Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O83092

- RIR2_TREPA

UniProt

O83092 - RIR2_TREPA

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi94 – 941Iron 1PROSITE-ProRule annotation
    Metal bindingi124 – 1241Iron 1PROSITE-ProRule annotation
    Metal bindingi124 – 1241Iron 2By similarity
    Metal bindingi127 – 1271Iron 1PROSITE-ProRule annotation
    Active sitei131 – 1311PROSITE-ProRule annotation
    Metal bindingi191 – 1911Iron 2By similarity
    Metal bindingi225 – 2251Iron 2By similarity
    Metal bindingi228 – 2281Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. deoxyribonucleotide biosynthetic process Source: InterPro
    3. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciTPAL243276:GC1H-58-MONOMER.
    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:nrdB
    Ordered Locus Names:TP_0053
    OrganismiTreponema pallidum (strain Nichols)
    Taxonomic identifieri243276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000000811: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. ribonucleoside-diphosphate reductase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Ribonucleoside-diphosphate reductase subunit betaPRO_0000190487Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.By similarity

    Protein-protein interaction databases

    IntActiO83092. 3 interactions.
    MINTiMINT-6480942.
    STRINGi243276.TP0053.

    Structurei

    3D structure databases

    ProteinModelPortaliO83092.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    KOiK00526.
    OMAiCTFACLL.
    OrthoDBiEOG6J48J7.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026023. RNR_bsu_prok.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000355. NrdB. 1 hit.
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O83092-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMESSTILQR RALFNEAGDI ELHKRRMVGG NTTNLNDFNN MKYPWVSKWY    50
    RQAMNNFWIP EEINMSSDVQ DYRNLSAIEK TAYDKILSFL IFLDSIQTAN 100
    LPNIGQYITA NEINLCLTIQ AFQEAVHSQS YSYMLDTICS PEERNDILYQ 150
    WKDDEHLLAR NKFIGNLYNE FQDDKSVLAL LKVAIANYVL EGIYFYSGFM 200
    FFYNLGRNNK MPGSVQEIRY INRDENTHLW LFRSIIQELQ KEEPQVFTAR 250
    NVRLFRDMIR EGCEQEIKWG DYVIGDQIPG LNRHMVADYI RYLGNLRCEN 300
    LGFEPLYEGH RVEPESMSWV SQYSNANLIK TDFFEAKSTA YAKSSAMVDD 350
    L 351
    Length:351
    Mass (Da):41,199
    Last modified:November 1, 1998 - v1
    Checksum:i5B373A7FCBBF049A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65049.1.
    PIRiG71372.
    RefSeqiNP_218493.1. NC_000919.1.
    YP_008090928.1. NC_021490.2.

    Genome annotation databases

    EnsemblBacteriaiAAC65049; AAC65049; TP_0053.
    GeneIDi15851347.
    2611427.
    KEGGitpa:TP0053.
    tpw:TPANIC_0053.
    PATRICi20530039. VBITrePal57110_0056.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000520 Genomic DNA. Translation: AAC65049.1 .
    PIRi G71372.
    RefSeqi NP_218493.1. NC_000919.1.
    YP_008090928.1. NC_021490.2.

    3D structure databases

    ProteinModelPortali O83092.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O83092. 3 interactions.
    MINTi MINT-6480942.
    STRINGi 243276.TP0053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC65049 ; AAC65049 ; TP_0053 .
    GeneIDi 15851347.
    2611427.
    KEGGi tpa:TP0053.
    tpw:TPANIC_0053.
    PATRICi 20530039. VBITrePal57110_0056.

    Phylogenomic databases

    eggNOGi COG0208.
    KOi K00526.
    OMAi CTFACLL.
    OrthoDBi EOG6J48J7.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .
    BioCyci TPAL243276:GC1H-58-MONOMER.

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026023. RNR_bsu_prok.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000355. NrdB. 1 hit.
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nichols.

    Entry informationi

    Entry nameiRIR2_TREPA
    AccessioniPrimary (citable) accession number: O83092
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3