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Protein

MADS-box protein AGL24

Gene

AGL24

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription activator that mediates floral transition in response to vernalization. Promotes inflorescence fate in apical meristems. Acts in a dosage-dependent manner. Probably involved in the transduction of RLK-mediated signaling (e.g. IMK3 pathway). Together with AP1 and SVP, controls the identity of the floral meristem and regulates expression of class B, C and E genes. When associated with SOC1, mediates effect of gibberellins on flowering under short-day conditions, and regulates the expression of LEAFY (LFY), which links floral induction and floral development. Confers inflorescence characteristics to floral primordia and early flowering.9 Publications

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TAIR
  • protein heterodimerization activity Source: TAIR
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: InterPro
  • sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • floral whorl development Source: TAIR
  • maintenance of inflorescence meristem identity Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: InterPro
  • positive regulation of vernalization response Source: UniProtKB
  • protein import into nucleus, translocation Source: UniProtKB
  • regulation of timing of transition from vegetative to reproductive phase Source: TAIR
  • response to gibberellin Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Flowering, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
MADS-box protein AGL24
Alternative name(s):
Protein AGAMOUS-LIKE 24
Gene namesi
Name:AGL24
Ordered Locus Names:At4g24540
ORF Names:F22K18.260
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G24540
TAIRilocus:2121924 AT4G24540

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Delayed flowering.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003929261 – 220MADS-box protein AGL24Add BLAST220

Post-translational modificationi

Phosphorylated by IMK3. Induced by vernalization.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO82794

Expressioni

Tissue specificityi

Mostly expressed in shoot apical meristems, including floral meristems. Also detected in stems, seedlings, leaves, flowers and siliques, and, to a lower extent, in roots.4 Publications

Developmental stagei

During vegetative phase, expressed in the entire shoot apical meristem and in emerging leaf primordia. During floral transition, gradually detectable in the transitional shoot apex and young cauline leaves. Detected in the inflorescence meristem. Present throughout the tunica (superficial layers) of the floral meristem during early stages of flower development. Later disappears prior to emergence of sepal primordia. At later stages of floral development, weakly expressed in the distal parts of stamens and carpels. Then restricted to pollen and the adaxial surface of the gynoecium.3 Publications

Inductioni

Induced by vernalization in a FLC-independent manner. Repressed by the floral homeotic genes AP1, LFY and SEP3 in emerging floral meristems to establish a floral identity and prevent inflorescence fate. Up-regulated at the shoot apex by SOC1.5 Publications

Gene expression databases

ExpressionAtlasiO82794 baseline and differential
GenevisibleiO82794 AT

Interactioni

Subunit structurei

Interacts with IMK3/MRLK. Forms a homodimer and heterodimer with SOC1, AP1 and SVP through MADS-box domain. Interacts with the SEU-LUG corepressor complex when complexed to AP1. Interacts with AGL15 and AGL16.4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein heterodimerization activity Source: TAIR

Protein-protein interaction databases

BioGridi13845, 18 interactors
ELMiO82794
IntActiO82794, 15 interactors
STRINGi3702.AT4G24540.1

Structurei

3D structure databases

ProteinModelPortaliO82794
SMRiO82794
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61MADS-boxPROSITE-ProRule annotationAdd BLAST61
Domaini87 – 177K-boxPROSITE-ProRule annotationAdd BLAST91

Phylogenomic databases

eggNOGiKOG0014 Eukaryota
COG5068 LUCA
HOGENOMiHOG000155301
InParanoidiO82794
OMAiTTMEMAK
OrthoDBiEOG09360NRU
PhylomeDBiO82794

Family and domain databases

CDDicd00265 MADS_MEF2_like, 1 hit
Gene3Di3.40.1810.10, 1 hit
InterProiView protein in InterPro
IPR033896 MADS_MEF2-like
IPR002487 TF_Kbox
IPR002100 TF_MADSbox
IPR036879 TF_MADSbox_sf
PfamiView protein in Pfam
PF01486 K-box, 1 hit
PF00319 SRF-TF, 1 hit
PRINTSiPR00404 MADSDOMAIN
SMARTiView protein in SMART
SM00432 MADS, 1 hit
SUPFAMiSSF55455 SSF55455, 1 hit
PROSITEiView protein in PROSITE
PS51297 K_BOX, 1 hit
PS00350 MADS_BOX_1, 1 hit
PS50066 MADS_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O82794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAREKIRIKK IDNITARQVT FSKRRRGIFK KADELSVLCD ADVALIIFSA
60 70 80 90 100
TGKLFEFSSS RMRDILGRYS LHASNINKLM DPPSTHLRLE NCNLSRLSKE
110 120 130 140 150
VEDKTKQLRK LRGEDLDGLN LEELQRLEKL LESGLSRVSE KKGECVMSQI
160 170 180 190 200
FSLEKRGSEL VDENKRLRDK LETLERAKLT TLKEALETES VTTNVSSYDS
210 220
GTPLEDDSDT SLKLGLPSWE
Length:220
Mass (Da):25,064
Last modified:November 1, 1998 - v1
Checksum:iC58CB708B3AC99EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005158 mRNA Translation: AAC63139.1
AF005159 Genomic DNA Translation: AAC63140.1
AL035356 Genomic DNA Translation: CAA23009.1
AL161561 Genomic DNA Translation: CAB79364.1
CP002687 Genomic DNA Translation: AEE84922.1
BT025171 mRNA Translation: ABE77409.1
AB493697 mRNA Translation: BAH30535.1
PIRiT05580
T51827
RefSeqiNP_194185.1, NM_118587.6
UniGeneiAt.4507

Genome annotation databases

EnsemblPlantsiAT4G24540.1; AT4G24540.1; AT4G24540
GeneIDi828556
GrameneiAT4G24540.1; AT4G24540.1; AT4G24540
KEGGiath:AT4G24540

Similar proteinsi

Entry informationi

Entry nameiAGL24_ARATH
AccessioniPrimary (citable) accession number: O82794
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names

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