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O83110

- CLPB_TREPA

UniProt

O83110 - CLPB_TREPA

Protein

Chaperone protein ClpB

Gene

clpB

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi206 – 2138ATP 1By similarity
    Nucleotide bindingi609 – 6168ATP 2By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. protein processing Source: InterPro
    2. response to heat Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTPAL243276:GC1H-76-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chaperone protein ClpB
    Gene namesi
    Name:clpB
    Ordered Locus Names:TP_0071
    OrganismiTreponema pallidum (strain Nichols)
    Taxonomic identifieri243276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000000811: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 878878Chaperone protein ClpBPRO_0000191197Add
    BLAST

    Proteomic databases

    PRIDEiO83110.

    Interactioni

    Subunit structurei

    Homohexamer. The oligomerization is ATP-dependent By similarity.By similarity

    Protein-protein interaction databases

    IntActiO83110. 5 interactions.
    STRINGi243276.TP0071.

    Structurei

    3D structure databases

    ProteinModelPortaliO83110.
    SMRiO83110. Positions 159-351.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 143143N-terminalBy similarityAdd
    BLAST
    Regioni159 – 340182NBD1By similarityAdd
    BLAST
    Regioni341 – 549209LinkerBy similarityAdd
    BLAST
    Regioni559 – 783225NBD2By similarityAdd
    BLAST
    Regioni784 – 87895C-terminalBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili391 – 525135By similarityAdd
    BLAST

    Domaini

    The N-terminal domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer By similarity.By similarity

    Sequence similaritiesi

    Belongs to the ClpA/ClpB family.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0542.
    KOiK03695.
    OMAiMEEAVTP.
    OrthoDBiEOG65F8SM.

    Family and domain databases

    Gene3Di1.10.1780.10. 1 hit.
    3.40.50.300. 3 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR017730. Chaperonin_ClpB.
    IPR019489. Clp_ATPase_C.
    IPR004176. Clp_N.
    IPR001270. ClpA/B.
    IPR018368. ClpA/B_CS1.
    IPR028299. ClpA/B_CS2.
    IPR023150. Dbl_Clp-N.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    PF07724. AAA_2. 1 hit.
    PF02861. Clp_N. 2 hits.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view]
    PRINTSiPR00300. CLPPROTEASEA.
    SMARTiSM00382. AAA. 2 hits.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    TIGRFAMsiTIGR03346. chaperone_ClpB. 1 hit.
    PROSITEiPS00870. CLPAB_1. 1 hit.
    PS00871. CLPAB_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O83110-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTDRYTVKA SEALNDAISL AEAENHGQVE EEHLLHALLS QKDGIISPLI    50
    EKIGAKPDFL YDELLQCLRR KPRVTGPAAQ TRCAPTLSKA CARAERLALK 100
    NQDEYVSCEH LLLAISETDS NTARLLHSQG ITSKTISAAL KDIRGSKRVT 150
    SQDPESTFQC LEKYCRDLTT LAREEKIDPV IGRDEEIRRV MQVLSRRTKN 200
    NPVLIGEPGV GKTAIVEGLA RRIVSGDVPE SLKGKRLLSL DLGALVAGAK 250
    FRGEFEERLK AVIEAVQKSD GGVILFIDEL HTLVGAGASE GSMDASNLLK 300
    PALARGELRS IGATTLNEYR KYIEKDAALE RRFQQVYCVQ PTVEDTIAIL 350
    RGLQEKYEVH HGVRIKDEAL VAATVLSDRY ITNRFLPDKA IDLVDEAASR 400
    LKMEIESQPV ELDQVERKIL QLNIEKASLL KESDPASKER LEKLEKELAG 450
    FLERRAAMQV QWQNEKGRIE ESRRYKEELE RLRIEETMFS REGDLNKAAE 500
    LRYGKIPELE KKIMLLTAEV EKKSGLEGQL LREEVCEEDI AKIISMWTGI 550
    PVSKMMASEQ QKYLQLESVL MQRVVGQDEA VRVISDAIRR NKAGLSDTRR 600
    PLGSFLCVGP TGVGKTELAR TLADFLFNDE RALTRIDMSE YMEKHAISRL 650
    IGAPPGYVGY DEGGQLTEAV RRRPYSVLLF DEVEKAHQDV FNIFLQILDD 700
    GRLTDGQGRV VDFRNTIIIM TSNIGSEHIL SARESRTHTS DLPVPETQST 750
    EEQTLPEQIR GLLHTYFRPE FLNRIDEVLI FKRLTRKHIR LITDIQLQMV 800
    VERLESRHIK LRVRDAAKAY LAERGYDDTF GARPLKRAIQ TELENALARE 850
    ILSGRFRGGS TIVVDMCKDA LCFTEQTS 878
    Length:878
    Mass (Da):98,981
    Last modified:November 1, 1998 - v1
    Checksum:i7D9E7419E42A2202
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65062.1.
    PIRiG71371.
    RefSeqiNP_218511.1. NC_000919.1.
    YP_008090945.1. NC_021490.2.

    Genome annotation databases

    EnsemblBacteriaiAAC65062; AAC65062; TP_0071.
    GeneIDi15851364.
    2611222.
    KEGGitpa:TP0071.
    tpw:TPANIC_0071.
    PATRICi20530079. VBITrePal57110_0076.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65062.1 .
    PIRi G71371.
    RefSeqi NP_218511.1. NC_000919.1.
    YP_008090945.1. NC_021490.2.

    3D structure databases

    ProteinModelPortali O83110.
    SMRi O83110. Positions 159-351.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O83110. 5 interactions.
    STRINGi 243276.TP0071.

    Proteomic databases

    PRIDEi O83110.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC65062 ; AAC65062 ; TP_0071 .
    GeneIDi 15851364.
    2611222.
    KEGGi tpa:TP0071.
    tpw:TPANIC_0071.
    PATRICi 20530079. VBITrePal57110_0076.

    Phylogenomic databases

    eggNOGi COG0542.
    KOi K03695.
    OMAi MEEAVTP.
    OrthoDBi EOG65F8SM.

    Enzyme and pathway databases

    BioCyci TPAL243276:GC1H-76-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1780.10. 1 hit.
    3.40.50.300. 3 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR017730. Chaperonin_ClpB.
    IPR019489. Clp_ATPase_C.
    IPR004176. Clp_N.
    IPR001270. ClpA/B.
    IPR018368. ClpA/B_CS1.
    IPR028299. ClpA/B_CS2.
    IPR023150. Dbl_Clp-N.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    PF07724. AAA_2. 1 hit.
    PF02861. Clp_N. 2 hits.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view ]
    PRINTSi PR00300. CLPPROTEASEA.
    SMARTi SM00382. AAA. 2 hits.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    TIGRFAMsi TIGR03346. chaperone_ClpB. 1 hit.
    PROSITEi PS00870. CLPAB_1. 1 hit.
    PS00871. CLPAB_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nichols.

    Entry informationi

    Entry nameiCLPB_TREPA
    AccessioniPrimary (citable) accession number: O83110
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3