ID   ARR4_ARATH              Reviewed;         259 AA.
AC   O82798;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-JUN-2009, entry version 64.
DE   RecName: Full=Two-component response regulator ARR4;
DE   AltName: Full=Response regulator 1;
GN   Name=ARR4; Synonyms=ATRR1, IBC7; OrderedLocusNames=At1g10470;
GN   ORFNames=T10O24.8;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   STRAIN=cv. Columbia;
RX   MEDLINE=98151576; PubMed=9482949; DOI=10.1073/pnas.95.5.2691;
RA   Imamura A., Hanaki N., Umeda H., Nakamura A., Suzuki T., Ueguchi C.,
RA   Mizuno T.;
RT   "Response regulators implicated in His-to-Asp phosphotransfer
RT   signaling in Arabidopsis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:2691-2696(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=cv. Columbia;
RX   MEDLINE=98268322; PubMed=9607306; DOI=10.1016/S0014-5793(98)00418-9;
RA   Urao T., Yakubov B., Yamaguchi-Shinozaki K., Shinozaki K.;
RT   "Stress-responsive expression of genes for two-component response
RT   regulator-like proteins in Arabidopsis thaliana.";
RL   FEBS Lett. 427:175-178(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=cv. Wassilewskija;
RX   MEDLINE=98299841; PubMed=9634588; DOI=10.1105/tpc.10.6.1009;
RA   Brandstatter I., Kieber J.J.;
RT   "Two genes with similarity to bacterial response regulators are
RT   rapidly and specifically induced by cytokinin in Arabidopsis.";
RL   Plant Cell 10:1009-1019(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=21016719; PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
RA   White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
RA   Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
RA   Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
RA   Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
RA   Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
RA   Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
RA   Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
RA   Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
RA   Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
RA   Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
RA   Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
RA   Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
RA   Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
RA   Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:816-820(2000).
RN   [5]
RP   INDUCTION.
RX   MEDLINE=98324805; PubMed=9662428; DOI=10.1016/S0014-5793(98)00611-5;
RA   Taniguchi M., Kiba T., Sakakibara H., Ueguchi C., Mizuno T.,
RA   Sugiyama T.;
RT   "Expression of Arabidopsis response regulator homologs is induced by
RT   cytokinins and nitrate.";
RL   FEBS Lett. 429:259-262(1998).
RN   [6]
RP   INDUCTION.
RX   MEDLINE=20567819; PubMed=11115887; DOI=10.1104/pp.124.4.1706;
RA   D'Agostino I.B., Deruere J., Kieber J.J.;
RT   "Characterization of the response of the Arabidopsis response
RT   regulator gene family to cytokinin.";
RL   Plant Physiol. 124:1706-1717(2000).
RN   [7]
RP   FUNCTION, AND INTERACTION WITH PHYTOCHROME B.
RX   MEDLINE=21550767; PubMed=11691995; DOI=10.1126/science.1065022;
RA   Sweere U., Eichenberg K., Lohrmann J., Mira-Rodado V., Baeurle I.,
RA   Kudla J., Nagy F., Schaefer E., Harter K.;
RT   "Interaction of the response regulator ARR4 with phytochrome B in
RT   modulating red light signaling.";
RL   Science 294:1108-1111(2001).
RN   [8]
RP   FUNCTION.
RX   PubMed=14973166; DOI=10.1105/tpc.018978;
RA   To J.P.C., Haberer G., Ferreira F.J., Deruere J., Mason M.G.,
RA   Schaller G.E., Alonso J.M., Ecker J.R., Kieber J.J.;
RT   "Type-A Arabidopsis response regulators are partially redundant
RT   negative regulators of cytokinin signaling.";
RL   Plant Cell 16:658-671(2004).
CC   -!- FUNCTION: Functions as response regulator involved in His-to-Asp
CC       phosphorelay signal transduction system. Phosphorylation of the
CC       Asp residue in the receiver domain activates the ability of the
CC       protein to promote the transcription of target genes. Type-A
CC       response regulators seem to act as negative regulators of the
CC       cytokinin signaling. Modulates red light signaling through its
CC       interaction with the phytochrome B photoreceptor.
