Reviewed, UniProtKB/Swiss-Prot O83041 (PIP_PLEBO)

Names and origin

Protein names

Recommended name:
    Probable proline iminopeptidase
      Short name=PIP
    EC=3.4.11.5
Alternative name(s):
    Prolyl aminopeptidase
      Short name=PAP

Gene names

Name:

pip

Organism

Plectonema boryanum

Taxonomic identifier

1184 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Oscillatoriales › Leptolyngbya

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Specifically catalyzes the removal of N-terminal proline residues from peptides By similarity.
Catalytic activity	Release of N-terminal proline from a peptide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S33 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Aminopeptidase Hydrolase Protease
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Probable proline iminopeptidase		PRO_0000080844
Sites
	Active site	110	1	Nucleophile By similarity
	Active site	266	1	By similarity
	Active site	294	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	O83041-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 94EF1D7D62F5841E	FASTA	321	36,475
	10 20 30 40 50 60 MRQLYPAIAP YQSGMLPVSA LHTIYYEQSG NPNGKPVVFL HGGPGGGTIP TYRQYFDPSK 70 80 90 100 110 120 WRIILFDQRG AGKSTPHAEL RENTTWDLVS DIEKLRSHLN IDRWFVFGGS WGSTLSLAYS 130 140 150 160 170 180 QTHPDRCLGL ILRGIFLLRR KEILWFYQDG ASWIFPDAWE HYLEPIPPEE RDDMISAYYR 190 200 210 220 230 240 RLTSKDAEIR STAAKAWSVW EGTTSRLIVD PSLQSKFADD EFADAFARIE CHYFINRGFF 250 260 270 280 290 300 ETDDQLLQNC DRIAHIPTVI VQGRYDVVCP MTSAWALHKA LPESELIVVP DAGHSMMEAG 310 320 ILSALIDATD RFVAQKTNGK I

References

[1]	"Cyanobacterial ferredoxin gene." Matsumura T., Fujita Y., Hase T. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DG5.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB017194 Genomic DNA. Translation: BAA32603.1.
3D structure databases
HSSP	HSSP built from PDB template 1AZW based on UniProtKB P52279.
ModBase	Search...
Protein family/group databases
MEROPS	S33.001.
Enzyme and pathway databases
BRENDA	3.4.11.5. 118612.
Family and domain databases
InterPro	IPR000073. AB_hydrolase_1. IPR005944. Pept_S33. IPR002410. Peptidase_S33. [Graphical view]
Pfam	PF00561. Abhydrolase_1. 1 hit. [Graphical view]
PIRSF	PIRSF006431. Pept_S33. 1 hit.
PRINTS	PR00793. PROAMNOPTASE.
TIGRFAMs	TIGR01249. pro_imino_pep_1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PIP_PLEBO

Accession

Primary (citable) accession number: O83041

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)