SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O83159

- PCKG_TREPA

UniProt

O83159 - PCKG_TREPA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, pckA, TP_0122
Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711Substrate By similarity
Binding sitei215 – 2151Substrate; via amide nitrogen By similarity
Metal bindingi222 – 2221Manganese By similarity
Binding sitei222 – 2221Substrate By similarity
Metal bindingi242 – 2421Manganese; via tele nitrogen By similarity
Binding sitei264 – 2641Substrate By similarity
Active sitei266 – 2661 By similarity
Metal bindingi289 – 2891Manganese By similarity
Binding sitei387 – 3871GTP By similarity
Binding sitei418 – 4181GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi265 – 2706GTP By similarity
Nucleotide bindingi514 – 5174GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-130-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Synonyms:pckA
Ordered Locus Names:TP_0122
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation
PRO_0000103616Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243276.TP0122.

Structurei

3D structure databases

ProteinModelPortaliO83159.
SMRiO83159. Positions 9-606.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni385 – 3873Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
KOiK01596.
OMAiWDNPAGV.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83159-1 [UniParc]FASTAAdd to Basket

« Hide

MELHEIAHAR AKAWIEEMVA LCAPDTVYVC DGSKKEYDTI MQKMVDAGLA    50
TPLKKRKNCF LFRSQPSDVA RVEARTFIAS KREDDAGPTN HWTDPAELKK 100
TMTGLYSQCM KGRTMYVIPF SMGPVGSPIS KNGIEITDSE YVVCNMHIMT 150
RVGTRVLEAL GTDGEFVPCL HSVGKPLGPG VTDAGQWPCA DMERKYISHF 200
PEERLVWSFG SGYGGNALLG KKCFALRIAS VLARDEGWLA EHMLILKITN 250
PAGKTKYIGA AFPSACGKTN LAMMIPTLPG WKVETVGDDI AWMKFGKDGR 300
LYAINPEAGF FGVAPGTSDF SNKNAMDSIK ENAIFTNCGL TEDGDVWWEG 350
IGYPAKGTII DWHGVSRPAP TRDKSPKGEE IAHPNARFTA PARQCPAIAS 400
NWEDPEGVPI DAFLFGGRRP STVPLVHQAR DWNHGVFLGS IIGSEVTAAV 450
ISDQVGQIRR DPFAMLPFCG YHMADYFSHW IKLGSQARAE NLPKIFCVNW 500
FRKDAEGNFL WPGYGDNSRV LAWIFDRCDG VDNAVETAIG WMPKEGALNT 550
EGLNVSTQAV KELLSVDIAG WKKEIKDIRE NHYPKFGARL PQQLRDALEV 600
LEARINGSEG AACTRDMC 618
Length:618
Mass (Da):68,125
Last modified:November 1, 1998 - v1
Checksum:i4230B8F77DDD4AA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65112.1.
PIRiA71364.
RefSeqiNP_218562.1. NC_000919.1.
YP_008090996.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65112; AAC65112; TP_0122.
GeneIDi15851418.
2610930.
KEGGitpa:TP0122.
tpw:TPANIC_0122.
PATRICi20530199. VBITrePal57110_0133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65112.1 .
PIRi A71364.
RefSeqi NP_218562.1. NC_000919.1.
YP_008090996.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83159.
SMRi O83159. Positions 9-606.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243276.TP0122.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65112 ; AAC65112 ; TP_0122 .
GeneIDi 15851418.
2610930.
KEGGi tpa:TP0122.
tpw:TPANIC_0122.
PATRICi 20530199. VBITrePal57110_0133.

Phylogenomic databases

eggNOGi COG1274.
KOi K01596.
OMAi WDNPAGV.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci TPAL243276:GC1H-130-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiPCKG_TREPA
AccessioniPrimary (citable) accession number: O83159
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi