptor By similarity
Active sitei190 – 1901Proton donor By similarity
Binding sitei191 – 1911Substrate By similarity
Binding sitei260 – 2601Substrate; via amide nitrogen By similarity
Binding sitei287 – 2871Substrate By similarity
Binding sitei451 – 4511Substrate; shared with dimeric partner By similarity
Binding sitei457 – 4571Substrate; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146NADP By similarity
Nucleotide bindingi32 – 343NADP By similarity
Nucleotide bindingi74 – 763NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-356-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:TP_0331
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4884886-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090062Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi243276.TP0331.

Structurei

3D structure databases

ProteinModelPortaliO83351.
SMRiO83351. Positions 1-475.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 1303Substrate binding By similarity
Regioni186 – 1872Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
KOiK00033.
OMAiRVASENY.
OrthoDBiEOG6MSS4W.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83351-1 [UniParc]FASTAAdd to Basket

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MGADIGFIGL AVMGENLVLN IERNGFSVAV FNRTTTVVDR FLAGRAHGKR    50
ITGAHSIAEL VSLLARPRKI MLMVKAGSAV DAVIDQILPL LEKGDLVIDG 100
GNSHYQDTIR RMHALEAAGI HFIGTGVSGG EEGALRGPSL MPGGSAQAWP 150
LVSPIFCAIA AKADDGTPCC DWVGSDGAGH YVKMIHNGIE YGDMQIIAEG 200
YWFMKHALGM SYEHMHHTFT RWNTGRLHSY LIEITAAILA HQDTDGTPLL 250
EKILDAAGQK GTGRWTCVAA LEEGSPLTLI TESVMARSLS AQKQARCKAH 300
RVFGSPVKVS KAETLSAQQR EELVSALEDA LYCAKIVSYA QGFELLSHTA 350
KRRGWTLDFS RIASLWRGGC IIRSGFLSKI SAAFAQQHDL ENLVLAPFFA 400
EELKRACPGW RTIVAESVRQ ALPVPALSAA LAWFDGFTGA ALPANLLQAQ 450
RDYFGAHTYE RTDAPRGEFF HTNWTGTGGD TIAGTYSI 488
Length:488
Mass (Da):52,767
Last modified:November 1, 1998 - v1
Checksum:iFB69CCCA98DEE6B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65319.1.
PIRiA71337.
RefSeqiNP_218771.1. NC_000919.1.
YP_008091185.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65319; AAC65319; TP_0331.
GeneIDi15851624.
2611604.
KEGGitpa:TP0331.
tpw:TPANIC_0331.
PATRICi20530653. VBITrePal57110_0347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65319.1 .
PIRi A71337.
RefSeqi NP_218771.1. NC_000919.1.
YP_008091185.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83351.
SMRi O83351. Positions 1-475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243276.TP0331.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65319 ; AAC65319 ; TP_0331 .
GeneIDi 15851624.
2611604.
KEGGi tpa:TP0331.
tpw:TPANIC_0331.
PATRICi 20530653. VBITrePal57110_0347.

Phylogenomic databases

eggNOGi COG0362.
KOi K00033.
OMAi RVASENY.
OrthoDBi EOG6MSS4W.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci TPAL243276:GC1H-356-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry namei6PGD_TREPA
AccessioniPrimary (citable) accession number: O83351
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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