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O83092

- RIR2_TREPA

UniProt

O83092 - RIR2_TREPA

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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi94 – 941Iron 1PROSITE-ProRule annotation
Metal bindingi124 – 1241Iron 1PROSITE-ProRule annotation
Metal bindingi124 – 1241Iron 2By similarity
Metal bindingi127 – 1271Iron 1PROSITE-ProRule annotation
Active sitei131 – 1311PROSITE-ProRule annotation
Metal bindingi191 – 1911Iron 2By similarity
Metal bindingi225 – 2251Iron 2By similarity
Metal bindingi228 – 2281Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. deoxyribonucleotide biosynthetic process Source: InterPro
  3. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciTPAL243276:GC1H-58-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:TP_0053
OrganismiTreponema pallidum (strain Nichols)
Taxonomic identifieri243276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000000811: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Ribonucleoside-diphosphate reductase subunit betaPRO_0000190487Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

IntActiO83092. 3 interactions.
MINTiMINT-6480942.
STRINGi243276.TP0053.

Structurei

3D structure databases

ProteinModelPortaliO83092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiCTFACLL.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O83092-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMESSTILQR RALFNEAGDI ELHKRRMVGG NTTNLNDFNN MKYPWVSKWY
60 70 80 90 100
RQAMNNFWIP EEINMSSDVQ DYRNLSAIEK TAYDKILSFL IFLDSIQTAN
110 120 130 140 150
LPNIGQYITA NEINLCLTIQ AFQEAVHSQS YSYMLDTICS PEERNDILYQ
160 170 180 190 200
WKDDEHLLAR NKFIGNLYNE FQDDKSVLAL LKVAIANYVL EGIYFYSGFM
210 220 230 240 250
FFYNLGRNNK MPGSVQEIRY INRDENTHLW LFRSIIQELQ KEEPQVFTAR
260 270 280 290 300
NVRLFRDMIR EGCEQEIKWG DYVIGDQIPG LNRHMVADYI RYLGNLRCEN
310 320 330 340 350
LGFEPLYEGH RVEPESMSWV SQYSNANLIK TDFFEAKSTA YAKSSAMVDD

L
Length:351
Mass (Da):41,199
Last modified:November 1, 1998 - v1
Checksum:i5B373A7FCBBF049A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65049.1.
PIRiG71372.
RefSeqiNP_218493.1. NC_000919.1.
YP_008090928.1. NC_021490.2.

Genome annotation databases

EnsemblBacteriaiAAC65049; AAC65049; TP_0053.
GeneIDi15851347.
2611427.
KEGGitpa:TP0053.
tpw:TPANIC_0053.
PATRICi20530039. VBITrePal57110_0056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000520 Genomic DNA. Translation: AAC65049.1 .
PIRi G71372.
RefSeqi NP_218493.1. NC_000919.1.
YP_008090928.1. NC_021490.2.

3D structure databases

ProteinModelPortali O83092.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O83092. 3 interactions.
MINTi MINT-6480942.
STRINGi 243276.TP0053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC65049 ; AAC65049 ; TP_0053 .
GeneIDi 15851347.
2611427.
KEGGi tpa:TP0053.
tpw:TPANIC_0053.
PATRICi 20530039. VBITrePal57110_0056.

Phylogenomic databases

eggNOGi COG0208.
KOi K00526.
OMAi CTFACLL.
OrthoDBi EOG6J48J7.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci TPAL243276:GC1H-58-MONOMER.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
PIRSFi PIRSF000355. NrdB. 1 hit.
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nichols.

Entry informationi

Entry nameiRIR2_TREPA
AccessioniPrimary (citable) accession number: O83092
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3