ID   O83248_TREPA            Unreviewed;       715 AA.
AC   O83248;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   27-MAR-2024, entry version 114.
DE   SubName: Full=Sigma factor SigG regulation protein, putative {ECO:0000313|EMBL:AAC65206.1};
GN   OrderedLocusNames=TP_0219 {ECO:0000313|EMBL:AAC65206.1};
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65206.1, ECO:0000313|Proteomes:UP000000811};
RN   [1] {ECO:0000313|EMBL:AAC65206.1, ECO:0000313|Proteomes:UP000000811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols {ECO:0000313|EMBL:AAC65206.1,
RC   ECO:0000313|Proteomes:UP000000811};
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA   Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA   Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA   Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA   Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA   Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
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DR   EMBL; AE000520; AAC65206.1; -; Genomic_DNA.
DR   PIR; H71352; H71352.
DR   RefSeq; WP_010881667.1; NC_021490.2.
DR   AlphaFoldDB; O83248; -.
DR   STRING; 243276.TP_0219; -.
DR   EnsemblBacteria; AAC65206; AAC65206; TP_0219.
DR   GeneID; 57878757; -.
DR   KEGG; tpa:TP_0219; -.
DR   PATRIC; fig|243276.9.peg.223; -.
DR   eggNOG; COG2208; Bacteria.
DR   HOGENOM; CLU_023575_0_0_12; -.
DR   OrthoDB; 9773346at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000811};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        31..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        62..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        96..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        139..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        175..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        204..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        238..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        263..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          488..711
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|SMART:SM00331"
SQ   SEQUENCE   715 AA;  81440 MW;  AB69F260F326E02D CRC64;
     MGLLFFSYLF VAVFVFDVFC LKFYTRRAYA LLANIALVSG VASFFLSLSL TAVLYGKMNI
     QAFLFKIALI FFTHASYLFS DMAYQLPYFK KNKRFFLCNT TIHLFGILII IFGMGPFKWN
     VLVSFKFYQN YLFSSVSGIV LYAALFFLII PCVTFATLVK KAFMMKSIAY RQQLLFLAGA
     VALGFITWVI ILFLFAVFPW VFVFFPLGGV FIVLFSQWAF ASTGIVSFKE VVFALSRFVL
     CTVGFSCTAG YISVFWVHRF STLDMQFVFG FFIVYALFAL RDYAFDACSV FFGEIADSGQ
     KLAAELQALD YTAKPAQVLR TFMDTLRMRI ACRGLTFLLA DEAGVFKTVY SDFEEMATHE
     MEHQSLQYFF NQDVLMIRKS DPVIDHARQA IRTDILHFFD ITHAQMIVLI REAQKLIGCL
     CFGMKNNGVE YSNHDQHVLE KLYSHFVLVS YYLQNIAKQD VVITVDKELK MSHQIIESIQ
     RKRDFIQDAS VEVDSIAYSA HQLGGDFVDF IKLSEKRYLL VIGDVSGKGL AASMSMVILK
     SVLSTFLRGL CLEETAVFTT FIEKINRFIK DNLPCGTFFA GVFCILDLAT HTLYYANCGI
     PLMSMYVASY KNVVEIQGEG RVLGFVKDVM PFLRVRKVQL GQGDVVVFST DGMVEVQNLQ
     RERFGNERVD RILQESHGLP VSQITRTIYA RLCEFMARDM QDDVTVLAIK CLGPR
//