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Protein

Probable proline iminopeptidase

Gene

pip

Organism
Leptolyngbya boryana (Plectonema boryanum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically catalyzes the removal of N-terminal proline residues from peptides.By similarity

Catalytic activityi

Release of N-terminal proline from a peptide.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei110 – 1101NucleophileBy similarity
Active sitei266 – 2661By similarity
Active sitei294 – 2941Proton donorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERiplebo-pip. Proline_iminopeptidase.
MEROPSiS33.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proline iminopeptidase (EC:3.4.11.5)
Short name:
PIP
Alternative name(s):
Prolyl aminopeptidase
Short name:
PAP
Gene namesi
Name:pip
OrganismiLeptolyngbya boryana (Plectonema boryanum)
Taxonomic identifieri1184 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesLeptolyngbya

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Probable proline iminopeptidasePRO_0000080844Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO83041.
SMRiO83041. Positions 1-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.Curated

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR002410. Peptidase_S33.
IPR005944. Pro_iminopeptidase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006431. Pept_S33. 1 hit.
PRINTSiPR00793. PROAMNOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01249. pro_imino_pep_1. 1 hit.

Sequencei

Sequence statusi: Complete.

O83041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQLYPAIAP YQSGMLPVSA LHTIYYEQSG NPNGKPVVFL HGGPGGGTIP
60 70 80 90 100
TYRQYFDPSK WRIILFDQRG AGKSTPHAEL RENTTWDLVS DIEKLRSHLN
110 120 130 140 150
IDRWFVFGGS WGSTLSLAYS QTHPDRCLGL ILRGIFLLRR KEILWFYQDG
160 170 180 190 200
ASWIFPDAWE HYLEPIPPEE RDDMISAYYR RLTSKDAEIR STAAKAWSVW
210 220 230 240 250
EGTTSRLIVD PSLQSKFADD EFADAFARIE CHYFINRGFF ETDDQLLQNC
260 270 280 290 300
DRIAHIPTVI VQGRYDVVCP MTSAWALHKA LPESELIVVP DAGHSMMEAG
310 320
ILSALIDATD RFVAQKTNGK I
Length:321
Mass (Da):36,475
Last modified:November 1, 1998 - v1
Checksum:i94EF1D7D62F5841E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017194 Genomic DNA. Translation: BAA32603.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017194 Genomic DNA. Translation: BAA32603.1.

3D structure databases

ProteinModelPortaliO83041.
SMRiO83041. Positions 1-312.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiplebo-pip. Proline_iminopeptidase.
MEROPSiS33.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR002410. Peptidase_S33.
IPR005944. Pro_iminopeptidase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006431. Pept_S33. 1 hit.
PRINTSiPR00793. PROAMNOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01249. pro_imino_pep_1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPIP_LEPBY
AccessioniPrimary (citable) accession number: O83041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: October 14, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.