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Protein

Xylose isomerase

Gene

xylA

Organism
Tetragenococcus halophilus (Pediococcus halophilus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991By similarity
Active sitei102 – 1021By similarity
Metal bindingi230 – 2301Magnesium 1By similarity
Metal bindingi266 – 2661Magnesium 1By similarity
Metal bindingi266 – 2661Magnesium 2By similarity
Metal bindingi269 – 2691Magnesium 2By similarity
Metal bindingi294 – 2941Magnesium 1By similarity
Metal bindingi305 – 3051Magnesium 2By similarity
Metal bindingi307 – 3071Magnesium 2By similarity
Metal bindingi337 – 3371Magnesium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiTetragenococcus halophilus (Pediococcus halophilus)
Taxonomic identifieri51669 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeTetragenococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Xylose isomerasePRO_0000195810Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO82845.
SMRiO82845. Positions 3-435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O82845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYFENVPKV QYEGKNAKSK YAFRHYNPEE IIMGKPMKDH LRFSVAFWHT
60 70 80 90 100
MTEDGSDPFG DGTYQRNWEG STPMETAKNR VDAFFEILEK LGAEYFCFHD
110 120 130 140 150
VDIAPQGDSL KEFLENIDVM TDYIKGKMDK TGVKLLWNTA NMFTHPTFVN
160 170 180 190 200
GAATTNNADV YSMAAAQVKK GLDVSKKLNG ENYVFWGGRE GYENLLNTDM
210 220 230 240 250
NFELDNLARF YQMVIDYAQK IDYHPQFLIE PKPKEPTKHQ YDYDAATAMA
260 270 280 290 300
FIQKYNLEDS FKLNLEANHA TLAGHTFEHE LNVAKNYNAL GSLDANQGDL
310 320 330 340 350
LLGWDTDEFP TDIYTATLAM YEVLDFGGIA PGGLNFDAKV RRTSFAMDDL
360 370 380 390 400
ILAHIAGMDT YARGLRAAAK MKDDNFFEQI IANRYESFSS GIGKQIVENK
410 420 430
EDLESLTNYA LSLNGVENKS GHIEHLKSLL NDYLV
Length:435
Mass (Da):49,411
Last modified:November 1, 1998 - v1
Checksum:i4DE49A1C30D265B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009593 Genomic DNA. Translation: BAA31871.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009593 Genomic DNA. Translation: BAA31871.1.

3D structure databases

ProteinModelPortaliO82845.
SMRiO82845. Positions 3-435.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequencing and characterization of the xyl operon of a Gram-positive bacterium, Tetragenococcus halophila."
    Takeda Y., Takase K., Yamato I., Abe K.
    Appl. Environ. Microbiol. 64:2513-2519(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: I-13.

Entry informationi

Entry nameiXYLA_TETHA
AccessioniPrimary (citable) accession number: O82845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: October 14, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.