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O82782

- HIS3_ARATH

UniProt

O82782 - HIS3_ARATH

Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic

Gene

HISN3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

    Pathwayi

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: TAIR

    GO - Biological processi

    1. histidine biosynthetic process Source: TAIR

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    BioCyciARA:AT2G36230-MONOMER.
    MetaCyc:AT2G36230-MONOMER.
    UniPathwayiUPA00031; UER00009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic (EC:5.3.1.16)
    Alternative name(s):
    5-proFAR isomerase
    BBM II
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
    Protein ALBINO AND PALE GREEN 10
    Protein HISTIDINE BIOSYNTHESIS 3
    Gene namesi
    Name:HISN3
    Synonyms:APG10
    Ordered Locus Names:At2g36230
    ORF Names:F2H17.16
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G36230.

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: TAIR

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 6161ChloroplastSequence AnalysisAdd
    BLAST
    Chaini62 – 3042431-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplasticPRO_0000013445Add
    BLAST

    Proteomic databases

    PaxDbiO82782.
    PRIDEiO82782.

    Expressioni

    Gene expression databases

    ArrayExpressiO82782.
    GenevestigatoriO82782.

    Interactioni

    Protein-protein interaction databases

    IntActiO82782. 1 interaction.
    STRINGi3702.AT2G36230.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliO82782.
    SMRiO82782. Positions 45-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0106.
    HOGENOMiHOG000172261.
    InParanoidiO82782.
    KOiK01814.
    OMAiFVAMNKW.
    PhylomeDBiO82782.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR011858. HisA_euk.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PANTHERiPTHR21169. PTHR21169. 1 hit.
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02129. hisA_euk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O82782-1 [UniParc]FASTAAdd to Basket

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    MRTLSSQLYS NGGLTWFQKK NQSSLFIKHL RVSKPSRVQL ISAVQFRPCI    50
    DIHKGKVKQI VGSTLRDLKE DGSVLVTNFE SDKSAEEYAK MYKEDGLTGG 100
    HVIMLGADPL SQAAAIGALH AYPGGLQVGG GINSENCMSY IEEGASHVIV 150
    TSYVFNNGKI DLERLKDIVS IVGKQRLILD LSCRKKDGRY AIVTDRWQKF 200
    SDVILDEKSL EFLGGFSDEF LVHGVDVEGK KLGIDEELVA LLGNYSPIPV 250
    TYAGGVTVMD DVERIKDAGK GRVDVTVGSA LDIFGGNLPY KDVVAWHHKQ 300
    HSLH 304
    Length:304
    Mass (Da):33,365
    Last modified:November 1, 1998 - v1
    Checksum:iAB17690E4635721B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB008929 Genomic DNA. Translation: BAA32457.1.
    AB006139 mRNA. Translation: BAA32456.1.
    AC006921 Genomic DNA. Translation: AAD21442.1.
    CP002685 Genomic DNA. Translation: AEC09219.1.
    AK118659 mRNA. Translation: BAC43255.1.
    AY140058 mRNA. Translation: AAM98199.1.
    BT002552 mRNA. Translation: AAO00912.1.
    PIRiT51822.
    RefSeqiNP_181165.1. NM_129181.3.
    UniGeneiAt.20166.
    At.66347.

    Genome annotation databases

    EnsemblPlantsiAT2G36230.1; AT2G36230.1; AT2G36230.
    GeneIDi818195.
    KEGGiath:AT2G36230.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB008929 Genomic DNA. Translation: BAA32457.1 .
    AB006139 mRNA. Translation: BAA32456.1 .
    AC006921 Genomic DNA. Translation: AAD21442.1 .
    CP002685 Genomic DNA. Translation: AEC09219.1 .
    AK118659 mRNA. Translation: BAC43255.1 .
    AY140058 mRNA. Translation: AAM98199.1 .
    BT002552 mRNA. Translation: AAO00912.1 .
    PIRi T51822.
    RefSeqi NP_181165.1. NM_129181.3.
    UniGenei At.20166.
    At.66347.

    3D structure databases

    ProteinModelPortali O82782.
    SMRi O82782. Positions 45-300.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O82782. 1 interaction.
    STRINGi 3702.AT2G36230.1-P.

    Proteomic databases

    PaxDbi O82782.
    PRIDEi O82782.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G36230.1 ; AT2G36230.1 ; AT2G36230 .
    GeneIDi 818195.
    KEGGi ath:AT2G36230.

    Organism-specific databases

    GeneFarmi 4312.
    TAIRi AT2G36230.

    Phylogenomic databases

    eggNOGi COG0106.
    HOGENOMi HOG000172261.
    InParanoidi O82782.
    KOi K01814.
    OMAi FVAMNKW.
    PhylomeDBi O82782.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .
    BioCyci ARA:AT2G36230-MONOMER.
    MetaCyc:AT2G36230-MONOMER.

    Gene expression databases

    ArrayExpressi O82782.
    Genevestigatori O82782.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR011858. HisA_euk.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    PANTHERi PTHR21169. PTHR21169. 1 hit.
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02129. hisA_euk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the gene encoding N'-[(5'-phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (BBM II) isomerase from Arabidopsis thaliana."
      Fujimori K., Tada S., Kanai S., Ohta D.
      Mol. Gen. Genet. 259:216-223(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: cv. Columbia.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. Cited for: GENE FAMILY, NOMENCLATURE.
    7. "Genetic dissection of histidine biosynthesis in Arabidopsis."
      Muralla R., Sweeney C., Stepansky A., Leustek T., Meinke D.
      Plant Physiol. 144:890-903(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiHIS3_ARATH
    AccessioniPrimary (citable) accession number: O82782
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3