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Protein

Josephin-like protein

Gene

At2g29640

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a deubiquitinating enzyme.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei18NucleophilePROSITE-ProRule annotation1
Active sitei129Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease
Biological processUbl conjugation pathway
LigandNucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-5689877 Josephin domain DUBs

Protein family/group databases

MEROPSiC86.A02

Names & Taxonomyi

Protein namesi
Recommended name:
Josephin-like protein (EC:3.4.19.12)
Gene namesi
Ordered Locus Names:At2g29640
ORF Names:T27A16.26
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G29640
TAIRilocus:2060704 AT2G29640

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538461 – 360Josephin-like proteinAdd BLAST360

Proteomic databases

PaxDbiO82391

Expressioni

Gene expression databases

ExpressionAtlasiO82391 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G29640.1

Structurei

3D structure databases

ProteinModelPortaliO82391
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 192JosephinPROSITE-ProRule annotationAdd BLAST188

Phylogenomic databases

eggNOGiKOG2934 Eukaryota
ENOG4111I4J LUCA
HOGENOMiHOG000113135
InParanoidiO82391
KOiK15235
OMAiGPYYKNP
OrthoDBiEOG09360K1H
PhylomeDBiO82391

Family and domain databases

InterProiView protein in InterPro
IPR006155 Josephin
PfamiView protein in Pfam
PF02099 Josephin, 1 hit
SMARTiView protein in SMART
SM01246 Josephin, 1 hit
PROSITEiView protein in PROSITE
PS50957 JOSEPHIN, 1 hit

Sequencei

Sequence statusi: Complete.

O82391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSESKIYH ERQRLQFCLL HCLNNLFQDK DAFTKESLNS IAEKLETNDP
60 70 80 90 100
NKETWTPLSF VLKPHHNTIT GNYDVNVMIT ALEGKGKSVV WHDKRIGASS
110 120 130 140 150
IDLDDADTLM GIVLNVPVKR YGGLWRSRHW VVVRKINGVW YNLDSDLVVP
160 170 180 190 200
QLFRDDDEVR GFLDQNLSLD VIGLIWNLPY NANQLPLASN YRVVITHWSD
210 220 230 240 250
LNGMFSHVTN YPLDFDVYPQ VSSKVSAIYK ATGTKRFNAN TRPVTPGKQS
260 270 280 290 300
SVKGPYYKNP GCTTSCGLRL PRKTECTAAR LIKDLSCKFV MGLRLVVMRK
310 320 330 340 350
KKKKRSPPLK KASSSGISQP SVISVVNDNN HRSAAIEDCI QFINSSSSFT
360
RSNSTCGSKS
Length:360
Mass (Da):40,489
Last modified:November 1, 1998 - v1
Checksum:i01701E35AB2C981D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005496 Genomic DNA Translation: AAC35231.1
CP002685 Genomic DNA Translation: AEC08284.1
PIRiG84698
RefSeqiNP_180525.1, NM_128518.2
UniGeneiAt.52967

Genome annotation databases

EnsemblPlantsiAT2G29640.1; AT2G29640.1; AT2G29640
GeneIDi817514
GrameneiAT2G29640.1; AT2G29640.1; AT2G29640
KEGGiath:AT2G29640

Similar proteinsi

Entry informationi

Entry nameiJOSL_ARATH
AccessioniPrimary (citable) accession number: O82391
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health