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Protein

F-actin-capping protein subunit alpha

Gene

At3g05520

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin capping, Actin-binding

Enzyme and pathway databases

ReactomeiR-ATH-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
F-actin-capping protein subunit alpha
Alternative name(s):
CapZ alpha
Gene namesi
Ordered Locus Names:At3g05520
ORF Names:F22F7.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G05520

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002086401 – 308F-actin-capping protein subunit alphaAdd BLAST308

Proteomic databases

PaxDbiO82631
PRIDEiO82631

PTM databases

iPTMnetiO82631

Expressioni

Gene expression databases

ExpressionAtlasiO82631 baseline and differential
GenevisibleiO82631 AT

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi3702.AT3G05520.2

Structurei

3D structure databases

ProteinModelPortaliO82631
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0836 Eukaryota
ENOG410ZAWX LUCA
HOGENOMiHOG000036539
InParanoidiO82631
KOiK10364
PhylomeDBiO82631

Family and domain databases

InterProiView protein in InterPro
IPR002189 CapZ_alpha
IPR037282 CapZ_alpha/beta
IPR017865 F-actin_cap_asu_CS
PANTHERiPTHR10653 PTHR10653, 1 hit
PfamiView protein in Pfam
PF01267 F-actin_cap_A, 1 hit
PRINTSiPR00191 FACTINCAPA
SUPFAMiSSF90096 SSF90096, 1 hit
PROSITEiView protein in PROSITE
PS00748 F_ACTIN_CAPPING_A_1, 1 hit
PS00749 F_ACTIN_CAPPING_A_2, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: O82631-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADEEDELLE TELSYDQKKE IAKWFFLNAP AGEINYVAKD LKAVLSDEEV
60 70 80 90 100
YNEAAMEAFP VYNKTHMICL EMPSGAGDVI VSSYSEINEN EYLDPRTAQV
110 120 130 140 150
AIVDHVKQIC TKVRPANDEE LPSLYIEEYR YALDAEIQRY VSESYPKGMS
160 170 180 190 200
AVNCVKGKDN EGPGSDFELV VIITAMRLSP QNFCNGSWRS VWNIDFQDES
210 220 230 240 250
QVLDIKGKLQ VGAHYFEEGN VELDAKKDFQ DSTIFQSADD CAIAIANIIR
260 270 280 290 300
HHETEYLASL EVAYSKLPDN TFKDLRRKLP VTRTLFPWQN TLQFSLTREV

EKELGLGK
Length:308
Mass (Da):35,038
Last modified:March 27, 2002 - v2
Checksum:i81BA92AE0DF39B41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160N → T in CAA05054 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001855 mRNA Translation: CAA05054.1
AC009606 Genomic DNA Translation: AAF64531.1
CP002686 Genomic DNA Translation: AEE74252.1
PIRiT51820
RefSeqiNP_187203.1, NM_111425.5 [O82631-1]
UniGeneiAt.8

Genome annotation databases

EnsemblPlantsiAT3G05520.1; AT3G05520.1; AT3G05520 [O82631-1]
AT3G05520.2; AT3G05520.2; AT3G05520
GeneIDi819717
GrameneiAT3G05520.1; AT3G05520.1; AT3G05520 [O82631-1]
AT3G05520.2; AT3G05520.2; AT3G05520
KEGGiath:AT3G05520

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCAPZA_ARATH
AccessioniPrimary (citable) accession number: O82631
Secondary accession number(s): Q9MA66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 27, 2002
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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