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Protein

Proliferating cell nuclear antigen

Gene

PCNA

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi61 – 8020Sequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cell nuclear antigen
Short name:
PCNA
Gene namesi
Name:PCNA
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Proliferating cell nuclear antigenPRO_0000149188Add
BLAST

Proteomic databases

PRIDEiO82797.

Structurei

3D structure databases

ProteinModelPortaliO82797.
SMRiO82797. Positions 1-259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.Curated

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch.
InterProiIPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
[Graphical view]
PANTHERiPTHR11352. PTHR11352. 1 hit.
PfamiPF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
[Graphical view]
PRINTSiPR00339. PCNACYCLIN.
TIGRFAMsiTIGR00590. pcna. 1 hit.
PROSITEiPS01251. PCNA_1. 1 hit.
PS00293. PCNA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O82797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELRLVQGS LLKKVLESIK DLVNDANFDC SATGFSLQAM DSSHVALVAL
60 70 80 90 100
LLRSEGFEHY RCDRNISMGM NLANMAKMLK CAGNDDIITL KADDGSDTVT
110 120 130 140 150
FMFESPTQDK IADFEMKLMD IDSEHLGIPE AEYHAIVRMP SAEFSRICKD
160 170 180 190 200
LSSIGDTVVI SVTKEGVKFS TRGDIGTANI VCRQNTTVDK PEEATVIEMN
210 220 230 240 250
EPVSLTFALR YLNSFTKATP LSNTVTISLS SELPVVVEYK IAEMGYIRFY
260
LAPKIEEDEE ETKP
Length:264
Mass (Da):29,272
Last modified:November 1, 1998 - v1
Checksum:iD708552B805C199C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085197 mRNA. Translation: AAC34126.1.
AF038875 mRNA. Translation: AAC27992.1.
AB025029 mRNA. Translation: BAA76349.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085197 mRNA. Translation: AAC34126.1.
AF038875 mRNA. Translation: AAC27992.1.
AB025029 mRNA. Translation: BAA76349.1.

3D structure databases

ProteinModelPortaliO82797.
SMRiO82797. Positions 1-259.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO82797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch.
InterProiIPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
[Graphical view]
PANTHERiPTHR11352. PTHR11352. 1 hit.
PfamiPF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
[Graphical view]
PRINTSiPR00339. PCNACYCLIN.
TIGRFAMsiTIGR00590. pcna. 1 hit.
PROSITEiPS01251. PCNA_1. 1 hit.
PS00293. PCNA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Tomato leaf curl geminivirus replication is cell cycle dependent."
    Padidam M., Beachy R.N., Fauquet C.M.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Bright Yellow 2.
  2. "Nucleotide sequence of an Nicotiana tabacum cDNA clone encoding a homolog of proliferating cell nuclear antigen."
    Park S.-C., Park E.-H., Cho J.W.
    Plant Gene Register PGR99-022
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Ito M.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Bright Yellow 2.

Entry informationi

Entry nameiPCNA_TOBAC
AccessioniPrimary (citable) accession number: O82797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 14, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.