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Protein

Rac-like GTP-binding protein ARAC10

Gene

ARAC10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in local disassembly of cortical microtubules when associated with ICR5.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTPBy similarity
Nucleotide bindingi62 – 665GTPBy similarity
Nucleotide bindingi120 – 1234GTPBy similarity

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • protein kinase binding Source: UniProtKB
  • protein phosphatase binding Source: TAIR

GO - Biological processi

  • negative regulation of abscisic acid-activated signaling pathway Source: TAIR
  • plant-type cell wall organization Source: TAIR
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rac-like GTP-binding protein ARAC10
Alternative name(s):
GTPase protein ROP11
Gene namesi
Name:ARAC10
Synonyms:ROP11
Ordered Locus Names:At5g62880
ORF Names:MQB2.180, MQB2.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G62880.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • cytoskeleton Source: UniProtKB-SubCell
  • nucleus Source: TAIR
  • plasma membrane Source: UniProtKB
  • secondary cell wall Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi202 – 2021C → S: Affects the membrane location. 1 Publication
Mutagenesisi208 – 2081C → S: Affects the membrane location. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Rac-like GTP-binding protein ARAC10PRO_0000198924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi202 – 2021S-palmitoyl cysteine1 Publication
Lipidationi208 – 2081S-palmitoyl cysteine1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiO82481.
PRIDEiO82481.

Expressioni

Gene expression databases

ExpressionAtlasiO82481. baseline and differential.
GenevisibleiO82481. AT.

Interactioni

Subunit structurei

Interacts with ICR5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ROPGEF1Q93ZY24EBI-1548072,EBI-4425188
ROPGEF4Q0WNP74EBI-1548072,EBI-7819454

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein phosphatase binding Source: TAIR

Protein-protein interaction databases

BioGridi21651. 18 interactions.
DIPiDIP-39043N.
IntActiO82481. 16 interactions.
MINTiMINT-8342660.
STRINGi3702.AT5G62880.1.

Structurei

3D structure databases

ProteinModelPortaliO82481.
SMRiO82481. Positions 5-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Effector regionSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi185 – 19713Poly-LysAdd
BLAST

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233974.
InParanoidiO82481.
KOiK04392.
OMAiPEPQKRH.
PhylomeDBiO82481.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O82481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSASKFIK CVTVGDGAVG KTCMLICYTS NKFPTDYIPT VFDNFSANVV
60 70 80 90 100
VEGTTVNLGL WDTAGQEDYN RLRPLSYRGA DVFVLSFSLV SRASYENVFK
110 120 130 140 150
KWIPELQHFA PGVPLVLVGT KLDLREDKHY LADHPGLSPV TTAQGEELRK
160 170 180 190 200
LIGATYYIEC SSKTQQNVKA VFDSAIKEVI KPLVKQKEKT KKKKKQKSNH
210
GCLSNVLCGR IVTRH
Length:215
Mass (Da):23,879
Last modified:November 1, 1998 - v1
Checksum:i02575631F7582E3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079485 mRNA. Translation: AAC63014.1.
AF115467 Genomic DNA. Translation: AAF40238.1.
AB009053 Genomic DNA. Translation: BAB10857.1.
CP002688 Genomic DNA. Translation: AED97667.1.
BT002997 mRNA. Translation: AAO22805.1.
BT004459 mRNA. Translation: AAO42453.1.
PIRiT51824.
RefSeqiNP_201093.1. NM_125682.4.
UniGeneiAt.16939.

Genome annotation databases

EnsemblPlantsiAT5G62880.1; AT5G62880.1; AT5G62880.
GeneIDi836408.
GrameneiAT5G62880.1; AT5G62880.1; AT5G62880.
KEGGiath:AT5G62880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079485 mRNA. Translation: AAC63014.1.
AF115467 Genomic DNA. Translation: AAF40238.1.
AB009053 Genomic DNA. Translation: BAB10857.1.
CP002688 Genomic DNA. Translation: AED97667.1.
BT002997 mRNA. Translation: AAO22805.1.
BT004459 mRNA. Translation: AAO42453.1.
PIRiT51824.
RefSeqiNP_201093.1. NM_125682.4.
UniGeneiAt.16939.

3D structure databases

ProteinModelPortaliO82481.
SMRiO82481. Positions 5-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi21651. 18 interactions.
DIPiDIP-39043N.
IntActiO82481. 16 interactions.
MINTiMINT-8342660.
STRINGi3702.AT5G62880.1.

Proteomic databases

PaxDbiO82481.
PRIDEiO82481.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G62880.1; AT5G62880.1; AT5G62880.
GeneIDi836408.
GrameneiAT5G62880.1; AT5G62880.1; AT5G62880.
KEGGiath:AT5G62880.

Organism-specific databases

TAIRiAT5G62880.

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233974.
InParanoidiO82481.
KOiK04392.
OMAiPEPQKRH.
PhylomeDBiO82481.

Miscellaneous databases

PROiO82481.

Gene expression databases

ExpressionAtlasiO82481. baseline and differential.
GenevisibleiO82481. AT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic structure and evolution of RAC-GTPases in Arabidopsis thaliana."
    Winge P., Brembu T., Kristensen R., Bones A.M.
    Genetics 156:1959-1971(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia and cv. Landsberg erecta.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones."
    Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:41-54(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "A cell-specific, prenylation-independent mechanism regulates targeting of type II RACs."
    Lavy M., Bracha-Drori K., Sternberg H., Yalovsky S.
    Plant Cell 14:2431-2450(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-202 AND CYS-208, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-202 AND CYS-208.
  6. "Initiation of cell wall pattern by a Rho- and microtubule-driven symmetry breaking."
    Oda Y., Fukuda H.
    Science 337:1333-1336(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ICR5, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRAC10_ARATH
AccessioniPrimary (citable) accession number: O82481
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.