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Protein

Adenylate kinase 4

Gene

ADK1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.By similarity

Catalytic activityi

ATP + AMP = 2 ADP.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64AMPBy similarity1
Binding sitei69AMPBy similarity1
Binding sitei125AMPBy similarity1
Binding sitei160ATPBy similarity1
Binding sitei193AMPBy similarity1
Binding sitei204AMPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 48ATPBy similarity6
Nucleotide bindingi90 – 92AMPBy similarity3
Nucleotide bindingi118 – 121AMPBy similarity4

GO - Molecular functioni

  • adenylate kinase activity Source: UniProtKB-EC
  • ATP binding Source: UniProtKB-KW
  • copper ion binding Source: TAIR

GO - Biological processi

  • response to cadmium ion Source: TAIR

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G63400-MONOMER
BRENDAi2.7.4.3 399
ReactomeiR-ATH-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase 4 (EC:2.7.4.3)
Short name:
AK 4
Alternative name(s):
ATP-AMP transphosphorylase 4
ATP:AMP phosphotransferase
Adenylate monophosphate kinase 4
Short name:
AMK4
Gene namesi
Name:ADK1
Ordered Locus Names:At5g63400
ORF Names:MLE2.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G63400
TAIRilocus:2167316 AT5G63400

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001589402 – 246Adenylate kinase 4Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO82514
PRIDEiO82514

PTM databases

iPTMnetiO82514

Expressioni

Gene expression databases

ExpressionAtlasiO82514 baseline and differential
GenevisibleiO82514 AT

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi3702.AT5G63400.1

Structurei

3D structure databases

ProteinModelPortaliO82514
SMRiO82514
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni63 – 92NMPbindBy similarityAdd BLAST30
Regioni159 – 196LIDBy similarityAdd BLAST38

Sequence similaritiesi

Belongs to the adenylate kinase family.Curated

Phylogenomic databases

eggNOGiKOG3078 Eukaryota
COG0563 LUCA
HOGENOMiHOG000238772
KOiK00939
OMAiTIFQRKR
OrthoDBiEOG09360K2G
PhylomeDBiO82514

Family and domain databases

CDDicd01428 ADK, 1 hit
HAMAPiMF_00235 Adenylate_kinase_Adk, 1 hit
InterProiView protein in InterPro
IPR006259 Adenyl_kin_sub
IPR000850 Adenylat/UMP-CMP_kin
IPR033690 Adenylat_kinase_CS
IPR007862 Adenylate_kinase_lid-dom
IPR027417 P-loop_NTPase
PANTHERiPTHR23359 PTHR23359, 1 hit
PfamiView protein in Pfam
PF05191 ADK_lid, 1 hit
PRINTSiPR00094 ADENYLTKNASE
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01351 adk, 1 hit
PROSITEiView protein in PROSITE
PS00113 ADENYLATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: O82514-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATGGAAADL EDVQTVDLMS ELLRRLKCSQ KPDKRLIFIG PPGSGKGTQS
60 70 80 90 100
PVVKDEYCLC HLSTGDMLRA AVASKTPLGV KAKEAMEKGE LVSDDLVVGI
110 120 130 140 150
IDEAMNKPKC QKGFILDGFP RTVTQAEKLD EMLKRRGTEI DKVLNFAIDD
160 170 180 190 200
AILEERITGR WIHPSSGRSY HTKFAPPKTP GVDDITGEPL IQRKDDNADV
210 220 230 240
LKSRLAAFHS QTQPVIDYYA KKAVLTNIQA EKAPQEVTSE VKKALS
Length:246
Mass (Da):26,932
Last modified:November 2, 2001 - v2
Checksum:i659903FBD84B39C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144 – 152LNFAIDDAI → STLLLMTQS in AAC78478 (Ref. 1) Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082882 mRNA Translation: AAC78478.1
AB007649 Genomic DNA Translation: BAB08805.1
CP002688 Genomic DNA Translation: AED97743.1
AY039945 mRNA Translation: AAK64049.1
AY079340 mRNA Translation: AAL85071.1
AY085188 mRNA Translation: AAM61739.1
RefSeqiNP_201145.1, NM_125735.4 [O82514-1]
UniGeneiAt.23458

Genome annotation databases

EnsemblPlantsiAT5G63400.1; AT5G63400.1; AT5G63400 [O82514-1]
GeneIDi836459
GrameneiAT5G63400.1; AT5G63400.1; AT5G63400 [O82514-1]
KEGGiath:AT5G63400

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKAD4_ARATH
AccessioniPrimary (citable) accession number: O82514
Secondary accession number(s): Q9FMW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2001
Last modified: April 25, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome