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O83110

- CLPB_TREPA

UniProt

O83110 - CLPB_TREPA

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Protein

Chaperone protein ClpB

Gene

clpB

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi206 – 2138ATP 1By similarity
Nucleotide bindingi609 – 6168ATP 2By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein processing Source: InterPro
  2. response to heat Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-76-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein ClpB
Gene namesi
Name:clpB
Ordered Locus Names:TP_0071
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Chaperone protein ClpBPRO_0000191197Add
BLAST

Proteomic databases

PRIDEiO83110.

Interactioni

Subunit structurei

Homohexamer. The oligomerization is ATP-dependent (By similarity).By similarity

Protein-protein interaction databases

IntActiO83110. 5 interactions.
STRINGi243276.TP0071.

Structurei

3D structure databases

ProteinModelPortaliO83110.
SMRiO83110. Positions 159-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 143143N-terminalBy similarityAdd
BLAST
Regioni159 – 340182NBD1By similarityAdd
BLAST
Regioni341 – 549209LinkerBy similarityAdd
BLAST
Regioni559 – 783225NBD2By similarityAdd
BLAST
Regioni784 – 87895C-terminalBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili391 – 525135By similarityAdd
BLAST

Domaini

The N-terminal domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer (By similarity).By similarity

Sequence similaritiesi

Belongs to the ClpA/ClpB family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0542.
KOiK03695.
OMAiMEEAVTP.
OrthoDBiEOG65F8SM.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR017730. Chaperonin_ClpB.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR023150. Dbl_Clp-N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03346. chaperone_ClpB. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83110-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTDRYTVKA SEALNDAISL AEAENHGQVE EEHLLHALLS QKDGIISPLI
60 70 80 90 100
EKIGAKPDFL YDELLQCLRR KPRVTGPAAQ TRCAPTLSKA CARAERLALK
110 120 130 140 150
NQDEYVSCEH LLLAISETDS NTARLLHSQG ITSKTISAAL KDIRGSKRVT
160 170 180 190 200
SQDPESTFQC LEKYCRDLTT LAREEKIDPV IGRDEEIRRV MQVLSRRTKN
210 220 230 240 250
NPVLIGEPGV GKTAIVEGLA RRIVSGDVPE SLKGKRLLSL DLGALVAGAK
260 270 280 290 300
FRGEFEERLK AVIEAVQKSD GGVILFIDEL HTLVGAGASE GSMDASNLLK
310 320 330 340 350
PALARGELRS IGATTLNEYR KYIEKDAALE RRFQQVYCVQ PTVEDTIAIL
360 370 380 390 400
RGLQEKYEVH HGVRIKDEAL VAATVLSDRY ITNRFLPDKA IDLVDEAASR
410 420 430 440 450
LKMEIESQPV ELDQVERKIL QLNIEKASLL KESDPASKER LEKLEKELAG
460 470 480 490 500
FLERRAAMQV QWQNEKGRIE ESRRYKEELE RLRIEETMFS REGDLNKAAE
510 520 530 540 550
LRYGKIPELE KKIMLLTAEV EKKSGLEGQL LREEVCEEDI AKIISMWTGI
560 570 580 590 600
PVSKMMASEQ QKYLQLESVL MQRVVGQDEA VRVISDAIRR NKAGLSDTRR
610 620 630 640 650
PLGSFLCVGP TGVGKTELAR TLADFLFNDE RALTRIDMSE YMEKHAISRL
660 670 680 690 700
IGAPPGYVGY DEGGQLTEAV RRRPYSVLLF DEVEKAHQDV FNIFLQILDD
710 720 730 740 750
GRLTDGQGRV VDFRNTIIIM TSNIGSEHIL SARESRTHTS DLPVPETQST
760 770 780 790 800
EEQTLPEQIR GLLHTYFRPE FLNRIDEVLI FKRLTRKHIR LITDIQLQMV
810 820 830 840 850
VERLESRHIK LRVRDAAKAY LAERGYDDTF GARPLKRAIQ TELENALARE
860 870
ILSGRFRGGS TIVVDMCKDA LCFTEQTS
Length:878
Mass (Da):98,981
Last modified:November 1, 1998 - v1
Checksum:i7D9E7419E42A2202
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65062.1.
PIRiG71371.
RefSeqiNP_218511.1. NC_000919.1.
YP_008090945.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65062; AAC65062; TP_0071.
GeneIDi15851364.
2611222.
KEGGitpa:TP0071.
tpw:TPANIC_0071.
PATRICi20530079. VBITrePal57110_0076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000520 Genomic DNA. Translation: AAC65062.1 .
PIRi G71371.
RefSeqi NP_218511.1. NC_000919.1.
YP_008090945.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83110.
SMRi O83110. Positions 159-351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O83110. 5 interactions.
STRINGi 243276.TP0071.

Proteomic databases

PRIDEi O83110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65062 ; AAC65062 ; TP_0071 .
GeneIDi 15851364.
2611222.
KEGGi tpa:TP0071.
tpw:TPANIC_0071.
PATRICi 20530079. VBITrePal57110_0076.

Phylogenomic databases

eggNOGi COG0542.
KOi K03695.
OMAi MEEAVTP.
OrthoDBi EOG65F8SM.

Enzyme and pathway databases

BioCyci TPAL243276:GC1H-76-MONOMER.

Family and domain databases

Gene3Di 1.10.1780.10. 1 hit.
3.40.50.300. 3 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR017730. Chaperonin_ClpB.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR023150. Dbl_Clp-N.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view ]
PRINTSi PR00300. CLPPROTEASEA.
SMARTi SM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
TIGRFAMsi TIGR03346. chaperone_ClpB. 1 hit.
PROSITEi PS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiCLPB_TREPA
AccessioniPrimary (citable) accession number: O83110
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3