ID MDHG2_ARATH Reviewed; 354 AA. AC O82399; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 16-JUN-2009, entry version 78. DE RecName: Full=Probable malate dehydrogenase, glyoxysomal; DE EC=1.1.1.37; DE Flags: Precursor; GN OrderedLocusNames=At2g22780; ORFNames=T30L20.4; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; OC rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX MEDLINE=20083487; PubMed=10617197; DOI=10.1038/45471; RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., RA Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., RA Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., RA Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., RA Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., RA Venter J.C.; RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis RT thaliana."; RL Nature 402:761-768(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX MEDLINE=22954850; PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). CC -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH. CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SUBCELLULAR LOCATION: Glyoxysome (Potential). CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 1 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AC005617; AAC63589.1; -; Genomic_DNA. DR EMBL; AF428346; AAL16276.1; -; mRNA. DR EMBL; BT003009; AAO23574.1; -; mRNA. DR IPI; IPI00523052; -. DR PIR; G84616; G84616. DR RefSeq; NP_179863.1; -. DR UniGene; At.13158; -. DR HSSP; P00346; 1MLD. DR SMR; O82399; 42-353. DR IntAct; O82399; 1. DR PRIDE; O82399; -. DR ProMEX; O82399; -. DR GeneID; 816808; -. DR GenomeReviews; CT485783_GR; AT2G22780. DR KEGG; ath:AT2G22780; -. DR TAIR; At2g22780; -. DR OMA; O82399; KVRLGRC. DR BRENDA; 1.1.1.37; 302. DR ArrayExpress; O82399; -. DR GermOnline; AT2G22780; Arabidopsis thaliana. DR GO; GO:0009507; C:chloroplast; IDA:TAIR. DR GO; GO:0009514; C:glyoxysome; IEA:UniProtKB-SubCell. DR GO; GO:0005777; C:peroxisome; IDA:TAIR. DR GO; GO:0005488; F:binding; IEA:InterPro. DR GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:EC. DR GO; GO:0006096; P:glycolysis; IEA:InterPro. DR GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW. DR GO; GO:0006108; P:malate metabolic process; IEA:InterPro. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR GO; GO:0031998; P:regulation of fatty acid beta-oxidation; IGI:TAIR. DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. DR InterPro; IPR001557; L-lactate/malate_DH. DR InterPro; IPR001236; Lactate/malate_DH. DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C. DR InterPro; IPR001252; Malate_DH_AS. DR InterPro; IPR010097; Malate_DH_NAD-dep_euk_g_bac. DR InterPro; IPR016040; NAD(P)-bd_dom. DR Gene3D; G3DSA:3.90.110.10; lact_mal_DH; 1. DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1. DR PANTHER; PTHR11540:SF1; MDH_euk_g_bac; 1. DR Pfam; PF02866; Ldh_1_C; 1. DR Pfam; PF00056; Ldh_1_N; 1. DR PIRSF; PIRSF000102; Lac_mal_DH; 1. DR TIGRFAMs; TIGR01772; MDH_euk_gproteo; 1. DR PROSITE; PS00068; MDH; 1. PE 1: Evidence at protein level; KW Complete proteome; Glyoxylate bypass; Glyoxysome; NAD; Oxidoreductase; KW Transit peptide; Tricarboxylic acid cycle. FT TRANSIT 1 34 Glyoxysome (Potential). FT CHAIN 35 354 Probable malate dehydrogenase, FT glyoxysomal. FT /FTId=PRO_0000018635. FT NP_BIND 49 55 NAD (By similarity). FT NP_BIND 158 160 NAD (By similarity). FT ACT_SITE 218 218 Proton acceptor (By similarity). FT BINDING 75 75 NAD (By similarity). FT BINDING 122 122 Substrate (By similarity). FT BINDING 128 128 Substrate (By similarity). FT BINDING 135 135 NAD (By similarity). FT BINDING 160 160 Substrate (By similarity). FT BINDING 194 194 Substrate (By similarity). FT BINDING 269 269 NAD (By similarity). SQ SEQUENCE 354 AA; 37466 MW; 715CDC22B4448629 CRC64; MDPNQRIARI SAHLNPPNLH NQIADGSGLN RVACRAKGGS PGFKVAILGA AGGIGQPLAM LMKMNPLVSV LHLYDVANAP GVTADISHMD TSAVVRGFLG QPQLEEALTG MDLVIIPAGV PRKPGMTRDD LFNINAGIVR TLSEAIAKCC PKAIVNIISN PVNSTVPIAA EVFKKAGTFD PKKLMGVTML DVVRANTFVA EVMSLDPREV EVPVVGGHAG VTILPLLSQV KPPCSFTQKE IEYLTDRIQN GGTEVVEAKA GAGSATLSMA YAAVEFADAC LRGLRGDANI VECAYVASHV TELPFFASKV RLGRCGIDEV YGLGPLNEYE RMGLEKAKKE LSVSIHKGVT FAKK //