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Protein

Translation initiation factor IF-1, chloroplastic

Gene

At4g11175

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-1, chloroplastic
Gene namesi
Ordered Locus Names:At4g11175
ORF Names:F2P3.7, T22B4.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G11175.
TAIRilocus:2831681. AT4G11175.

Subcellular locationi

GO - Cellular componenti

  • chloroplast Source: TAIR
  • cytosol Source: GO_Central

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46ChloroplastSequence analysisAdd BLAST46
ChainiPRO_000001446047 – 141Translation initiation factor IF-1, chloroplasticAdd BLAST95

Proteomic databases

PaxDbiO82499.
PRIDEiO82499.

Expressioni

Gene expression databases

ExpressionAtlasiO82499. baseline and differential.
GenevisibleiO82499. AT.

Interactioni

Subunit structurei

Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.By similarity

Protein-protein interaction databases

BioGridi12018. 2 interactors.
IntActiO82499. 2 interactors.
STRINGi3702.AT4G11175.1.

Structurei

3D structure databases

ProteinModelPortaliO82499.
SMRiO82499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 138S1-likeAdd BLAST76

Sequence similaritiesi

Belongs to the IF-1 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410J31K. Eukaryota.
COG0361. LUCA.
HOGENOMiHOG000113002.
InParanoidiO82499.
KOiK02518.
OMAiIRCQRAS.
OrthoDBiEOG09360TQ6.
PhylomeDBiO82499.

Family and domain databases

CDDicd04451. S1_IF1. 1 hit.
HAMAPiMF_00075. IF_1. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR022967. S1_dom.
IPR004368. TIF_IF1.
PfamiView protein in Pfam
PF01176. eIF-1a. 1 hit.
SMARTiView protein in SMART
SM00316. S1. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00008. infA. 1 hit.
PROSITEiView protein in PROSITE
PS50832. S1_IF1_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O82499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQLCSTFRP QLLLPCQFRF TNGVLIPQIN YVASNSVVNI RPMIRCQRAS
60 70 80 90 100
GGRGGANRSK PAKPQVKEGS NKTVIEGLVT ESLPNGMFRV DLENGDNILG
110 120 130 140
YICGKIRKNF IRILPGDKVK VEMSVYDSTK GRIIFRMSSR D
Length:141
Mass (Da):15,733
Last modified:March 7, 2006 - v2
Checksum:iDC9D1427BE2A3277
GO

Sequence cautioni

The sequence AAC35543 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g11170 has been split into 2 genes: At4g11175 and At4g11170.Curated
The sequence BAD94083 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB43052 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g11170 has been split into 2 genes: At4g11175 and At4g11170.Curated
The sequence CAB81218 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene At4g11170 has been split into 2 genes: At4g11175 and At4g11170.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080120 Genomic DNA. Translation: AAC35543.1. Sequence problems.
AL049876 Genomic DNA. Translation: CAB43052.1. Sequence problems.
AL161531 Genomic DNA. Translation: CAB81218.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE82981.1.
BT003712 mRNA. Translation: AAO39940.1.
AK117848 mRNA. Translation: BAC42489.1.
AK221313 mRNA. Translation: BAD94083.1. Different initiation.
PIRiT01915.
T08196.
RefSeqiNP_192856.1. NM_117188.5.
UniGeneiAt.43672.

Genome annotation databases

EnsemblPlantsiAT4G11175.1; AT4G11175.1; AT4G11175.
GeneIDi826719.
GrameneiAT4G11175.1; AT4G11175.1; AT4G11175.
KEGGiath:AT4G11175.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIF1C_ARATH
AccessioniPrimary (citable) accession number: O82499
Secondary accession number(s): Q56YK9, Q8GY59, Q9T016
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 7, 2006
Last modified: June 7, 2017
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families