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Protein

Probable cyclic nucleotide-gated ion channel 6

Gene

CNGC6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable cyclic nucleotide-gated ion channel.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei585cNMPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi514 – 638cNMPAdd BLAST125

GO - Molecular functioni

GO - Biological processi

  • regulation of membrane potential Source: GO_Central
  • response to cadmium ion Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calmodulin-binding, cAMP, cAMP-binding, cGMP, cGMP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-2485179. Activation of the phototransduction cascade.
R-ATH-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-ATH-5620916. VxPx cargo-targeting to cilium.

Protein family/group databases

TCDBi1.A.1.5.14. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cyclic nucleotide-gated ion channel 6
Short name:
AtCNGC6
Alternative name(s):
Cyclic nucleotide- and calmodulin-regulated ion channel 6
Gene namesi
Name:CNGC6
Ordered Locus Names:At2g23980
ORF Names:T29E15.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G23980.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 117CytoplasmicSequence analysisAdd BLAST117
Transmembranei118 – 138Helical; Name=H1Sequence analysisAdd BLAST21
Topological domaini139 – 150ExtracellularSequence analysisAdd BLAST12
Transmembranei151 – 171Helical; Name=H2Sequence analysisAdd BLAST21
Topological domaini172 – 205CytoplasmicSequence analysisAdd BLAST34
Transmembranei206 – 226Helical; Name=H3Sequence analysisAdd BLAST21
Topological domaini227 – 239ExtracellularSequence analysisAdd BLAST13
Transmembranei240 – 260Helical; Name=H4Sequence analysisAdd BLAST21
Topological domaini261 – 280CytoplasmicSequence analysisAdd BLAST20
Transmembranei281 – 301Helical; Name=H5Sequence analysisAdd BLAST21
Topological domaini302 – 407ExtracellularSequence analysisAdd BLAST106
Transmembranei408 – 428Helical; Name=H6Sequence analysisAdd BLAST21
Topological domaini429 – 747CytoplasmicSequence analysisAdd BLAST319

GO - Cellular componenti

  • cell periphery Source: TAIR
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193341 – 747Probable cyclic nucleotide-gated ion channel 6Add BLAST747

Proteomic databases

PaxDbiO82226.
PRIDEiO82226.

PTM databases

iPTMnetiO82226.

Expressioni

Gene expression databases

GenevisibleiO82226. AT.

Interactioni

Subunit structurei

Homotetramer or heterotetramer.Curated

Protein-protein interaction databases

BioGridi2283. 17 interactors.
MINTiMINT-8059780.
STRINGi3702.AT2G23980.1.

Structurei

Secondary structure

1747
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi514 – 516Combined sources3
Helixi520 – 529Combined sources10
Beta strandi539 – 542Combined sources4
Beta strandi549 – 556Combined sources8
Beta strandi560 – 562Combined sources3
Beta strandi568 – 572Combined sources5
Beta strandi574 – 576Combined sources3
Beta strandi582 – 584Combined sources3
Helixi586 – 592Combined sources7
Beta strandi598 – 600Combined sources3
Beta strandi604 – 611Combined sources8
Beta strandi613 – 619Combined sources7
Helixi620 – 630Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGPNMR-A509-632[»]
ProteinModelPortaliO82226.
SMRiO82226.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO82226.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini650 – 679IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni630 – 645Calmodulin-bindingBy similarityAdd BLAST16

