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Protein

Protein SLOW WALKER 1

Gene

SWA1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential protein required for nuclear division and organization during embryo sac development in female gametophyte, probably by promoting rRNA biogenesis essential for the progression of the mitotic division cycles during gametogenesis (PubMed:15634699, PubMed:15980260). Involved in nucleolar processing of pre-18S ribosomal RNA (PubMed:15980260).2 Publications

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • embryo sac development Source: TAIR
  • megagametogenesis Source: TAIR
  • rRNA processing Source: TAIR

Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle, Cell division, rRNA processing

Enzyme and pathway databases

ReactomeiR-ATH-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SLOW WALKER 11 Publication
Alternative name(s):
Protein EMBRYO SAC DEVELOPMENT ARREST 131 Publication
Protein EMBRYO SAC DEVELOPMENT ARREST 191 Publication
Gene namesi
Name:SWA11 Publication
Synonyms:EDA131 Publication, EDA191 Publication
Ordered Locus Names:At2g47990Imported
ORF Names:F17A22Imported, T9J23.30Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G47990
TAIRilocus:2043333 AT2G47990

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryo sac development arrest at two-, four-, or eight-nucleate stages, associated with abnormal nuclear numbers and positions in embryo sac, aberrant embryo sacs and unfused polar nuclei (PubMed:15634699). Disrupted progression of the mitotic division cycles of the female gametophyte leading to an impaired synchrony of female gametophyte development (PubMed:15980260). Reduced root growth and accumulation of unprocessed 18S pre-rRNA (PubMed:15980260).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004326521 – 530Protein SLOW WALKER 1Add BLAST530

Proteomic databases

PaxDbiO82266

Expressioni

Tissue specificityi

Expressed in cells undergoing active cell divisions, including functional megaspores and the female gametophytic cells. Accumulates in roots, stems, leaves, inflorescences and siliques.1 Publication

Developmental stagei

Accumulates in root tips and lateral root primordia. Present in young leaf and stem vascular tissues. Expressed throughout pollen development from very young floral buds to dehisced anthers, especially in microsporogenous cells, microspores, and mature pollen grains. In female reproductive organs, detected in megaspores and embryo sacs from one-nucleate to seven-celled embryo sacs.1 Publication

Gene expression databases

ExpressionAtlasiO82266 baseline and differential
GenevisibleiO82266 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G47990.1

Structurei

3D structure databases

ProteinModelPortaliO82266
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati50 – 89WD 1Sequence analysisAdd BLAST40
Repeati91 – 130WD 2Sequence analysisAdd BLAST40
Repeati133 – 173WD 3Sequence analysisAdd BLAST41
Repeati176 – 216WD 4Sequence analysisAdd BLAST41
Repeati220 – 258WD 5Sequence analysisAdd BLAST39
Repeati262 – 304WD 6Sequence analysisAdd BLAST43
Repeati320 – 363WD 7Sequence analysisAdd BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi392 – 399Nuclear localization signalPROSITE-ProRule annotation8

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0310 Eukaryota
ENOG410XNZ0 LUCA
HOGENOMiHOG000185028
KOiK14549
OMAiRFKDTAY
OrthoDBiEOG093608FR
PhylomeDBiO82266

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR018983 U3_snoRNA-assocProt_15_C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF09384 UTP15_C, 1 hit
PF00400 WD40, 2 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O82266-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEELRVRLN DHQVSKVFPV KPKSTAKPVS ESETPESRYW SSFKNHSTPN
60 70 80 90 100
LVSSVAALAF SPVHPHSLAV AHSATVSLFS SQSLSSSRRF SFRDVVSSVC
110 120 130 140 150
FRSDGALFAA CDLSGVVQVF DIKERMALRT LRSHSAPARF VKYPVQDKLH
160 170 180 190 200
LVSGGDDGVV KYWDVAGATV ISDLLGHKDY VRCGDCSPVN DSMLVTGSYD
210 220 230 240 250
HTVKVWDARV HTSNWIAEIN HGLPVEDVVY LPSGGLIATA GGNSVKVWDL
260 270 280 290 300
IGGGKMVCSM ESHNKTVTSL RVARMESAES RLVSVALDGY MKVFDYGRAK
310 320 330 340 350
VTYSMRFPAP LMSLGLSPDG STRVIGGSNG MVFAGKKKVR DVVGGQKKSL
360 370 380 390 400
NLWSLISDVD ESRRRALRPT YFRYFQRGQS EKPSKDDYLV KEKKGLKLTR
410 420 430 440 450
HDKLLKKFRH KEALVSVLEE KKPANVVAVM EELVARRKLM KCVSNMEEGE
460 470 480 490 500
LGMLLGFLQR YCTVQRYSGL LMGLTKKVLE TRAEDIKGKN EFKGLLRNLK
510 520 530
REVNQEIRIQ QSLLEIQGVI APLMRIAGRS
Length:530
Mass (Da):58,903
Last modified:November 1, 1998 - v1
Checksum:i6F1B4AB984F3162B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188P → S in BAC42762 (PubMed:11910074).Curated1
Sequence conflicti382K → E in BAC42762 (PubMed:11910074).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005309 Genomic DNA Translation: AAC63653.1
AC006072 Genomic DNA Translation: AAM15129.1
CP002685 Genomic DNA Translation: AEC10921.1
AK118137 mRNA Translation: BAC42762.1
PIRiA84922
RefSeqiNP_182320.1, NM_130366.3
UniGeneiAt.436
At.71162

Genome annotation databases

EnsemblPlantsiAT2G47990.1; AT2G47990.1; AT2G47990
GeneIDi819411
GrameneiAT2G47990.1; AT2G47990.1; AT2G47990
KEGGiath:AT2G47990

Similar proteinsi

Entry informationi

Entry nameiSWA1_ARATH
AccessioniPrimary (citable) accession number: O82266
Secondary accession number(s): Q8GXN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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