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Protein

Translation initiation factor IF-1, chloroplastic

Gene

At4g11175

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-1, chloroplastic
Gene namesi
Ordered Locus Names:At4g11175
ORF Names:F2P3.7, T22B4.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G11175
TAIRilocus:2831681 AT4G11175

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46ChloroplastSequence analysisAdd BLAST46
ChainiPRO_000001446047 – 141Translation initiation factor IF-1, chloroplasticAdd BLAST95

Proteomic databases

PaxDbiO82499
PRIDEiO82499

Expressioni

Gene expression databases

ExpressionAtlasiO82499 baseline and differential
GenevisibleiO82499 AT

Interactioni

Subunit structurei

Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.By similarity

Protein-protein interaction databases

BioGridi12018, 2 interactors
IntActiO82499, 2 interactors
STRINGi3702.AT4G11175.1

Structurei

3D structure databases

ProteinModelPortaliO82499
SMRiO82499
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 138S1-likeAdd BLAST76

Sequence similaritiesi

Belongs to the IF-1 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410J31K Eukaryota
COG0361 LUCA
HOGENOMiHOG000113002
InParanoidiO82499
KOiK02518
OMAiIIFRMSS
OrthoDBiEOG09360TQ6
PhylomeDBiO82499

Family and domain databases

CDDicd04451 S1_IF1, 1 hit
HAMAPiMF_00075 IF_1, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006196 RNA-binding_domain_S1_IF1
IPR022967 S1_dom
IPR004368 TIF_IF1
PANTHERiPTHR33370 PTHR33370, 1 hit
PfamiView protein in Pfam
PF01176 eIF-1a, 1 hit
SMARTiView protein in SMART
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00008 infA, 1 hit
PROSITEiView protein in PROSITE
PS50832 S1_IF1_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O82499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQLCSTFRP QLLLPCQFRF TNGVLIPQIN YVASNSVVNI RPMIRCQRAS
60 70 80 90 100
GGRGGANRSK PAKPQVKEGS NKTVIEGLVT ESLPNGMFRV DLENGDNILG
110 120 130 140
YICGKIRKNF IRILPGDKVK VEMSVYDSTK GRIIFRMSSR D
Length:141
Mass (Da):15,733
Last modified:March 7, 2006 - v2
Checksum:iDC9D1427BE2A3277
GO

Sequence cautioni

The sequence AAC35543 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g11170 has been split into 2 genes: At4g11175 and At4g11170.Curated
The sequence BAD94083 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB43052 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g11170 has been split into 2 genes: At4g11175 and At4g11170.Curated
The sequence CAB81218 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g11170 has been split into 2 genes: At4g11175 and At4g11170.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080120 Genomic DNA Translation: AAC35543.1 Sequence problems.
AL049876 Genomic DNA Translation: CAB43052.1 Sequence problems.
AL161531 Genomic DNA Translation: CAB81218.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE82981.1
BT003712 mRNA Translation: AAO39940.1
AK117848 mRNA Translation: BAC42489.1
AK221313 mRNA Translation: BAD94083.1 Different initiation.
PIRiT01915
T08196
RefSeqiNP_192856.1, NM_117188.5
UniGeneiAt.43672

Genome annotation databases

EnsemblPlantsiAT4G11175.1; AT4G11175.1; AT4G11175
GeneIDi826719
GrameneiAT4G11175.1; AT4G11175.1; AT4G11175
KEGGiath:AT4G11175

Similar proteinsi

Entry informationi

Entry nameiIF1C_ARATH
AccessioniPrimary (citable) accession number: O82499
Secondary accession number(s): Q56YK9, Q8GY59, Q9T016
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 7, 2006
Last modified: April 25, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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