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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-228-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:TP_0216
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000000811 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Chaperone protein DnaKPRO_0000078577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei197 – 1971Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO83246.

Expressioni

Inductioni

By stress conditions e.g. heat shock (By similarity).By similarity

Interactioni

Protein-protein interaction databases

IntActiO83246. 2 interactions.
STRINGi243276.TP0216.

Structurei

3D structure databases

ProteinModelPortaliO83246.
SMRiO83246. Positions 1-594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
KOiK04043.
OMAiFYSAKRF.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIIGIDLG TTNSCVAIME GGEPVVIQNA EGGRTTPSII GFTSDGGRVV
60 70 80 90 100
GQPAKNQMVT NPEHTIYSIK RFIGSRFNEL TGEAKKVPYK IVPQGDDVRV
110 120 130 140 150
EVEGKLYSTQ EISAFILQKM KKTAEDYLGE AVTEAVITVP AYFNDAQRQA
160 170 180 190 200
TKDAGKIAGL DVKRIINEPT AASLAFGFNK DSKREKIIAV YDLGGGTFDI
210 220 230 240 250
SILELGDGVF EVKSTNGDTH LGGDDFDARI VQWLEQGFKS DTGIDLGNDR
260 270 280 290 300
MALQRLREAA EKAKIALSSS ASTEINLPFI TADANGPKHL QRTLSRSEFE
310 320 330 340 350
KMTDDLFERT KEPCRKALKD AGISADRIDE ILLVGGSTRM PKVAHVIKDV
360 370 380 390 400
FGKEGSKGVN PDEAVAIGAA IQGGILGGDV KDVLLLDVTP LSLGIETMGG
410 420 430 440 450
VFTPLISRNT TIPTRKSQVF STAADGQTAV SIHVLQGERG MANQNRTLGN
460 470 480 490 500
FDLVGIPPAP RGVPQIEVTF DIDANGIVHV SAKDLGTGKE QHIRIESSSG
510 520 530 540 550
LSESEIDRMV KEAEANAESD KREREKIEAR NVADSLIYQT EKTLKEAGDG
560 570 580 590 600
VNAADRARID EAIAELKTVL SGDDVASIKA KTEILQQASY KIAEEMYKRQ
610 620 630
AAAGAAAGKK SDAPSGNEAE GGDVDYEVVK DEDSK
Length:635
Mass (Da):68,042
Last modified:November 1, 1998 - v1
Checksum:i11244A863A4504CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65204.1.
PIRiF71352.
RefSeqiWP_010881664.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65204; AAC65204; TP_0216.
GeneIDi2611514.
KEGGitpa:TP_0216.
PATRICi20530405. VBITrePal57110_0233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65204.1.
PIRiF71352.
RefSeqiWP_010881664.1. NC_021490.2.

3D structure databases

ProteinModelPortaliO83246.
SMRiO83246. Positions 1-594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO83246. 2 interactions.
STRINGi243276.TP0216.

Proteomic databases

PRIDEiO83246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC65204; AAC65204; TP_0216.
GeneIDi2611514.
KEGGitpa:TP_0216.
PATRICi20530405. VBITrePal57110_0233.

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
KOiK04043.
OMAiFYSAKRF.

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-228-MONOMER.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_TREPA
AccessioniPrimary (citable) accession number: O83246
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.