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Protein

MADS-box protein AGL24

Gene

AGL24

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription activator that mediates floral transition in response to vernalization. Promotes inflorescence fate in apical meristems. Acts in a dosage-dependent manner. Probably involved in the transduction of RLK-mediated signaling (e.g. IMK3 pathway). Together with AP1 and SVP, controls the identity of the floral meristem and regulates expression of class B, C and E genes. When associated with SOC1, mediates effect of gibberellins on flowering under short-day conditions, and regulates the expression of LEAFY (LFY), which links floral induction and floral development. Confers inflorescence characteristics to floral primordia and early flowering.9 Publications

GO - Molecular functioni

  • protein heterodimerization activity Source: TAIR
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: InterPro
  • sequence-specific DNA binding Source: TAIR
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • floral whorl development Source: TAIR
  • maintenance of inflorescence meristem identity Source: UniProtKB
  • MAPK cascade Source: InterPro
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: InterPro
  • positive regulation of vernalization response Source: UniProtKB
  • protein import into nucleus, translocation Source: UniProtKB
  • regulation of timing of transition from vegetative to reproductive phase Source: TAIR
  • response to gibberellin Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Flowering, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MADS-box protein AGL24
Alternative name(s):
Protein AGAMOUS-LIKE 24
Gene namesi
Name:AGL24
Ordered Locus Names:At4g24540
ORF Names:F22K18.260
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G24540.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Translocation from the cytoplasm to the nucleus in the presence of IMK3.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Delayed flowering.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003929261 – 220MADS-box protein AGL24Add BLAST220

Post-translational modificationi

Phosphorylated by IMK3. Induced by vernalization.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO82794.

Expressioni

Tissue specificityi

Mostly expressed in shoot apical meristems, including floral meristems. Also detected in stems, seedlings, leaves, flowers and siliques, and, to a lower extent, in roots.4 Publications

Developmental stagei

During vegetative phase, expressed in the entire shoot apical meristem and in emerging leaf primordia. During floral transition, gradually detectable in the transitional shoot apex and young cauline leaves. Detected in the inflorescence meristem. Present throughout the tunica (superficial layers) of the floral meristem during early stages of flower development. Later disappears prior to emergence of sepal primordia. At later stages of floral development, weakly expressed in the distal parts of stamens and carpels. Then restricted to pollen and the adaxial surface of the gynoecium.3 Publications

Inductioni

Induced by vernalization in a FLC-independent manner. Repressed by the floral homeotic genes AP1, LFY and SEP3 in emerging floral meristems to establish a floral identity and prevent inflorescence fate. Up-regulated at the shoot apex by SOC1.5 Publications

Gene expression databases

GenevisibleiO82794. AT.

Interactioni

Subunit structurei

Interacts with IMK3/MRLK. Forms a homodimer and heterodimer with SOC1, AP1 and SVP through MADS-box domain. Interacts with the SEU-LUG corepressor complex when complexed to AP1. Interacts with AGL15 and AGL16.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AGL8Q388763EBI-592083,EBI-621912
AP1P356314EBI-592083,EBI-592003
PIN1Q9SL424EBI-592083,EBI-2618990

GO - Molecular functioni

  • protein heterodimerization activity Source: TAIR

Protein-protein interaction databases

BioGridi13845. 18 interactors.
IntActiO82794. 13 interactors.
STRINGi3702.AT4G24540.1.

Structurei

3D structure databases

ProteinModelPortaliO82794.
SMRiO82794.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61MADS-boxPROSITE-ProRule annotationAdd BLAST61
Domaini87 – 177K-boxPROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Contains 1 K-box domain.PROSITE-ProRule annotation
Contains 1 MADS-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000155301.
InParanoidiO82794.
OMAiSEKKGEC.
OrthoDBiEOG09360NRU.
PhylomeDBiO82794.

Family and domain databases

CDDicd00265. MADS_MEF2_like. 1 hit.
InterProiIPR033896. MADS_MEF2-like.
IPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
[Graphical view]
PfamiPF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O82794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAREKIRIKK IDNITARQVT FSKRRRGIFK KADELSVLCD ADVALIIFSA
60 70 80 90 100
TGKLFEFSSS RMRDILGRYS LHASNINKLM DPPSTHLRLE NCNLSRLSKE
110 120 130 140 150
VEDKTKQLRK LRGEDLDGLN LEELQRLEKL LESGLSRVSE KKGECVMSQI
160 170 180 190 200
FSLEKRGSEL VDENKRLRDK LETLERAKLT TLKEALETES VTTNVSSYDS
210 220
GTPLEDDSDT SLKLGLPSWE
Length:220
Mass (Da):25,064
Last modified:November 1, 1998 - v1
Checksum:iC58CB708B3AC99EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005158 mRNA. Translation: AAC63139.1.
AF005159 Genomic DNA. Translation: AAC63140.1.
AL035356 Genomic DNA. Translation: CAA23009.1.
AL161561 Genomic DNA. Translation: CAB79364.1.
CP002687 Genomic DNA. Translation: AEE84922.1.
BT025171 mRNA. Translation: ABE77409.1.
AB493697 mRNA. Translation: BAH30535.1.
PIRiT05580.
T51827.
RefSeqiNP_194185.1. NM_118587.6.
UniGeneiAt.4507.

Genome annotation databases

EnsemblPlantsiAT4G24540.1; AT4G24540.1; AT4G24540.
GeneIDi828556.
GrameneiAT4G24540.1; AT4G24540.1; AT4G24540.
KEGGiath:AT4G24540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005158 mRNA. Translation: AAC63139.1.
AF005159 Genomic DNA. Translation: AAC63140.1.
AL035356 Genomic DNA. Translation: CAA23009.1.
AL161561 Genomic DNA. Translation: CAB79364.1.
CP002687 Genomic DNA. Translation: AEE84922.1.
BT025171 mRNA. Translation: ABE77409.1.
AB493697 mRNA. Translation: BAH30535.1.
PIRiT05580.
T51827.
RefSeqiNP_194185.1. NM_118587.6.
UniGeneiAt.4507.

3D structure databases

ProteinModelPortaliO82794.
SMRiO82794.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi13845. 18 interactors.
IntActiO82794. 13 interactors.
STRINGi3702.AT4G24540.1.

Proteomic databases

PaxDbiO82794.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G24540.1; AT4G24540.1; AT4G24540.
GeneIDi828556.
GrameneiAT4G24540.1; AT4G24540.1; AT4G24540.
KEGGiath:AT4G24540.

Organism-specific databases

TAIRiAT4G24540.

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000155301.
InParanoidiO82794.
OMAiSEKKGEC.
OrthoDBiEOG09360NRU.
PhylomeDBiO82794.

Miscellaneous databases

PROiO82794.

Gene expression databases

GenevisibleiO82794. AT.

Family and domain databases

CDDicd00265. MADS_MEF2_like. 1 hit.
InterProiIPR033896. MADS_MEF2-like.
IPR002487. TF_Kbox.
IPR002100. TF_MADSbox.
[Graphical view]
PfamiPF01486. K-box. 1 hit.
PF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS51297. K_BOX. 1 hit.
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGL24_ARATH
AccessioniPrimary (citable) accession number: O82794
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.