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O83110

- CLPB_TREPA

UniProt

O83110 - CLPB_TREPA

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Protein

Chaperone protein ClpB

Gene
clpB, TP_0071
Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi206 – 2138ATP 1 By similarity
Nucleotide bindingi609 – 6168ATP 2 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro

GO - Biological processi

  1. protein processing Source: InterPro
  2. response to heat Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-76-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein ClpB
Gene namesi
Name:clpB
Ordered Locus Names:TP_0071
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Chaperone protein ClpBPRO_0000191197Add
BLAST

Proteomic databases

PRIDEiO83110.

Interactioni

Subunit structurei

Homohexamer. The oligomerization is ATP-dependent By similarity.

Protein-protein interaction databases

IntActiO83110. 5 interactions.
STRINGi243276.TP0071.

Structurei

3D structure databases

ProteinModelPortaliO83110.
SMRiO83110. Positions 159-351.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 143143N-terminal By similarityAdd
BLAST
Regioni159 – 340182NBD1 By similarityAdd
BLAST
Regioni341 – 549209Linker By similarityAdd
BLAST
Regioni559 – 783225NBD2 By similarityAdd
BLAST
Regioni784 – 87895C-terminal By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili391 – 525135 By similarityAdd
BLAST

Domaini

The N-terminal domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer By similarity.

Sequence similaritiesi

Belongs to the ClpA/ClpB family.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0542.
KOiK03695.
OMAiMEEAVTP.
OrthoDBiEOG65F8SM.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR017730. Chaperonin_ClpB.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR023150. Dbl_Clp-N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03346. chaperone_ClpB. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83110-1 [UniParc]FASTAAdd to Basket

« Hide

MNTDRYTVKA SEALNDAISL AEAENHGQVE EEHLLHALLS QKDGIISPLI    50
EKIGAKPDFL YDELLQCLRR KPRVTGPAAQ TRCAPTLSKA CARAERLALK 100
NQDEYVSCEH LLLAISETDS NTARLLHSQG ITSKTISAAL KDIRGSKRVT 150
SQDPESTFQC LEKYCRDLTT LAREEKIDPV IGRDEEIRRV MQVLSRRTKN 200
NPVLIGEPGV GKTAIVEGLA RRIVSGDVPE SLKGKRLLSL DLGALVAGAK 250
FRGEFEERLK AVIEAVQKSD GGVILFIDEL HTLVGAGASE GSMDASNLLK 300
PALARGELRS IGATTLNEYR KYIEKDAALE RRFQQVYCVQ PTVEDTIAIL 350
RGLQEKYEVH HGVRIKDEAL VAATVLSDRY ITNRFLPDKA IDLVDEAASR 400
LKMEIESQPV ELDQVERKIL QLNIEKASLL KESDPASKER LEKLEKELAG 450
FLERRAAMQV QWQNEKGRIE ESRRYKEELE RLRIEETMFS REGDLNKAAE 500
LRYGKIPELE KKIMLLTAEV EKKSGLEGQL LREEVCEEDI AKIISMWTGI 550
PVSKMMASEQ QKYLQLESVL MQRVVGQDEA VRVISDAIRR NKAGLSDTRR 600
PLGSFLCVGP TGVGKTELAR TLADFLFNDE RALTRIDMSE YMEKHAISRL 650
IGAPPGYVGY DEGGQLTEAV RRRPYSVLLF DEVEKAHQDV FNIFLQILDD 700
GRLTDGQGRV VDFRNTIIIM TSNIGSEHIL SARESRTHTS DLPVPETQST 750
EEQTLPEQIR GLLHTYFRPE FLNRIDEVLI FKRLTRKHIR LITDIQLQMV 800
VERLESRHIK LRVRDAAKAY LAERGYDDTF GARPLKRAIQ TELENALARE 850
ILSGRFRGGS TIVVDMCKDA LCFTEQTS 878
Length:878
Mass (Da):98,981
Last modified:November 1, 1998 - v1
Checksum:i7D9E7419E42A2202
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65062.1.
PIRiG71371.
RefSeqiNP_218511.1. NC_000919.1.
YP_008090945.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65062; AAC65062; TP_0071.
GeneIDi15851364.
2611222.
KEGGitpa:TP0071.
tpw:TPANIC_0071.
PATRICi20530079. VBITrePal57110_0076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65062.1 .
PIRi G71371.
RefSeqi NP_218511.1. NC_000919.1.
YP_008090945.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83110.
SMRi O83110. Positions 159-351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O83110. 5 interactions.
STRINGi 243276.TP0071.

Proteomic databases

PRIDEi O83110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65062 ; AAC65062 ; TP_0071 .
GeneIDi 15851364.
2611222.
KEGGi tpa:TP0071.
tpw:TPANIC_0071.
PATRICi 20530079. VBITrePal57110_0076.

Phylogenomic databases

eggNOGi COG0542.
KOi K03695.
OMAi MEEAVTP.
OrthoDBi EOG65F8SM.

Enzyme and pathway databases

BioCyci TPAL243276:GC1H-76-MONOMER.

Family and domain databases

Gene3Di 1.10.1780.10. 1 hit.
3.40.50.300. 3 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR017730. Chaperonin_ClpB.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR023150. Dbl_Clp-N.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view ]
PRINTSi PR00300. CLPPROTEASEA.
SMARTi SM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
TIGRFAMsi TIGR03346. chaperone_ClpB. 1 hit.
PROSITEi PS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiCLPB_TREPA
AccessioniPrimary (citable) accession number: O83110
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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