Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O82663

- SDHA1_ARATH

UniProt

O82663 - SDHA1_ARATH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial

Gene

SDH1-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FAD.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei264 – 2641FADBy similarity
Binding sitei285 – 2851SubstrateBy similarity
Binding sitei297 – 2971SubstrateBy similarity
Active sitei329 – 3291Proton acceptorBy similarity
Binding sitei396 – 3961SubstrateBy similarity
Binding sitei430 – 4301FADBy similarity
Binding sitei441 – 4411SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 616FADBy similarity
Nucleotide bindingi79 – 9416FADBy similarityAdd
BLAST
Nucleotide bindingi446 – 4472FADBy similarity

GO - Molecular functioni

  1. ATP binding Source: TAIR
  2. cobalt ion binding Source: TAIR
  3. flavin adenine dinucleotide binding Source: InterPro
  4. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  5. succinate dehydrogenase activity Source: TAIR

GO - Biological processi

  1. mitochondrial electron transport, succinate to ubiquinone Source: TAIR
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciARA:AT5G66760-MONOMER.
MetaCyc:AT5G66760-MONOMER.
UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Flavoprotein subunit 1 of complex II
Short name:
FP
Gene namesi
Name:SDH1-1
Ordered Locus Names:At5g66760
ORF Names:MSN2.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G66760.

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication

GO - Cellular componenti

  1. cell wall Source: TAIR
  2. mitochondrial respiratory chain complex II Source: TAIR
  3. mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3232MitochondrionSequence AnalysisAdd
BLAST
Chaini33 – 634602Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrialPRO_0000158659Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei87 – 871Tele-8alpha-FAD histidineBy similarity

Proteomic databases

PaxDbiO82663.
PRIDEiO82663.

Expressioni

Tissue specificityi

Ubiquitous. Preferentially expressed in flowers and inflorescences.1 Publication

Gene expression databases

GenevestigatoriO82663.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Protein-protein interaction databases

IntActiO82663. 2 interactions.
MINTiMINT-8063231.
STRINGi3702.AT5G66760.1-P.

Structurei

3D structure databases

ProteinModelPortaliO82663.
SMRiO82663. Positions 41-634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1053.
HOGENOMiHOG000160475.
InParanoidiO82663.
KOiK00234.
OMAiRDGPILQ.
PhylomeDBiO82663.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O82663 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWRCVSRGFR APASKTSSLF DGVSGSRFSR FFSTGSTDTR SSYTIVDHTY
60 70 80 90 100
DAVVVGAGGA GLRAAIGLSE HGFNTACITK LFPTRSHTVA AQGGINAALG
110 120 130 140 150
NMSEDDWRWH MYDTVKGSDW LGDQDAIQYM CREAPKAVIE LENYGLPFSR
160 170 180 190 200
TEEGKIYQRA FGGQSLDFGK GGQAYRCACA ADRTGHALLH TLYGQAMKHN
210 220 230 240 250
TQFFVEYFAL DLLMASDGSC QGVIALNMED GTLHRFRSSQ TILATGGYGR
260 270 280 290 300
AYFSATSAHT CTGDGNAMVA RAGLPLQDLE FVQFHPTGIY GAGCLITEGS
310 320 330 340 350
RGEGGILRNS EGERFMERYA PTAKDLASRD VVSRSMTMEI REGRGVGPHK
360 370 380 390 400
DHIYLHLNHL PPEVLKERLP GISETAAIFA GVDVTKEPIP VLPTVHYNMG
410 420 430 440 450
GIPTNYHGEV VTIKGDDPDA VIPGLMAAGE AACASVHGAN RLGANSLLDI
460 470 480 490 500
VVFGRACANR VAEISKPGEK QKPLEKDAGE KTIAWLDRLR NSNGSLPTST
510 520 530 540 550
IRLNMQRIMQ NNAAVFRTQE TLEEGCQLID KAWESFGDVQ VKDRSMIWNS
560 570 580 590 600
DLIETLELEN LLINASITMH SAEARKESRG AHAREDFTKR EDGEWMKHTL
610 620 630
GYWEDEKVRL DYRPVHMDTL DDEIDTFPPK ARVY
Length:634
Mass (Da):69,656
Last modified:November 1, 1998 - v1
Checksum:iAECE471C7AD43B84
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001809 mRNA. Translation: CAA05025.1.
AB018119 Genomic DNA. Translation: BAA97282.1.
CP002688 Genomic DNA. Translation: AED98260.1.
AF367341 mRNA. Translation: AAK32928.1.
AY045674 mRNA. Translation: AAK74032.1.
AF436833 mRNA. Translation: AAL32015.1.
AY124812 mRNA. Translation: AAM70521.1.
PIRiT51815.
RefSeqiNP_201477.1. NM_126074.2.
UniGeneiAt.22655.
At.67108.

Genome annotation databases

EnsemblPlantsiAT5G66760.1; AT5G66760.1; AT5G66760.
GeneIDi836809.
KEGGiath:AT5G66760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001809 mRNA. Translation: CAA05025.1 .
AB018119 Genomic DNA. Translation: BAA97282.1 .
CP002688 Genomic DNA. Translation: AED98260.1 .
AF367341 mRNA. Translation: AAK32928.1 .
AY045674 mRNA. Translation: AAK74032.1 .
AF436833 mRNA. Translation: AAL32015.1 .
AY124812 mRNA. Translation: AAM70521.1 .
PIRi T51815.
RefSeqi NP_201477.1. NM_126074.2.
UniGenei At.22655.
At.67108.

3D structure databases

ProteinModelPortali O82663.
SMRi O82663. Positions 41-634.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O82663. 2 interactions.
MINTi MINT-8063231.
STRINGi 3702.AT5G66760.1-P.

Proteomic databases

PaxDbi O82663.
PRIDEi O82663.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G66760.1 ; AT5G66760.1 ; AT5G66760 .
GeneIDi 836809.
KEGGi ath:AT5G66760.

Organism-specific databases

GeneFarmi 2175. 174.
TAIRi AT5G66760.

Phylogenomic databases

eggNOGi COG1053.
HOGENOMi HOG000160475.
InParanoidi O82663.
KOi K00234.
OMAi RDGPILQ.
PhylomeDBi O82663.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .
BioCyci ARA:AT5G66760-MONOMER.
MetaCyc:AT5G66760-MONOMER.

Miscellaneous databases

PROi O82663.

Gene expression databases

Genevestigatori O82663.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of succinyl-CoA-ligase from Arabidopsis thaliana."
    Machuy N., Klein M., Mueller-Roeber B.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. C24.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
    DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Proteomic approach to identify novel mitochondrial proteins in Arabidopsis."
    Kruft V., Eubel H., Jaensch L., Werhahn W., Braun H.-P.
    Plant Physiol. 127:1694-1710(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 160-170.
    Tissue: Leaf and Stem.
  6. "The four subunits of mitochondrial respiratory complex II are encoded by multiple nuclear genes and targeted to mitochondria in Arabidopsis thaliana."
    Figueroa P., Leon G., Elorza A., Holuigue L., Araya A., Jordana X.
    Plant Mol. Biol. 50:725-734(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, TISSUE SPECIFICITY.
  7. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.

Entry informationi

Entry nameiSDHA1_ARATH
AccessioniPrimary (citable) accession number: O82663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1998
Last modified: October 1, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3