Domaini

The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation.By similarity

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 IQ domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000238338.
InParanoidiO82226.
KOiK05391.
OMAiTKELVKF.
OrthoDBiEOG093603N1.
PhylomeDBiO82226.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O82226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDTCGPKGV KSQVISGQRE NFVRLDSMDS RYSQSSETGL NKCTLNIQGG
60 70 80 90 100
PKRFAQGSKA SSGSFKKGFR KGSEGLWSIG RSIGLGVSRA VFPEDLEVSE
110 120 130 140 150
KKIFDPQDKF LLLCNKLFVA SCILAVSVDP LFLYLPFIND KAKCVGIDRK
160 170 180 190 200
LAIIVTTIRT VIDSFYLFHM ALRFRTAYVA PSSRVFGRGE LVIDPAQIAK
210 220 230 240 250
RYLQQYFIID LLSVLPVPQI IVWRFLYTSR GANVLATKQA LRYIVLVQYI
260 270 280 290 300
PRFLRMYPLS SELKRTAGVF AETAWAGAAY YLLLYMLASH IVGALWYLLA
310 320 330 340 350
LERNNDCWSK ACHNNQNCTR NFLFCGNQNM KGYAAWDNIK VSYLQLKCPV
360 370 380 390 400
NVPEDEEPPF DFGIYLRALS SGIVSSKNFV SKYFFCLWWG LQNLSTLGQG
410 420 430 440 450
LETSTYPGEV IFSITLAIAG LLLFALLIGN MQTYLQSLTI RLEEMRVKRR
460 470 480 490 500
DSEQWMHHRM LPPELRERVR RYDQYKWLET RGVDEENLVQ NLPKDLRRDI
510 520 530 540 550
KRHLCLALVR RVPLFENMDE RLLDAICERL KPCLFTEKSY LVREGDPVNE
560 570 580 590 600
MLFIIRGRLE SVTTDGGRSG FYNRSLLKEG DFCGDELLTW ALDPKSGSNL
610 620 630 640 650
PSSTRTVKAL TEVEAFALIA DELKFVASQF RRLHSRQVQH TFRFYSQQWR
660 670 680 690 700
TWAACFMQAA WRRYIKRKKL EQLRKEEEEE EAAAASVIAG GSPYSIRATF
710 720 730 740
LASKFAANAL RSVHKNRTAK STLLLSSTKE LVKFQKPPEP DFSAEDH
Length:747
Mass (Da):85,441
Last modified:June 1, 2002 - v2
Checksum:i601234797E44700F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17914 mRNA. Translation: CAB40131.1.
AC005170 Genomic DNA. Translation: AAC63666.2.
CP002685 Genomic DNA. Translation: AEC07510.1.
PIRiB84631.
T52572.
RefSeqiNP_565560.1. NM_127960.3.
UniGeneiAt.402.

Genome annotation databases

EnsemblPlantsiAT2G23980.1; AT2G23980.1; AT2G23980.
GeneIDi816931.
GrameneiAT2G23980.1; AT2G23980.1; AT2G23980.
KEGGiath:AT2G23980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17914 mRNA. Translation: CAB40131.1.
AC005170 Genomic DNA. Translation: AAC63666.2.
CP002685 Genomic DNA. Translation: AEC07510.1.
PIRiB84631.
T52572.
RefSeqiNP_565560.1. NM_127960.3.
UniGeneiAt.402.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGPNMR-A509-632[»]
ProteinModelPortaliO82226.
SMRiO82226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2283. 17 interactors.
MINTiMINT-8059780.
STRINGi3702.AT2G23980.1.

Protein family/group databases

TCDBi1.A.1.5.14. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiO82226.

Proteomic databases

PaxDbiO82226.
PRIDEiO82226.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G23980.1; AT2G23980.1; AT2G23980.
GeneIDi816931.
GrameneiAT2G23980.1; AT2G23980.1; AT2G23980.
KEGGiath:AT2G23980.

Organism-specific databases

TAIRiAT2G23980.

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000238338.
InParanoidiO82226.
KOiK05391.
OMAiTKELVKF.
OrthoDBiEOG093603N1.
PhylomeDBiO82226.

Enzyme and pathway databases

ReactomeiR-ATH-2485179. Activation of the phototransduction cascade.
R-ATH-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-ATH-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

EvolutionaryTraceiO82226.
PROiO82226.

Gene expression databases

GenevisibleiO82226. AT.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNGC6_ARATH
AccessioniPrimary (citable) accession number: O82226
Secondary accession number(s): Q9XFS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.