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Protein

Protein SLOW WALKER 1

Gene

SWA1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Essential protein required for nuclear division and organization during embryo sac development in female gametophyte, probably by promoting rRNA biogenesis essential for the progression of the mitotic division cycles during gametogenesis (PubMed:15634699, PubMed:15980260). Involved in nucleolar processing of pre-18S ribosomal RNA (PubMed:15980260).2 Publications

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • embryo sac development Source: TAIR
  • megagametogenesis Source: TAIR
  • rRNA processing Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell cycle, Cell division, rRNA processing

Enzyme and pathway databases

ReactomeiR-ATH-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SLOW WALKER 11 Publication
Alternative name(s):
Protein EMBRYO SAC DEVELOPMENT ARREST 131 Publication
Protein EMBRYO SAC DEVELOPMENT ARREST 191 Publication
Gene namesi
Name:SWA11 Publication
Synonyms:EDA131 Publication, EDA191 Publication
Ordered Locus Names:At2g47990Imported
ORF Names:F17A22Imported, T9J23.30Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G47990.

Subcellular locationi

  • Nucleusnucleolus 1 Publication

  • Note: Localized in the nucleolus in interphase cells.1 Publication

GO - Cellular componenti

  • Cul4-RING E3 ubiquitin ligase complex Source: TAIR
  • nucleolus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryo sac development arrest at two-, four-, or eight-nucleate stages, associated with abnormal nuclear numbers and positions in embryo sac, aberrant embryo sacs and unfused polar nuclei (PubMed:15634699). Disrupted progression of the mitotic division cycles of the female gametophyte leading to an impaired synchrony of female gametophyte development (PubMed:15980260). Reduced root growth and accumulation of unprocessed 18S pre-rRNA (PubMed:15980260).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004326521 – 530Protein SLOW WALKER 1Add BLAST530

Proteomic databases

PaxDbiO82266.

Expressioni

Tissue specificityi

Expressed in cells undergoing active cell divisions, including functional megaspores and the female gametophytic cells. Accumulates in roots, stems, leaves, inflorescences and siliques.1 Publication

Developmental stagei

Accumulates in root tips and lateral root primordia. Present in young leaf and stem vascular tissues. Expressed throughout pollen development from very young floral buds to dehisced anthers, especially in microsporogenous cells, microspores, and mature pollen grains. In female reproductive organs, detected in megaspores and embryo sacs from one-nucleate to seven-celled embryo sacs.1 Publication

Gene expression databases

GenevisibleiO82266. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G47990.1.

Structurei

3D structure databases

ProteinModelPortaliO82266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati50 – 89WD 1Sequence analysisAdd BLAST40
Repeati91 – 130WD 2Sequence analysisAdd BLAST40
Repeati133 – 173WD 3Sequence analysisAdd BLAST41
Repeati176 – 216WD 4Sequence analysisAdd BLAST41
Repeati220 – 258WD 5Sequence analysisAdd BLAST39
Repeati262 – 304WD 6Sequence analysisAdd BLAST43
Repeati320 – 363WD 7Sequence analysisAdd BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi392 – 399Nuclear localization signalPROSITE-ProRule annotation8

Sequence similaritiesi

Contains 7 WD repeats.Sequence analysis

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0310. Eukaryota.
ENOG410XNZ0. LUCA.
HOGENOMiHOG000185028.
KOiK14549.
OMAiDILINRP.
OrthoDBiEOG093608FR.
PhylomeDBiO82266.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF09384. UTP15_C. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O82266-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEELRVRLN DHQVSKVFPV KPKSTAKPVS ESETPESRYW SSFKNHSTPN
60 70 80 90 100
LVSSVAALAF SPVHPHSLAV AHSATVSLFS SQSLSSSRRF SFRDVVSSVC
110 120 130 140 150
FRSDGALFAA CDLSGVVQVF DIKERMALRT LRSHSAPARF VKYPVQDKLH
160 170 180 190 200
LVSGGDDGVV KYWDVAGATV ISDLLGHKDY VRCGDCSPVN DSMLVTGSYD
210 220 230 240 250
HTVKVWDARV HTSNWIAEIN HGLPVEDVVY LPSGGLIATA GGNSVKVWDL
260 270 280 290 300
IGGGKMVCSM ESHNKTVTSL RVARMESAES RLVSVALDGY MKVFDYGRAK
310 320 330 340 350
VTYSMRFPAP LMSLGLSPDG STRVIGGSNG MVFAGKKKVR DVVGGQKKSL
360 370 380 390 400
NLWSLISDVD ESRRRALRPT YFRYFQRGQS EKPSKDDYLV KEKKGLKLTR
410 420 430 440 450
HDKLLKKFRH KEALVSVLEE KKPANVVAVM EELVARRKLM KCVSNMEEGE
460 470 480 490 500
LGMLLGFLQR YCTVQRYSGL LMGLTKKVLE TRAEDIKGKN EFKGLLRNLK
510 520 530
REVNQEIRIQ QSLLEIQGVI APLMRIAGRS
Length:530
Mass (Da):58,903
Last modified:November 1, 1998 - v1
Checksum:i6F1B4AB984F3162B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188P → S in BAC42762 (PubMed:11910074).Curated1
Sequence conflicti382K → E in BAC42762 (PubMed:11910074).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005309 Genomic DNA. Translation: AAC63653.1.
AC006072 Genomic DNA. Translation: AAM15129.1.
CP002685 Genomic DNA. Translation: AEC10921.1.
AK118137 mRNA. Translation: BAC42762.1.
PIRiA84922.
RefSeqiNP_182320.1. NM_130366.3.
UniGeneiAt.436.
At.71162.

Genome annotation databases

EnsemblPlantsiAT2G47990.1; AT2G47990.1; AT2G47990.
GeneIDi819411.
GrameneiAT2G47990.1; AT2G47990.1; AT2G47990.
KEGGiath:AT2G47990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005309 Genomic DNA. Translation: AAC63653.1.
AC006072 Genomic DNA. Translation: AAM15129.1.
CP002685 Genomic DNA. Translation: AEC10921.1.
AK118137 mRNA. Translation: BAC42762.1.
PIRiA84922.
RefSeqiNP_182320.1. NM_130366.3.
UniGeneiAt.436.
At.71162.

3D structure databases

ProteinModelPortaliO82266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G47990.1.

Proteomic databases

PaxDbiO82266.

Protocols and materials databases

DNASUi819411.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G47990.1; AT2G47990.1; AT2G47990.
GeneIDi819411.
GrameneiAT2G47990.1; AT2G47990.1; AT2G47990.
KEGGiath:AT2G47990.

Organism-specific databases

TAIRiAT2G47990.

Phylogenomic databases

eggNOGiKOG0310. Eukaryota.
ENOG410XNZ0. LUCA.
HOGENOMiHOG000185028.
KOiK14549.
OMAiDILINRP.
OrthoDBiEOG093608FR.
PhylomeDBiO82266.

Enzyme and pathway databases

ReactomeiR-ATH-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiO82266.

Gene expression databases

GenevisibleiO82266. AT.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF09384. UTP15_C. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSWA1_ARATH
AccessioniPrimary (citable) accession number: O82266
Secondary accession number(s): Q8GXN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.