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Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic

Gene

HISN3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: TAIR

GO - Biological processi

  1. histidine biosynthetic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciARA:AT2G36230-MONOMER.
MetaCyc:AT2G36230-MONOMER.
UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic (EC:5.3.1.16)
Alternative name(s):
5-proFAR isomerase
BBM II
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Protein ALBINO AND PALE GREEN 10
Protein HISTIDINE BIOSYNTHESIS 3
Gene namesi
Name:HISN3
Synonyms:APG10
Ordered Locus Names:At2g36230
ORF Names:F2H17.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G36230.

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6161ChloroplastSequence AnalysisAdd
BLAST
Chaini62 – 3042431-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplasticPRO_0000013445Add
BLAST

Proteomic databases

PaxDbiO82782.
PRIDEiO82782.

Expressioni

Gene expression databases

ExpressionAtlasiO82782. baseline and differential.
GenevestigatoriO82782.

Interactioni

Protein-protein interaction databases

IntActiO82782. 1 interaction.
STRINGi3702.AT2G36230.1-P.

Structurei

3D structure databases

ProteinModelPortaliO82782.
SMRiO82782. Positions 45-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0106.
HOGENOMiHOG000172261.
InParanoidiO82782.
KOiK01814.
OMAiFVAMNKW.
PhylomeDBiO82782.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR011858. HisA_euk.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR21169. PTHR21169. 1 hit.
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02129. hisA_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O82782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLSSQLYS NGGLTWFQKK NQSSLFIKHL RVSKPSRVQL ISAVQFRPCI
60 70 80 90 100
DIHKGKVKQI VGSTLRDLKE DGSVLVTNFE SDKSAEEYAK MYKEDGLTGG
110 120 130 140 150
HVIMLGADPL SQAAAIGALH AYPGGLQVGG GINSENCMSY IEEGASHVIV
160 170 180 190 200
TSYVFNNGKI DLERLKDIVS IVGKQRLILD LSCRKKDGRY AIVTDRWQKF
210 220 230 240 250
SDVILDEKSL EFLGGFSDEF LVHGVDVEGK KLGIDEELVA LLGNYSPIPV
260 270 280 290 300
TYAGGVTVMD DVERIKDAGK GRVDVTVGSA LDIFGGNLPY KDVVAWHHKQ

HSLH
Length:304
Mass (Da):33,365
Last modified:November 1, 1998 - v1
Checksum:iAB17690E4635721B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008929 Genomic DNA. Translation: BAA32457.1.
AB006139 mRNA. Translation: BAA32456.1.
AC006921 Genomic DNA. Translation: AAD21442.1.
CP002685 Genomic DNA. Translation: AEC09219.1.
AK118659 mRNA. Translation: BAC43255.1.
AY140058 mRNA. Translation: AAM98199.1.
BT002552 mRNA. Translation: AAO00912.1.
PIRiT51822.
RefSeqiNP_181165.1. NM_129181.3.
UniGeneiAt.20166.
At.66347.

Genome annotation databases

EnsemblPlantsiAT2G36230.1; AT2G36230.1; AT2G36230.
GeneIDi818195.
KEGGiath:AT2G36230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008929 Genomic DNA. Translation: BAA32457.1.
AB006139 mRNA. Translation: BAA32456.1.
AC006921 Genomic DNA. Translation: AAD21442.1.
CP002685 Genomic DNA. Translation: AEC09219.1.
AK118659 mRNA. Translation: BAC43255.1.
AY140058 mRNA. Translation: AAM98199.1.
BT002552 mRNA. Translation: AAO00912.1.
PIRiT51822.
RefSeqiNP_181165.1. NM_129181.3.
UniGeneiAt.20166.
At.66347.

3D structure databases

ProteinModelPortaliO82782.
SMRiO82782. Positions 45-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO82782. 1 interaction.
STRINGi3702.AT2G36230.1-P.

Proteomic databases

PaxDbiO82782.
PRIDEiO82782.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G36230.1; AT2G36230.1; AT2G36230.
GeneIDi818195.
KEGGiath:AT2G36230.

Organism-specific databases

GeneFarmi4312.
TAIRiAT2G36230.

Phylogenomic databases

eggNOGiCOG0106.
HOGENOMiHOG000172261.
InParanoidiO82782.
KOiK01814.
OMAiFVAMNKW.
PhylomeDBiO82782.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00009.
BioCyciARA:AT2G36230-MONOMER.
MetaCyc:AT2G36230-MONOMER.

Gene expression databases

ExpressionAtlasiO82782. baseline and differential.
GenevestigatoriO82782.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR011858. HisA_euk.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR21169. PTHR21169. 1 hit.
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02129. hisA_euk. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the gene encoding N'-[(5'-phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (BBM II) isomerase from Arabidopsis thaliana."
    Fujimori K., Tada S., Kanai S., Ohta D.
    Mol. Gen. Genet. 259:216-223(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: cv. Columbia.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. Cited for: GENE FAMILY, NOMENCLATURE.
  7. "Genetic dissection of histidine biosynthesis in Arabidopsis."
    Muralla R., Sweeney C., Stepansky A., Leustek T., Meinke D.
    Plant Physiol. 144:890-903(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiHIS3_ARATH
AccessioniPrimary (citable) accession number: O82782
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.