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Protein

Ethylene receptor 1

Gene

ETR1

Organism
Cucumis melo var. cantalupensis (Netted muskmelon) (Cucumis melo var. reticulatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Cofactori

Cu cationBy similarityNote: Binds 1 copper ion per dimer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65CopperBy similarity1
Metal bindingi69CopperBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase

Keywords - Biological processi

Ethylene signaling pathway, Two-component regulatory system

Keywords - Ligandi

ATP-binding, Copper, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 1735.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene receptor 1 (EC:2.7.13.3)
Alternative name(s):
Cm-ETR1
MEETR1
Gene namesi
Name:ETR1
OrganismiCucumis melo var. cantalupensis (Netted muskmelon) (Cucumis melo var. reticulatus)
Taxonomic identifieri3658 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeBenincaseaeCucumis

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814141 – 740Ethylene receptor 1Add BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4InterchainBy similarity
Disulfide bondi6InterchainBy similarity
Modified residuei353Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1
Modified residuei6624-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Activation probably requires a transfer of a phosphate group between a His in the transmitter domain and an Asp of the receiver domain.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Expressioni

Tissue specificityi

In seeds and placenta.

Developmental stagei

Early development of fruit and ripening.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Structurei

3D structure databases

ProteinModelPortaliO82436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 307GAFAdd BLAST150
Domaini350 – 588Histidine kinasePROSITE-ProRule annotationAdd BLAST239
Domaini614 – 731Response regulatoryPROSITE-ProRule annotationAdd BLAST118

Sequence similaritiesi

Belongs to the ethylene receptor family.Curated
Contains 1 GAF domain.Curated
Contains 1 histidine kinase domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR014525. ETR.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF026389. Ethyln_sen_HK. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O82436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENCYCIEPQ WPADELLMKY QYISDFFIAL AYFSIPLELI YFVKKSAVFP
60 70 80 90 100
YRWVLVQFGA FIVLCGATHL INLWTFTMHS RTVAVVMTTA KVLTAVVSCA
110 120 130 140 150
TALMLVHIIP DLLSVKTREL FLKNKAAELD REMGLIRTQE ETGRHVRMLT
160 170 180 190 200
HEIRSTLDRH TILKTTLVEL GRTLALEECA LWMPTRTGLE LQLSYTLHQQ
210 220 230 240 250
NPVGYTVPIN LPVISQVFSS NRALKISPNS PVASLRPRAG RYVAGEVVAV
260 270 280 290 300
RVPLLHLSNF QINDWPELST KRYALMVLML PSDSARQWRV HELELVEVVA
310 320 330 340 350
DQVAVALSHA AILEESMRAR DLLMEQNVAL DLARREAETA IRARNDFLAV
360 370 380 390 400
MNHEMRTPMH AIIALSSLLQ ETELTPEQRL MVETILKSSN LLATLINDVL
410 420 430 440 450
DLSRLEDGSL QLDIGTFNLH AVFKEVLNLI KPVTLVKKLS LTLHLGPDLP
460 470 480 490 500
VFAVGDEKRL MQAILNVVGN AVKFSKEGSI SISAIVAKSE TFREIRVPDF
510 520 530 540 550
HPVPSDSHFY LRVQVKDTGS GISPQDIPKL FTKFAQTTVG PRNSGGSGLG
560 570 580 590 600
LAICKRFVNL MEGHIWLESE GLGKGCTATF IVKLGIADQS NESKLPYTSK
610 620 630 640 650
IHENSIHTSF PGLKVLVMDD NGVSRSVTKG LLVHLGCEVT TAGSIEEFLR
660 670 680 690 700
VVSQEHKVVF MDICTPGVDG YELAIRIREK FAKCHERPFM VVLTGNSDKV
710 720 730 740
TKESCLRAGM DGLILKPVSI DKMRSVLSEL IERRVLFETS
Length:740
Mass (Da):82,657
Last modified:November 1, 1998 - v1
Checksum:i7C7D0C56B91C937A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054806 mRNA. Translation: AAC99645.1.
AB052228 mRNA. Translation: BAB18937.1.
PIRiT51619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054806 mRNA. Translation: AAC99645.1.
AB052228 mRNA. Translation: BAB18937.1.
PIRiT51619.

3D structure databases

ProteinModelPortaliO82436.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.13.3. 1735.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR014525. ETR.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF026389. Ethyln_sen_HK. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETR1_CUCMN
AccessioniPrimary (citable) accession number: O82436
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.