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O82782 (HIS3_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic

EC=5.3.1.16
Alternative name(s):
5-proFAR isomerase
BBM II
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Protein ALBINO AND PALE GREEN 10
Protein HISTIDINE BIOSYNTHESIS 3
Gene names
Name:HISN3
Synonyms:APG10
Ordered Locus Names:At2g36230
ORF Names:F2H17.16
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.

Subcellular location

Plastidchloroplast.

Sequence similarities

Belongs to the HisA/HisF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 6161Chloroplast Potential
Chain62 – 3042431-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic
PRO_0000013445

Sequences

Sequence LengthMass (Da)Tools
O82782 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: AB17690E4635721B

FASTA30433,365
        10         20         30         40         50         60 
MRTLSSQLYS NGGLTWFQKK NQSSLFIKHL RVSKPSRVQL ISAVQFRPCI DIHKGKVKQI 

        70         80         90        100        110        120 
VGSTLRDLKE DGSVLVTNFE SDKSAEEYAK MYKEDGLTGG HVIMLGADPL SQAAAIGALH 

       130        140        150        160        170        180 
AYPGGLQVGG GINSENCMSY IEEGASHVIV TSYVFNNGKI DLERLKDIVS IVGKQRLILD 

       190        200        210        220        230        240 
LSCRKKDGRY AIVTDRWQKF SDVILDEKSL EFLGGFSDEF LVHGVDVEGK KLGIDEELVA 

       250        260        270        280        290        300 
LLGNYSPIPV TYAGGVTVMD DVERIKDAGK GRVDVTVGSA LDIFGGNLPY KDVVAWHHKQ 


HSLH 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of the gene encoding N'-[(5'-phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (BBM II) isomerase from Arabidopsis thaliana."
Fujimori K., Tada S., Kanai S., Ohta D.
Mol. Gen. Genet. 259:216-223(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: cv. Columbia.
[2]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Functional annotation of a full-length Arabidopsis cDNA collection."
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K.
Science 296:141-145(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[6]"Histidine biosynthesis in plants."
Stepansky A., Leustek T.
Amino Acids 30:127-142(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[7]"Genetic dissection of histidine biosynthesis in Arabidopsis."
Muralla R., Sweeney C., Stepansky A., Leustek T., Meinke D.
Plant Physiol. 144:890-903(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB008929 Genomic DNA. Translation: BAA32457.1.
AB006139 mRNA. Translation: BAA32456.1.
AC006921 Genomic DNA. Translation: AAD21442.1.
CP002685 Genomic DNA. Translation: AEC09219.1.
AK118659 mRNA. Translation: BAC43255.1.
AY140058 mRNA. Translation: AAM98199.1.
BT002552 mRNA. Translation: AAO00912.1.
PIRT51822.
RefSeqNP_181165.1. NM_129181.3.
UniGeneAt.20166.
At.66347.

3D structure databases

ProteinModelPortalO82782.
SMRO82782. Positions 45-300.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO82782. 1 interaction.
STRING3702.AT2G36230.1-P.

Proteomic databases

PaxDbO82782.
PRIDEO82782.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G36230.1; AT2G36230.1; AT2G36230.
GeneID818195.
KEGGath:AT2G36230.

Organism-specific databases

GeneFarm4312.
TAIRAT2G36230.

Phylogenomic databases

eggNOGCOG0106.
HOGENOMHOG000172261.
InParanoidO82782.
KOK01814.
OMAFVAMNKW.
PhylomeDBO82782.
ProtClustDBPLN02446.

Enzyme and pathway databases

BioCycARA:AT2G36230-MONOMER.
MetaCyc:AT2G36230-MONOMER.
UniPathwayUPA00031; UER00009.

Gene expression databases

ArrayExpressO82782.
GenevestigatorO82782.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR011858. HisA_euk.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERPTHR21169. PTHR21169. 1 hit.
PfamPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02129. hisA_euk. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHIS3_ARATH
AccessionPrimary (citable) accession number: O82782
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names