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Protein

Ethylene-responsive transcription factor CRF1

Gene

CRF1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the cytokinin signaling pathway involved in cotyledons, leaves, and embryos development. Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi86 – 143AP2/ERFPROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • cotyledon development Source: TAIR
  • cytokinin-activated signaling pathway Source: UniProtKB-KW
  • ethylene-activated signaling pathway Source: UniProtKB-KW
  • leaf development Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
  • transcription factor import into nucleus Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cytokinin signaling pathway, Ethylene signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene-responsive transcription factor CRF1
Alternative name(s):
Protein CYTOKININ RESPONSE FACTOR 1
Gene namesi
Name:CRF1
Synonyms:ERF063
Ordered Locus Names:At4g11140
ORF Names:F2P3.5, T22B4.120
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G11140.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002979181 – 287Ethylene-responsive transcription factor CRF1Add BLAST287

Proteomic databases

PaxDbiO82503.

Expressioni

Gene expression databases

GenevisibleiO82503. AT.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRF2Q9SUQ23EBI-5567050,EBI-5567273
CRF3Q9FK123EBI-5567050,EBI-5567993
CRF4Q9SUE34EBI-5567050,EBI-5567027
CRF5O823393EBI-5567050,EBI-5567180

Protein-protein interaction databases

BioGridi12014. 16 interactors.
IntActiO82503. 15 interactors.
STRINGi3702.AT4G11140.1.

Structurei

3D structure databases

ProteinModelPortaliO82503.
SMRiO82503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 AP2/ERF DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IZCZ. Eukaryota.
ENOG410YQNQ. LUCA.
HOGENOMiHOG000237664.
InParanoidiO82503.
OMAiMSESFGG.
OrthoDBiEOG09360QU2.
PhylomeDBiO82503.

Family and domain databases

CDDicd00018. AP2. 1 hit.
Gene3Di3.30.730.10. 1 hit.
InterProiIPR001471. AP2/ERF_dom.
IPR016177. DNA-bd_dom.
[Graphical view]
PfamiPF00847. AP2. 1 hit.
[Graphical view]
PRINTSiPR00367. ETHRSPELEMNT.
SMARTiSM00380. AP2. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS51032. AP2_ERF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O82503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METEKKVSLP RILRISVTDP YATDSSSDEE EEVDFDALST KRRRVKKYVK
60 70 80 90 100
EVVLDSVVSD KEKPMKKKRK KRVVTVPVVV TTATRKFRGV RQRPWGKWAA
110 120 130 140 150
EIRDPSRRVR VWLGTFDTAE EAAIVYDNAA IQLRGPNAEL NFPPPPVTEN
160 170 180 190 200
VEEASTEVKG VSDFIIGGGE CLRSPVSVLE SPFSGESTAV KEEFVGVSTA
210 220 230 240 250
EIVVKKEPSF NGSDFSAPLF SDDDVFGFST SMSESFGGDL FGDNLFADMS
260 270 280
FGSGFGFGSG SGFSSWHVED HFQDIGDLFG SDPVLTV
Length:287
Mass (Da):31,545
Last modified:November 1, 1998 - v1
Checksum:i2EB60595A2F11CF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY560849 mRNA. Translation: AAT44916.1.
AF080120 Genomic DNA. Translation: AAC35537.1.
AL049876 Genomic DNA. Translation: CAB43049.1.
AL161531 Genomic DNA. Translation: CAB81215.1.
CP002687 Genomic DNA. Translation: AEE82977.1.
BT025176 mRNA. Translation: ABE77414.1.
PIRiT01919.
RefSeqiNP_192852.1. NM_117184.4.
UniGeneiAt.33584.

Genome annotation databases

EnsemblPlantsiAT4G11140.1; AT4G11140.1; AT4G11140.
GeneIDi826715.
GrameneiAT4G11140.1; AT4G11140.1; AT4G11140.
KEGGiath:AT4G11140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY560849 mRNA. Translation: AAT44916.1.
AF080120 Genomic DNA. Translation: AAC35537.1.
AL049876 Genomic DNA. Translation: CAB43049.1.
AL161531 Genomic DNA. Translation: CAB81215.1.
CP002687 Genomic DNA. Translation: AEE82977.1.
BT025176 mRNA. Translation: ABE77414.1.
PIRiT01919.
RefSeqiNP_192852.1. NM_117184.4.
UniGeneiAt.33584.

3D structure databases

ProteinModelPortaliO82503.
SMRiO82503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi12014. 16 interactors.
IntActiO82503. 15 interactors.
STRINGi3702.AT4G11140.1.

Proteomic databases

PaxDbiO82503.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G11140.1; AT4G11140.1; AT4G11140.
GeneIDi826715.
GrameneiAT4G11140.1; AT4G11140.1; AT4G11140.
KEGGiath:AT4G11140.

Organism-specific databases

TAIRiAT4G11140.

Phylogenomic databases

eggNOGiENOG410IZCZ. Eukaryota.
ENOG410YQNQ. LUCA.
HOGENOMiHOG000237664.
InParanoidiO82503.
OMAiMSESFGG.
OrthoDBiEOG09360QU2.
PhylomeDBiO82503.

Miscellaneous databases

PROiO82503.

Gene expression databases

GenevisibleiO82503. AT.

Family and domain databases

CDDicd00018. AP2. 1 hit.
Gene3Di3.30.730.10. 1 hit.
InterProiIPR001471. AP2/ERF_dom.
IPR016177. DNA-bd_dom.
[Graphical view]
PfamiPF00847. AP2. 1 hit.
[Graphical view]
PRINTSiPR00367. ETHRSPELEMNT.
SMARTiSM00380. AP2. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS51032. AP2_ERF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRF1_ARATH
AccessioniPrimary (citable) accession number: O82503
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.