Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aquaporin TIP1-3

Gene

TIP1-3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential aquaporin, which may facilitate the transport of water and small neutral solutes across cell membranes.By similarity

GO - Molecular functioni

  • glycerol channel activity Source: GO_Central
  • urea transmembrane transporter activity Source: TAIR
  • water channel activity Source: TAIR

GO - Biological processi

  • cellular water homeostasis Source: GO_Central
  • ion transmembrane transport Source: GO_Central
  • urea transport Source: TAIR
  • water transport Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Stress response, Transport

Enzyme and pathway databases

ReactomeiR-ATH-1237044. Erythrocytes take up carbon dioxide and release oxygen.
R-ATH-1247673. Erythrocytes take up oxygen and release carbon dioxide.
R-ATH-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-ATH-432047. Passive transport by Aquaporins.

Protein family/group databases

TCDBi1.A.8.10.6. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin TIP1-3
Alternative name(s):
Gamma-tonoplast intrinsic protein 3
Short name:
Gamma-TIP3
Tonoplast intrinsic protein 1-3
Short name:
AtTIP1;3
Cleaved into the following chain:
Gene namesi
Name:TIP1-3
Ordered Locus Names:At4g01470
ORF Names:F11O4.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G01470.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini44 – 55VacuolarSequence analysisAdd BLAST12
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 114CytoplasmicSequence analysisAdd BLAST38
Transmembranei115 – 135Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini136 – 143VacuolarSequence analysis8
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 170CytoplasmicSequence analysis6
Transmembranei171 – 191Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini192 – 219VacuolarSequence analysisAdd BLAST28
Transmembranei220 – 240Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini241 – 252CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640101 – 252Aquaporin TIP1-3Add BLAST252
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004257582 – 252Aquaporin TIP1-3, N-terminally processedAdd BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO82598.

Expressioni

Inductioni

By dehydration. Not affected by water stress.

Gene expression databases

GenevisibleiO82598. AT.

Interactioni

Subunit structurei

Interacts with cucumber mosaic virus (CMV) Protein 1a.1 Publication

Protein-protein interaction databases

BioGridi13342. 1 interactor.
STRINGi3702.AT4G01470.1.

Structurei

3D structure databases

ProteinModelPortaliO82598.
SMRiO82598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi85 – 87NPA 13
Motifi199 – 201NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
HOGENOMiHOG000288286.
InParanoidiO82598.
KOiK09873.
OMAiMAYGKLT.
OrthoDBiEOG09360J95.
PhylomeDBiO82598.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O82598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPINRIAIGT PGEASRPDAI RAAFAEFFSM VIFVFAGQGS GMAYGKLTGD
60 70 80 90 100
GPATPAGLVA ASLSHAFALF VAVSVGANVS GGHVNPAVTF GAFIGGNITL
110 120 130 140 150
LRAILYWIAQ LLGAVVACLL LKVSTGGMET AAFSLSYGVT PWNAVVFEIV
160 170 180 190 200
MTFGLVYTVY ATAVDPKKGD IGIIAPLAIG LIVGANILVG GAFDGASMNP
210 220 230 240 250
AVSFGPAVVS WIWTNHWVYW VGPFIGAAIA AIVYDTIFIG SNGHEPLPSN

DF
Length:252
Mass (Da):25,914
Last modified:November 1, 1998 - v1
Checksum:iF2FCC1D9DA44A76A
GO

Sequence cautioni

The sequence ABK28617 differs from that shown. Reason: Erroneous termination at position 253. Translated as stop.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096370 Genomic DNA. Translation: AAC62778.1.
AL161492 Genomic DNA. Translation: CAB77717.1.
CP002687 Genomic DNA. Translation: AEE82031.1.
DQ446793 mRNA. Translation: ABE66039.1.
DQ653172 mRNA. Translation: ABK28617.1. Sequence problems.
PIRiT01947.
RefSeqiNP_192056.1. NM_116377.2.
UniGeneiAt.65315.

Genome annotation databases

EnsemblPlantsiAT4G01470.1; AT4G01470.1; AT4G01470.
GeneIDi828051.
GrameneiAT4G01470.1; AT4G01470.1; AT4G01470.
KEGGiath:AT4G01470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096370 Genomic DNA. Translation: AAC62778.1.
AL161492 Genomic DNA. Translation: CAB77717.1.
CP002687 Genomic DNA. Translation: AEE82031.1.
DQ446793 mRNA. Translation: ABE66039.1.
DQ653172 mRNA. Translation: ABK28617.1. Sequence problems.
PIRiT01947.
RefSeqiNP_192056.1. NM_116377.2.
UniGeneiAt.65315.

3D structure databases

ProteinModelPortaliO82598.
SMRiO82598.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi13342. 1 interactor.
STRINGi3702.AT4G01470.1.

Protein family/group databases

TCDBi1.A.8.10.6. the major intrinsic protein (mip) family.

Proteomic databases

PaxDbiO82598.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G01470.1; AT4G01470.1; AT4G01470.
GeneIDi828051.
GrameneiAT4G01470.1; AT4G01470.1; AT4G01470.
KEGGiath:AT4G01470.

Organism-specific databases

TAIRiAT4G01470.

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
HOGENOMiHOG000288286.
InParanoidiO82598.
KOiK09873.
OMAiMAYGKLT.
OrthoDBiEOG09360J95.
PhylomeDBiO82598.

Enzyme and pathway databases

ReactomeiR-ATH-1237044. Erythrocytes take up carbon dioxide and release oxygen.
R-ATH-1247673. Erythrocytes take up oxygen and release carbon dioxide.
R-ATH-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-ATH-432047. Passive transport by Aquaporins.

Miscellaneous databases

PROiO82598.

Gene expression databases

GenevisibleiO82598. AT.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIP13_ARATH
AccessioniPrimary (citable) accession number: O82598
Secondary accession number(s): A0MF47, Q1PEC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.