CC   -!- SUBUNIT: Interacts with the phytochrome B photoreceptor.
CC   -!- INTERACTION:
CC       O80837:DBP; NbExp=3; IntAct=EBI-625213, EBI-1788073;
CC       P14713:PHYB; NbExp=2; IntAct=EBI-625213, EBI-300727;
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in roots, and stems of
CC       young inflorescences.
CC   -!- INDUCTION: By low temperature, dehydration, abscisic acid (ABA),
CC       cytokinins (BA and zeatin), nitrate and high salinity.
CC   -!- PTM: Two-component system major event consists of a His-to-Asp
CC       phosphorelay between a sensor histidine kinase (HK) and a response
CC       regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC       additionnal intermediate named Histidine-containing
CC       phosphotransfer protein (HPt). This multistep phosphorelay
CC       consists of a His-Asp-His-Asp sequential transfer of a phosphate
CC       group between first an His and an Asp of the HK protein, followed
CC       by the transfer to a conserved His of the HPt protein and finally
CC       the transfer to an Asp in the receiver domain of the RR protein.
CC   -!- SIMILARITY: Belongs to the ARR family. Type-A subfamily.
CC   -!- SIMILARITY: Contains 1 response regulatory domain.
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DR   EMBL; AB008487; BAA34726.1; -; mRNA.
DR   EMBL; AB010915; BAA31143.1; -; mRNA.
DR   EMBL; AF057282; AAC26636.1; -; mRNA.
DR   EMBL; AC007067; AAD39568.1; -; Genomic_DNA.
DR   IPI; IPI00523637; -.
DR   PIR; T48851; T48851.
DR   RefSeq; NP_172517.1; -.
DR   UniGene; At.22981; -.
DR   UniGene; At.67259; -.
DR   IntAct; O82798; 7.
DR   GeneID; 837587; -.
DR   GenomeReviews; CT485782_GR; AT1G10470.
DR   KEGG; ath:AT1G10470; -.
DR   GeneFarm; 4121; 418.
DR   TAIR; At1g10470; -.
DR   OMA; O82798; TISPESS.
DR   ArrayExpress; O82798; -.
DR   GermOnline; AT1G10470; Arabidopsis thaliana.
DR   GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0000156; F:two-component response regulator activity; IEA:InterPro.
DR   GO; GO:0007623; P:circadian rhythm; IMP:TAIR.
DR   GO; GO:0009736; P:cytokinin mediated signaling; IMP:TAIR.
DR   GO; GO:0009793; P:embryonic development ending in seed dormancy; IMP:TAIR.
DR   GO; GO:0010017; P:red or far red light signaling pathway; IMP:TAIR.
DR   GO; GO:0042752; P:regulation of circadian rhythm; IGI:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0010114; P:response to red light; IMP:TAIR.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:two-component signal transduction system (p...; IEA:UniProtKB-KW.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF00072; Response_reg; 1.
DR   ProDom; PD000039; Response_reg; 1.
DR   SMART; SM00448; REC; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytokinin signaling pathway; Nucleus;
KW   Phosphoprotein; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN         1    259       Two-component response regulator ARR4.
FT                                /FTId=PRO_0000081425.
FT   DOMAIN       35    162       Response regulatory.
FT   COMPBIAS    179    246       Ser-rich.
FT   MOD_RES      95     95       4-aspartylphosphate (By similarity).
SQ   SEQUENCE   259 AA;  28297 MW;  557A4E2DA51948F5 CRC64;
     MARDGGVSCL RRSEMMSVGG IGGIESAPLD LDEVHVLAVD DSLVDRIVIE RLLRITSCKV
     TAVDSGWRAL EFLGLDNEKA SAEFDRLKVD LIITDYCMPG MTGYELLKKI KESSNFREVP
     VVIMSSENVL TRIDRCLEEG AQDFLLKPVK LADVKRLRSH LTKDVKLSNG NKRKLPEDSS
     SVNSSLPPPS PPLTISPESS PPLTVSTESS DSSPPLSPVE IFSTSPLSSP IDDEDDDVLT
     SSSEESPIRR QKMRSPGLD
//