ID   LDHD_TREPA              Reviewed;         331 AA.
AC   O83080;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-JUN-2009, entry version 56.
DE   RecName: Full=D-lactate dehydrogenase;
DE            Short=D-LDH;
DE            EC=1.1.1.28;
DE   AltName: Full=D-specific D-2-hydroxyacid dehydrogenase;
GN   Name=ldhD; OrderedLocusNames=TP_0037;
OS   Treponema pallidum.
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
OX   NCBI_TaxID=160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   MEDLINE=98332770; PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M.,
RA   Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D.,
RA   Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M.,
RA   Weidman J.F., Smith H.O., Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis
RT   spirochete.";
RL   Science 281:375-388(1998).
CC   -!- CATALYTIC ACTIVITY: (R)-lactate + NAD(+) = pyruvate + NADH.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family.
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DR   EMBL; AE000520; AAC65033.1; -; Genomic_DNA.
DR   PIR; D71373; D71373.
DR   RefSeq; NP_218477.1; -.
DR   HSSP; P30901; 2DLD.
DR   IntAct; O83080; 1.
DR   GeneID; 2611300; -.
DR   GenomeReviews; AE000520_GR; TP_0037.
DR   KEGG; tpa:TP0037; -.
DR   NMPDR; fig|243276.1.peg.36; -.
DR   TIGR; TP_0037; -.
DR   HOGENOM; O83080; -.
DR   OMA; O83080; HAIAEHT.
DR   BioCyc; TPAL243276:TP_0037-MON; -.
DR   BRENDA; 1.1.1.28; 142600.
DR   GO; GO:0008720; F:D-lactate dehydrogenase activity; IEA:EC.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH.
DR   InterPro; IPR006140; D-isomer_2_OHA_DH_NAD-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    331       D-lactate dehydrogenase.
FT                                /FTId=PRO_0000075971.
FT   ACT_SITE    235    235       By similarity.
FT   ACT_SITE    264    264       By similarity.
FT   ACT_SITE    296    296       Proton donor (By similarity).
SQ   SEQUENCE   331 AA;  36873 MW;  773B01E6E2384E0A CRC64;
     MRCVVFNLRE EEAPYVEKWK QSHPGVVVDT YEEPLTAKNK ELLKGYEGLV VMQFLAMEDE
     VYDYMGACKL KVLSTRTAGF DMYNATLLKK HGIRLTNVPS YSPNAIGEYA LAAALQLTRH
     AREIETFVRK RDFRWQKPIL SKELRCSRVG ILGTGRIGQA AARLFKGVGA QVVGFDPYPN
     DAAKEWLTYV SMDELLSTSD VISLHMPATK DSHHLINAKT IAQMKDGVYL VNTARGAVID
     SQALLDSLDK GKIAGAALDA YEFEGPYIPK DNGNNPITDT VYARLVAHER IIYTPHIAFY
     TETAIENMVF NSLDACTTVL RGEPCAAEIK L
//