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Protein

Probable cyclic nucleotide-gated ion channel 6

Gene

CNGC6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable cyclic nucleotide-gated ion channel.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei585 – 5851cNMPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi514 – 638125cNMPAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cation transmembrane transport Source: GOC
  • potassium ion transmembrane transport Source: GOC
  • regulation of membrane potential Source: GO_Central
  • response to cadmium ion Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calmodulin-binding, cAMP, cAMP-binding, cGMP, cGMP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-2485179. Activation of the phototransduction cascade.
R-ATH-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-ATH-5620916. VxPx cargo-targeting to cilium.

Protein family/group databases

TCDBi1.A.1.5.14. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cyclic nucleotide-gated ion channel 6
Short name:
AtCNGC6
Alternative name(s):
Cyclic nucleotide- and calmodulin-regulated ion channel 6
Gene namesi
Name:CNGC6
Ordered Locus Names:At2g23980
ORF Names:T29E15.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G23980.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 117117CytoplasmicSequence analysisAdd
BLAST
Transmembranei118 – 13821Helical; Name=H1Sequence analysisAdd
BLAST
Topological domaini139 – 15012ExtracellularSequence analysisAdd
BLAST
Transmembranei151 – 17121Helical; Name=H2Sequence analysisAdd
BLAST
Topological domaini172 – 20534CytoplasmicSequence analysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=H3Sequence analysisAdd
BLAST
Topological domaini227 – 23913ExtracellularSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=H4Sequence analysisAdd
BLAST
Topological domaini261 – 28020CytoplasmicSequence analysisAdd
BLAST
Transmembranei281 – 30121Helical; Name=H5Sequence analysisAdd
BLAST
Topological domaini302 – 407106ExtracellularSequence analysisAdd
BLAST
Transmembranei408 – 42821Helical; Name=H6Sequence analysisAdd
BLAST
Topological domaini429 – 747319CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell periphery Source: TAIR
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747Probable cyclic nucleotide-gated ion channel 6PRO_0000219334Add
BLAST

Proteomic databases

PaxDbiO82226.
PRIDEiO82226.

Expressioni

Gene expression databases

GenevisibleiO82226. AT.

Interactioni

Subunit structurei

Homotetramer or heterotetramer.Curated

Protein-protein interaction databases

BioGridi2283. 17 interactions.
MINTiMINT-8059780.
STRINGi3702.AT2G23980.1.

Structurei

Secondary structure

1
747
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi514 – 5163Combined sources
Helixi520 – 52910Combined sources
Beta strandi539 – 5424Combined sources
Beta strandi549 – 5568Combined sources
Beta strandi560 – 5623Combined sources
Beta strandi568 – 5725Combined sources
Beta strandi574 – 5763Combined sources
Beta strandi582 – 5843Combined sources
Helixi586 – 5927Combined sources
Beta strandi598 – 6003Combined sources
Beta strandi604 – 6118Combined sources
Beta strandi613 – 6197Combined sources
Helixi620 – 63011Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WGPNMR-A509-632[»]
ProteinModelPortaliO82226.
SMRiO82226. Positions 448-632.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO82226.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini650 – 67930IQPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni630 – 64516Calmodulin-bindingBy similarityAdd
BLAST

