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O83269 (RPOB_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA-directed RNA polymerase subunit beta
Short name=RNAP subunit beta
EC=2.7.7.6
Alternative name(s):
RNA polymerase subunit beta
Transcriptase subunit beta
Gene names
Name:rpoB
Ordered Locus Names:TP_0241
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length1178 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_01321

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_01321

Subunit structure

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.

Sequence similarities

Belongs to the RNA polymerase beta chain family.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentDNA-directed RNA polymerase
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionDNA binding

Inferred from electronic annotation. Source: InterPro

DNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

ribonucleoside binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11781178DNA-directed RNA polymerase subunit beta HAMAP MF_01321
PRO_0000047987

Sequences

Sequence LengthMass (Da)Tools
O83269 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: E429EF184B5DB997

FASTA1,178132,447
        10         20         30         40         50         60 
MSARVCKTHR VYVGRDVRNF MDIPDLIEIQ LRSYDTFLHG ARNTPSGADT LISGTREELG 

        70         80         90        100        110        120 
LEDVFKTTFP IESSTGDMTL EYQSYSLDEK NIKFSEAECK QKGLTYAIPL KALVDLRFNN 

       130        140        150        160        170        180 
TGEIRRKDIY MGDIPKMTER GTFIINGAER VVVSQIHRSP GVVFSHEKDK EGREVFSSRI 

       190        200        210        220        230        240 
IPYRGSWLEF EIDQKKDLIY AKLDKKRRIL GTVFLRALHY ETREQIIEAF YAIEKTPVCQ 

       250        260        270        280        290        300 
DRAEYELLTG KILARSVTVE NEQGETRVLY KAGEKIHPHV IDDLLQNGIC EVYIINLEAE 

       310        320        330        340        350        360 
GSLRSAVVIN CLEREEMKFS KSGAQDELSR EEALCIVYSA LRPSDPMTMD AAEKDLQTMF 

       370        380        390        400        410        420 
FSPRRYDLGR VGRYKLNKKF RSDSPTTECT LTLDDIVNTM KFLIRMYSGD AQEDDIDHLG 

       430        440        450        460        470        480 
NRRIRSVGEL MTNTLKTAFL RMERIAKERM SSKETETIKP QDLISIKPIM AAIKEFFGAS 

       490        500        510        520        530        540 
QLSQFMDQVN PLAELTHKRR LNALGPGGLS RERAGFEVRD VHYTHYGRMC PIETPEGPNI 

       550        560        570        580        590        600 
GLIVSMANYA RVNGYGFLEV PYVRVRDGVV TKEIEYLDAM DEDRYYIGQD STAVGPDGVI 

       610        620        630        640        650        660 
RVDHVSCRHR GDYSTRSPKD IQYMDVSPKQ IISVSASLIP FLEHDDANRA LMGSNMQRQG 

       670        680        690        700        710        720 
VPLIFPEPPR VGTGMEEKCA YDSGVLVKAK QDGTVAYVSS EKIVVCSAAA SGEEQEVVYP 

       730        740        750        760        770        780 
LLKYQRTNQD TCYHQRPIVH VGDRVQVGDA LADGPATYRG ELALGRNILV GFVPWNGYNY 

       790        800        810        820        830        840 
EDAILISHRV VKEDMFTSVH IKEFSTEVRE TKLGSERMTN DIPNKSEKNL DNLDAEGIIR 

       850        860        870        880        890        900 
IGSKVRAGDV LIGKITPKSE SETTPEFRLL NSIFGEKAKE VRDSSLRVPH GVEGTVIDVQ 

       910        920        930        940        950        960 
RLRRSEGDDL NPGVSEVVKV LIATKRKLRE GDKMAGRHGN KGIVARILPE EDMPYLDDGT 

       970        980        990       1000       1010       1020 
PLDVCLNPLG VPSRMNIGQI LESELGLAGL RLDEWYESPV FQSPSNEQIG EKLMQAGFPT 

      1030       1040       1050       1060       1070       1080 
NSKVMLRDGR TGDYFQNPVF VGVIYFMKLA HLVDDKMHAR STGPYSLVTQ QPLGGKAQFG 

      1090       1100       1110       1120       1130       1140 
GQRLGEMEVW ALEAYGAANT LQELLTIKSD DMHGRSKIYE AIVKGEASSP TGIPESFNVL 

      1150       1160       1170 
VQELRGLALD FTIYDAKGKQ IPLTERDEEM TNKIGSKF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000520 Genomic DNA. Translation: AAC65229.1.
PIRC71350.
RefSeqNP_218681.1. NC_000919.1.

3D structure databases

ProteinModelPortalO83269.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2611158.
GenomeReviewsGene locus TP_0241 in contig AE000520_GR.
KEGGtpa:TP0241.
NMPDRfig|243276.1.peg.240.
PATRIC20530469. VBITrePal57110_0260.
TIGRTP_0241.

Phylogenomic databases

HOGENOMHBG285547.
OMAHANEEIT.
ProtClustDBPRK00405.

Enzyme and pathway databases

BioCycTPAL243276:TP_0241-MONOMER.

Family and domain databases

HAMAPMF_01321. RNApol_bact_RpoB.
[Tree]
InterProIPR010243. DNA-dir_RNA_pol_bsu_bac-type.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
Gene3DG3DSA:2.30.150.10. G3DSA:2.30.150.10. 1 hit.
G3DSA:2.40.270.10. G3DSA:2.40.270.10. 2 hits.
G3DSA:2.40.50.150. Ribosomal_L2. 1 hit.
KOK03043.
PANTHERPTHR20856:SF3. PTHR20856:SF3. 1 hit.
PTHR20856. RNA_pol_I_sub2. 1 hit.
PfamPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsTIGR02013. RpoB. 1 hit.
PROSITEPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPOB_TREPA
AccessionPrimary (citable) accession number: O83269
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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