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Protein

Aquaporin TIP1-3

Gene

TIP1-3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential aquaporin, which may facilitate the transport of water and small neutral solutes across cell membranes.By similarity

GO - Molecular functioni

  • urea transmembrane transporter activity Source: TAIR
  • water channel activity Source: TAIR

GO - Biological processi

  • ion transmembrane transport Source: GO_Central
  • urea transport Source: TAIR
  • water transport Source: TAIR

Keywordsi

Biological processStress response, Transport

Enzyme and pathway databases

ReactomeiR-ATH-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-ATH-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-ATH-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-ATH-432047 Passive transport by Aquaporins

Protein family/group databases

TCDBi1.A.8.10.6 the major intrinsic protein (mip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin TIP1-3
Alternative name(s):
Gamma-tonoplast intrinsic protein 3
Short name:
Gamma-TIP3
Tonoplast intrinsic protein 1-3
Short name:
AtTIP1;3
Gene namesi
Name:TIP1-3
Ordered Locus Names:At4g01470
ORF Names:F11O4.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G01470
TAIRilocus:2116987 AT4G01470

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini44 – 55VacuolarSequence analysisAdd BLAST12
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 114CytoplasmicSequence analysisAdd BLAST38
Transmembranei115 – 135Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini136 – 143VacuolarSequence analysis8
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 170CytoplasmicSequence analysis6
Transmembranei171 – 191Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini192 – 219VacuolarSequence analysisAdd BLAST28
Transmembranei220 – 240Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini241 – 252CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640101 – 252Aquaporin TIP1-3Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO82598

Expressioni

Inductioni

By dehydration. Not affected by water stress.

Gene expression databases

ExpressionAtlasiO82598 differential
GenevisibleiO82598 AT

Interactioni

Subunit structurei

Interacts with cucumber mosaic virus (CMV) Protein 1a.1 Publication

Protein-protein interaction databases

BioGridi13342, 1 interactor
STRINGi3702.AT4G01470.1

Structurei

3D structure databases

ProteinModelPortaliO82598
SMRiO82598
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi85 – 87NPA 13
Motifi199 – 201NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
HOGENOMiHOG000288286
InParanoidiO82598
KOiK09873
OMAiRPPYMSS
OrthoDBiEOG09360J95
PhylomeDBiO82598

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequencei

Sequence statusi: Complete.

O82598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPINRIAIGT PGEASRPDAI RAAFAEFFSM VIFVFAGQGS GMAYGKLTGD
60 70 80 90 100
GPATPAGLVA ASLSHAFALF VAVSVGANVS GGHVNPAVTF GAFIGGNITL
110 120 130 140 150
LRAILYWIAQ LLGAVVACLL LKVSTGGMET AAFSLSYGVT PWNAVVFEIV
160 170 180 190 200
MTFGLVYTVY ATAVDPKKGD IGIIAPLAIG LIVGANILVG GAFDGASMNP
210 220 230 240 250
AVSFGPAVVS WIWTNHWVYW VGPFIGAAIA AIVYDTIFIG SNGHEPLPSN

DF
Length:252
Mass (Da):25,914
Last modified:November 1, 1998 - v1
Checksum:iF2FCC1D9DA44A76A
GO

Sequence cautioni

The sequence ABK28617 differs from that shown. Reason: Erroneous termination at position 253. Translated as stop.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096370 Genomic DNA Translation: AAC62778.1
AL161492 Genomic DNA Translation: CAB77717.1
CP002687 Genomic DNA Translation: AEE82031.1
DQ446793 mRNA Translation: ABE66039.1
DQ653172 mRNA Translation: ABK28617.1 Sequence problems.
PIRiT01947
RefSeqiNP_192056.1, NM_116377.2
UniGeneiAt.65315

Genome annotation databases

EnsemblPlantsiAT4G01470.1; AT4G01470.1; AT4G01470
GeneIDi828051
GrameneiAT4G01470.1; AT4G01470.1; AT4G01470
KEGGiath:AT4G01470

Similar proteinsi

Entry informationi

Entry nameiTIP13_ARATH
AccessioniPrimary (citable) accession number: O82598
Secondary accession number(s): A0MF47, Q1PEC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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