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O83092 (RIR2_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase subunit beta

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:nrdB
Ordered Locus Names:TP_0053
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190487

Sites

Active site1311 By similarity
Metal binding941Iron 1 By similarity
Metal binding1241Iron 1 By similarity
Metal binding1241Iron 2 By similarity
Metal binding1271Iron 1 By similarity
Metal binding1911Iron 2 By similarity
Metal binding2251Iron 2 By similarity
Metal binding2281Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
O83092 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 5B373A7FCBBF049A

FASTA35141,199
        10         20         30         40         50         60 
MMESSTILQR RALFNEAGDI ELHKRRMVGG NTTNLNDFNN MKYPWVSKWY RQAMNNFWIP 

        70         80         90        100        110        120 
EEINMSSDVQ DYRNLSAIEK TAYDKILSFL IFLDSIQTAN LPNIGQYITA NEINLCLTIQ 

       130        140        150        160        170        180 
AFQEAVHSQS YSYMLDTICS PEERNDILYQ WKDDEHLLAR NKFIGNLYNE FQDDKSVLAL 

       190        200        210        220        230        240 
LKVAIANYVL EGIYFYSGFM FFYNLGRNNK MPGSVQEIRY INRDENTHLW LFRSIIQELQ 

       250        260        270        280        290        300 
KEEPQVFTAR NVRLFRDMIR EGCEQEIKWG DYVIGDQIPG LNRHMVADYI RYLGNLRCEN 

       310        320        330        340        350 
LGFEPLYEGH RVEPESMSWV SQYSNANLIK TDFFEAKSTA YAKSSAMVDD L 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000520 Genomic DNA. Translation: AAC65049.1.
PIRG71372.
RefSeqNP_218493.1. NC_000919.1.
YP_008090928.1. NC_021490.2.

3D structure databases

ProteinModelPortalO83092.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO83092. 3 interactions.
MINTMINT-6480942.
STRING243276.TP0053.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC65049; AAC65049; TP_0053.
GeneID15851347.
2611427.
KEGGtpa:TP0053.
tpw:TPANIC_0053.
PATRIC20530039. VBITrePal57110_0056.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0208.
KOK00526.
OMACTFACLL.
OrthoDBEOG6J48J7.

Enzyme and pathway databases

BioCycTPAL243276:GC1H-58-MONOMER.
UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFPIRSF000355. NrdB. 1 hit.
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_TREPA
AccessionPrimary (citable) accession number: O83092
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways