UniProtKB - O82794 (AGL24_ARATH)
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Protein
MADS-box protein AGL24
Gene
AGL24
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Transcription activator that mediates floral transition in response to vernalization. Promotes inflorescence fate in apical meristems. Acts in a dosage-dependent manner. Probably involved in the transduction of RLK-mediated signaling (e.g. IMK3 pathway). Together with AP1 and SVP, controls the identity of the floral meristem and regulates expression of class B, C and E genes. When associated with SOC1, mediates effect of gibberellins on flowering under short-day conditions, and regulates the expression of LEAFY (LFY), which links floral induction and floral development. Confers inflorescence characteristics to floral primordia and early flowering.9 Publications
GO - Molecular functioni
- protein heterodimerization activity Source: TAIR
- RNA polymerase II regulatory region sequence-specific DNA binding Source: InterPro
- sequence-specific DNA binding Source: TAIR
- transcription factor activity, sequence-specific DNA binding Source: TAIR
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- floral whorl development Source: TAIR
- maintenance of inflorescence meristem identity Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription from RNA polymerase II promoter Source: InterPro
- positive regulation of vernalization response Source: UniProtKB
- protein import into nucleus, translocation Source: UniProtKB
- regulation of timing of transition from vegetative to reproductive phase Source: TAIR
- response to gibberellin Source: UniProtKB
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
| Molecular function | Activator, Developmental protein, DNA-binding |
| Biological process | Differentiation, Flowering, Transcription, Transcription regulation |
Names & Taxonomyi
| Protein namesi | Recommended name: MADS-box protein AGL24Alternative name(s): Protein AGAMOUS-LIKE 24 |
| Gene namesi | Name:AGL24 Ordered Locus Names:At4g24540 ORF Names:F22K18.260 |
| Organismi | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic identifieri | 3702 [NCBI] |
| Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
| Proteomesi |
|
Organism-specific databases
| Araporti | AT4G24540. |
| TAIRi | locus:2121924. AT4G24540. |
Pathology & Biotechi
Disruption phenotypei
Delayed flowering.1 Publication
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000392926 | 1 – 220 | MADS-box protein AGL24Add BLAST | 220 |
Post-translational modificationi
Phosphorylated by IMK3. Induced by vernalization.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
| PaxDbi | O82794. |
Expressioni
Tissue specificityi
Mostly expressed in shoot apical meristems, including floral meristems. Also detected in stems, seedlings, leaves, flowers and siliques, and, to a lower extent, in roots.4 Publications
Developmental stagei
During vegetative phase, expressed in the entire shoot apical meristem and in emerging leaf primordia. During floral transition, gradually detectable in the transitional shoot apex and young cauline leaves. Detected in the inflorescence meristem. Present throughout the tunica (superficial layers) of the floral meristem during early stages of flower development. Later disappears prior to emergence of sepal primordia. At later stages of floral development, weakly expressed in the distal parts of stamens and carpels. Then restricted to pollen and the adaxial surface of the gynoecium.3 Publications
Inductioni
Induced by vernalization in a FLC-independent manner. Repressed by the floral homeotic genes AP1, LFY and SEP3 in emerging floral meristems to establish a floral identity and prevent inflorescence fate. Up-regulated at the shoot apex by SOC1.5 Publications
Gene expression databases
| ExpressionAtlasi | O82794. baseline and differential. |
| Genevisiblei | O82794. AT. |
Interactioni
Subunit structurei
Interacts with IMK3/MRLK. Forms a homodimer and heterodimer with SOC1, AP1 and SVP through MADS-box domain. Interacts with the SEU-LUG corepressor complex when complexed to AP1. Interacts with AGL15 and AGL16.4 Publications
Binary interactionsi
GO - Molecular functioni
- protein heterodimerization activity Source: TAIR
Protein-protein interaction databases
| BioGridi | 13845. 18 interactors. |
| IntActi | O82794. 13 interactors. |
| STRINGi | 3702.AT4G24540.1. |
Structurei
3D structure databases
| ProteinModelPortali | O82794. |
| SMRi | O82794. |
| ModBasei | Search... |
| MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Domaini | 1 – 61 | MADS-boxPROSITE-ProRule annotationAdd BLAST | 61 | |
| Domaini | 87 – 177 | K-boxPROSITE-ProRule annotationAdd BLAST | 91 |
Phylogenomic databases
| eggNOGi | KOG0014. Eukaryota. COG5068. LUCA. |
| HOGENOMi | HOG000155301. |
| InParanoidi | O82794. |
| OMAi | TTMEMAK. |
| OrthoDBi | EOG09360NRU. |
| PhylomeDBi | O82794. |
Family and domain databases
| CDDi | cd00265. MADS_MEF2_like. 1 hit. |
| Gene3Di | 3.40.1810.10. 1 hit. |
| InterProi | View protein in InterPro IPR033896. MADS_MEF2-like. IPR002487. TF_Kbox. IPR002100. TF_MADSbox. |
| Pfami | View protein in Pfam PF01486. K-box. 1 hit. PF00319. SRF-TF. 1 hit. |
| PRINTSi | PR00404. MADSDOMAIN. |
| SMARTi | View protein in SMART SM00432. MADS. 1 hit. |
| SUPFAMi | SSF55455. SSF55455. 1 hit. |
| PROSITEi | View protein in PROSITE PS51297. K_BOX. 1 hit. PS00350. MADS_BOX_1. 1 hit. PS50066. MADS_BOX_2. 1 hit. |
Sequencei
Sequence statusi: Complete.
O82794-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAREKIRIKK IDNITARQVT FSKRRRGIFK KADELSVLCD ADVALIIFSA
60 70 80 90 100
TGKLFEFSSS RMRDILGRYS LHASNINKLM DPPSTHLRLE NCNLSRLSKE
110 120 130 140 150
VEDKTKQLRK LRGEDLDGLN LEELQRLEKL LESGLSRVSE KKGECVMSQI
160 170 180 190 200
FSLEKRGSEL VDENKRLRDK LETLERAKLT TLKEALETES VTTNVSSYDS
210 220
GTPLEDDSDT SLKLGLPSWE
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF005158 mRNA. Translation: AAC63139.1. AF005159 Genomic DNA. Translation: AAC63140.1. AL035356 Genomic DNA. Translation: CAA23009.1. AL161561 Genomic DNA. Translation: CAB79364.1. CP002687 Genomic DNA. Translation: AEE84922.1. BT025171 mRNA. Translation: ABE77409.1. AB493697 mRNA. Translation: BAH30535.1. |
| PIRi | T05580. T51827. |
| RefSeqi | NP_194185.1. NM_118587.6. |
| UniGenei | At.4507. |
Genome annotation databases
| EnsemblPlantsi | AT4G24540.1; AT4G24540.1; AT4G24540. |
| GeneIDi | 828556. |
| Gramenei | AT4G24540.1; AT4G24540.1; AT4G24540. |
| KEGGi | ath:AT4G24540. |
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | AGL24_ARATH | |
| Accessioni | O82794Primary (citable) accession number: O82794 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 23, 2010 |
| Last sequence update: | November 1, 1998 | |
| Last modified: | July 5, 2017 | |
| This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Plant Protein Annotation Program | |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names