Domaini

The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation.By similarity

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 IQ domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000238338.
InParanoidiO82226.
KOiK05391.
OMAiTKELVKF.
PhylomeDBiO82226.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O82226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDTCGPKGV KSQVISGQRE NFVRLDSMDS RYSQSSETGL NKCTLNIQGG
60 70 80 90 100
PKRFAQGSKA SSGSFKKGFR KGSEGLWSIG RSIGLGVSRA VFPEDLEVSE
110 120 130 140 150
KKIFDPQDKF LLLCNKLFVA SCILAVSVDP LFLYLPFIND KAKCVGIDRK
160 170 180 190 200
LAIIVTTIRT VIDSFYLFHM ALRFRTAYVA PSSRVFGRGE LVIDPAQIAK
210 220 230 240 250
RYLQQYFIID LLSVLPVPQI IVWRFLYTSR GANVLATKQA LRYIVLVQYI
260 270 280 290 300
PRFLRMYPLS SELKRTAGVF AETAWAGAAY YLLLYMLASH IVGALWYLLA
310 320 330 340 350
LERNNDCWSK ACHNNQNCTR NFLFCGNQNM KGYAAWDNIK VSYLQLKCPV
360 370 380 390 400
NVPEDEEPPF DFGIYLRALS SGIVSSKNFV SKYFFCLWWG LQNLSTLGQG
410 420 430 440 450
LETSTYPGEV IFSITLAIAG LLLFALLIGN MQTYLQSLTI RLEEMRVKRR
460 470 480 490 500
DSEQWMHHRM LPPELRERVR RYDQYKWLET RGVDEENLVQ NLPKDLRRDI
510 520 530 540 550
KRHLCLALVR RVPLFENMDE RLLDAICERL KPCLFTEKSY LVREGDPVNE
560 570 580 590 600
MLFIIRGRLE SVTTDGGRSG FYNRSLLKEG DFCGDELLTW ALDPKSGSNL
610 620 630 640 650
PSSTRTVKAL TEVEAFALIA DELKFVASQF RRLHSRQVQH TFRFYSQQWR
660 670 680 690 700
TWAACFMQAA WRRYIKRKKL EQLRKEEEEE EAAAASVIAG GSPYSIRATF
710 720 730 740
LASKFAANAL RSVHKNRTAK STLLLSSTKE LVKFQKPPEP DFSAEDH
Length:747
Mass (Da):85,441
Last modified:June 1, 2002 - v2
Checksum:i601234797E44700F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17914 mRNA. Translation: CAB40131.1.
AC005170 Genomic DNA. Translation: AAC63666.2.
CP002685 Genomic DNA. Translation: AEC07510.1.
PIRiB84631.
T52572.
RefSeqiNP_565560.1. NM_127960.3.
UniGeneiAt.402.

Genome annotation databases

EnsemblPlantsiAT2G23980.1; AT2G23980.1; AT2G23980.
GeneIDi816931.
GrameneiAT2G23980.1; AT2G23980.1; AT2G23980.
KEGGiath:AT2G23980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17914 mRNA. Translation: CAB40131.1.
AC005170 Genomic DNA. Translation: AAC63666.2.
CP002685 Genomic DNA. Translation: AEC07510.1.
PIRiB84631.
T52572.
RefSeqiNP_565560.1. NM_127960.3.
UniGeneiAt.402.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WGPNMR-A509-632[»]
ProteinModelPortaliO82226.
SMRiO82226. Positions 448-632.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2283. 17 interactions.
MINTiMINT-8059780.
STRINGi3702.AT2G23980.1.

Protein family/group databases

TCDBi1.A.1.5.14. the voltage-gated ion channel (vic) superfamily.

Proteomic databases

PaxDbiO82226.
PRIDEiO82226.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G23980.1; AT2G23980.1; AT2G23980.
GeneIDi816931.
GrameneiAT2G23980.1; AT2G23980.1; AT2G23980.
KEGGiath:AT2G23980.

Organism-specific databases

TAIRiAT2G23980.

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000238338.
InParanoidiO82226.
KOiK05391.
OMAiTKELVKF.
PhylomeDBiO82226.

Enzyme and pathway databases

ReactomeiR-ATH-2485179. Activation of the phototransduction cascade.
R-ATH-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-ATH-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

EvolutionaryTraceiO82226.
PROiO82226.

Gene expression databases

GenevisibleiO82226. AT.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterisation of a novel gene family of putative cyclic nucleotide- and calmodulin-regulated ion channels in Arabidopsis thaliana."
    Koehler C., Merkle T., Neuhaus G.
    Plant J. 18:97-104(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Cited for: GENE FAMILY, NOMENCLATURE.
  5. "Solution structure of the cnmp-binding domain from Arabidopsis thaliana cyclic nucleotide-regulated ion channel."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 509-632.

Entry informationi

Entry nameiCNGC6_ARATH
AccessioniPrimary (citable) accession number: O82226
Secondary accession number(s): Q9XFS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2002
Last modified: February 17, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.