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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial

Gene

SDH1-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial (SDH1-1), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (AXX17_At5g38380), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (AXX17_At3g29870), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial (SDH2-3), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial (SDH2-1), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (AXX17_At2g13790), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial (SDH2-2), Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial (SDH1-2), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (AXX17_At5g66760)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei264FADBy similarity1
Binding sitei285SubstrateBy similarity1
Binding sitei297SubstrateBy similarity1
Active sitei329Proton acceptorBy similarity1
Binding sitei396SubstrateBy similarity1
Binding sitei430FADBy similarity1
Binding sitei441SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi56 – 61FADBy similarity6
Nucleotide bindingi79 – 94FADBy similarityAdd BLAST16
Nucleotide bindingi446 – 447FADBy similarity2

GO - Molecular functioni

  • ATP binding Source: TAIR
  • cobalt ion binding Source: TAIR
  • electron carrier activity Source: GO_Central
  • flavin adenine dinucleotide binding Source: InterPro
  • succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  • succinate dehydrogenase activity Source: TAIR

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:AT5G66760-MONOMER.
UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial (EC:1.3.5.1By similarity)
Alternative name(s):
Flavoprotein subunit 1 of complex II
Short name:
FP
Gene namesi
Name:SDH1-1
Ordered Locus Names:At5g66760
ORF Names:MSN2.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G66760.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: TAIR
  • mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) Source: TAIR
  • mitochondrion Source: TAIR
  • respiratory chain complex II Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32MitochondrionSequence analysisAdd BLAST32
ChainiPRO_000015865933 – 634Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrialAdd BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87Tele-8alpha-FAD histidineBy similarity1

Proteomic databases

PaxDbiO82663.
PRIDEiO82663.

PTM databases

SwissPalmiO82663.

Expressioni

Tissue specificityi

Ubiquitous. Preferentially expressed in flowers and inflorescences.1 Publication

Gene expression databases

GenevisibleiO82663. AT.

Interactioni

Subunit structurei

Component of complex II composed of eight subunits in plants: four classical SDH subunits SDH1, SDH2, SDH3 and SDH4 (a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.), as well as four subunits unknown in mitochondria from bacteria and heterotrophic eukaryotes.1 Publication

Protein-protein interaction databases

BioGridi22051. 3 interactors.
IntActiO82663. 2 interactors.
MINTiMINT-8063231.
STRINGi3702.AT5G66760.1.

Structurei

3D structure databases

ProteinModelPortaliO82663.
SMRiO82663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2403. Eukaryota.
COG1053. LUCA.
HOGENOMiHOG000160475.
InParanoidiO82663.
KOiK00234.
OMAiGKNHNSV.
OrthoDBiEOG093604YT.
PhylomeDBiO82663.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O82663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRCVSRGFR APASKTSSLF DGVSGSRFSR FFSTGSTDTR SSYTIVDHTY
60 70 80 90 100
DAVVVGAGGA GLRAAIGLSE HGFNTACITK LFPTRSHTVA AQGGINAALG
110 120 130 140 150
NMSEDDWRWH MYDTVKGSDW LGDQDAIQYM CREAPKAVIE LENYGLPFSR
160 170 180 190 200
TEEGKIYQRA FGGQSLDFGK GGQAYRCACA ADRTGHALLH TLYGQAMKHN
210 220 230 240 250
TQFFVEYFAL DLLMASDGSC QGVIALNMED GTLHRFRSSQ TILATGGYGR
260 270 280 290 300
AYFSATSAHT CTGDGNAMVA RAGLPLQDLE FVQFHPTGIY GAGCLITEGS
310 320 330 340 350
RGEGGILRNS EGERFMERYA PTAKDLASRD VVSRSMTMEI REGRGVGPHK
360 370 380 390 400
DHIYLHLNHL PPEVLKERLP GISETAAIFA GVDVTKEPIP VLPTVHYNMG
410 420 430 440 450
GIPTNYHGEV VTIKGDDPDA VIPGLMAAGE AACASVHGAN RLGANSLLDI
460 470 480 490 500
VVFGRACANR VAEISKPGEK QKPLEKDAGE KTIAWLDRLR NSNGSLPTST
510 520 530 540 550
IRLNMQRIMQ NNAAVFRTQE TLEEGCQLID KAWESFGDVQ VKDRSMIWNS
560 570 580 590 600
DLIETLELEN LLINASITMH SAEARKESRG AHAREDFTKR EDGEWMKHTL
610 620 630
GYWEDEKVRL DYRPVHMDTL DDEIDTFPPK ARVY
Length:634
Mass (Da):69,656
Last modified:November 1, 1998 - v1
Checksum:iAECE471C7AD43B84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001809 mRNA. Translation: CAA05025.1.
AB018119 Genomic DNA. Translation: BAA97282.1.
CP002688 Genomic DNA. Translation: AED98260.1.
AF367341 mRNA. Translation: AAK32928.1.
AY045674 mRNA. Translation: AAK74032.1.
AF436833 mRNA. Translation: AAL32015.1.
AY124812 mRNA. Translation: AAM70521.1.
PIRiT51815.
RefSeqiNP_201477.1. NM_126074.3.
UniGeneiAt.22655.
At.67108.

Genome annotation databases

EnsemblPlantsiAT5G66760.1; AT5G66760.1; AT5G66760.
GeneIDi836809.
GrameneiAT5G66760.1; AT5G66760.1; AT5G66760.
KEGGiath:AT5G66760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001809 mRNA. Translation: CAA05025.1.
AB018119 Genomic DNA. Translation: BAA97282.1.
CP002688 Genomic DNA. Translation: AED98260.1.
AF367341 mRNA. Translation: AAK32928.1.
AY045674 mRNA. Translation: AAK74032.1.
AF436833 mRNA. Translation: AAL32015.1.
AY124812 mRNA. Translation: AAM70521.1.
PIRiT51815.
RefSeqiNP_201477.1. NM_126074.3.
UniGeneiAt.22655.
At.67108.

3D structure databases

ProteinModelPortaliO82663.
SMRiO82663.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi22051. 3 interactors.
IntActiO82663. 2 interactors.
MINTiMINT-8063231.
STRINGi3702.AT5G66760.1.

PTM databases

SwissPalmiO82663.

Proteomic databases

PaxDbiO82663.
PRIDEiO82663.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G66760.1; AT5G66760.1; AT5G66760.
GeneIDi836809.
GrameneiAT5G66760.1; AT5G66760.1; AT5G66760.
KEGGiath:AT5G66760.

Organism-specific databases

TAIRiAT5G66760.

Phylogenomic databases

eggNOGiKOG2403. Eukaryota.
COG1053. LUCA.
HOGENOMiHOG000160475.
InParanoidiO82663.
KOiK00234.
OMAiGKNHNSV.
OrthoDBiEOG093604YT.
PhylomeDBiO82663.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.
BioCyciMetaCyc:AT5G66760-MONOMER.

Miscellaneous databases

PROiO82663.

Gene expression databases

GenevisibleiO82663. AT.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDHA1_ARATH
AccessioniPrimary (citable) accession number: O82663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.