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Protein

Probable cyclic nucleotide-gated ion channel 6

Gene

CNGC6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable cyclic nucleotide-gated ion channel.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei585cNMPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi514 – 638cNMPAdd BLAST125

GO - Molecular functioni

GO - Biological processi

  • regulation of membrane potential Source: GO_Central
  • response to cadmium ion Source: TAIR

Keywordsi

Molecular functionCalmodulin-binding, Ion channel, Ligand-gated ion channel
Biological processIon transport, Transport
LigandcAMP, cAMP-binding, cGMP, cGMP-binding, Nucleotide-binding

Protein family/group databases

TCDBi1.A.1.5.14 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cyclic nucleotide-gated ion channel 6
Short name:
AtCNGC6
Alternative name(s):
Cyclic nucleotide- and calmodulin-regulated ion channel 6
Gene namesi
Name:CNGC6
Ordered Locus Names:At2g23980
ORF Names:T29E15.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G23980
TAIRilocus:2061401 AT2G23980

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 117CytoplasmicSequence analysisAdd BLAST117
Transmembranei118 – 138Helical; Name=H1Sequence analysisAdd BLAST21
Topological domaini139 – 150ExtracellularSequence analysisAdd BLAST12
Transmembranei151 – 171Helical; Name=H2Sequence analysisAdd BLAST21
Topological domaini172 – 205CytoplasmicSequence analysisAdd BLAST34
Transmembranei206 – 226Helical; Name=H3Sequence analysisAdd BLAST21
Topological domaini227 – 239ExtracellularSequence analysisAdd BLAST13
Transmembranei240 – 260Helical; Name=H4Sequence analysisAdd BLAST21
Topological domaini261 – 280CytoplasmicSequence analysisAdd BLAST20
Transmembranei281 – 301Helical; Name=H5Sequence analysisAdd BLAST21
Topological domaini302 – 407ExtracellularSequence analysisAdd BLAST106
Transmembranei408 – 428Helical; Name=H6Sequence analysisAdd BLAST21
Topological domaini429 – 747CytoplasmicSequence analysisAdd BLAST319

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193341 – 747Probable cyclic nucleotide-gated ion channel 6Add BLAST747

Proteomic databases

PaxDbiO82226
PRIDEiO82226

PTM databases

iPTMnetiO82226

Expressioni

Gene expression databases

ExpressionAtlasiO82226 baseline and differential
GenevisibleiO82226 AT

Interactioni

Subunit structurei

Homotetramer or heterotetramer.Curated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2283, 17 interactors
STRINGi3702.AT2G23980.1

Structurei

Secondary structure

1747
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi514 – 516Combined sources3
Helixi520 – 529Combined sources10
Beta strandi539 – 542Combined sources4
Beta strandi549 – 556Combined sources8
Beta strandi560 – 562Combined sources3
Beta strandi568 – 572Combined sources5
Beta strandi574 – 576Combined sources3
Beta strandi582 – 584Combined sources3
Helixi586 – 592Combined sources7
Beta strandi598 – 600Combined sources3
Beta strandi604 – 611Combined sources8
Beta strandi613 – 619Combined sources7
Helixi620 – 630Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGPNMR-A509-632[»]
ProteinModelPortaliO82226
SMRiO82226
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO82226

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini650 – 679IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni630 – 645Calmodulin-bindingBy similarityAdd BLAST16

Domaini

The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0498 Eukaryota
ENOG410XPSE LUCA
HOGENOMiHOG000238338
InParanoidiO82226
KOiK05391
OMAiNQNCTRN
OrthoDBiEOG093603N1
PhylomeDBiO82226

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS50096 IQ, 1 hit

Sequencei

Sequence statusi: Complete.

O82226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDTCGPKGV KSQVISGQRE NFVRLDSMDS RYSQSSETGL NKCTLNIQGG
60 70 80 90 100
PKRFAQGSKA SSGSFKKGFR KGSEGLWSIG RSIGLGVSRA VFPEDLEVSE
110 120 130 140 150
KKIFDPQDKF LLLCNKLFVA SCILAVSVDP LFLYLPFIND KAKCVGIDRK
160 170 180 190 200
LAIIVTTIRT VIDSFYLFHM ALRFRTAYVA PSSRVFGRGE LVIDPAQIAK
210 220 230 240 250
RYLQQYFIID LLSVLPVPQI IVWRFLYTSR GANVLATKQA LRYIVLVQYI
260 270 280 290 300
PRFLRMYPLS SELKRTAGVF AETAWAGAAY YLLLYMLASH IVGALWYLLA
310 320 330 340 350
LERNNDCWSK ACHNNQNCTR NFLFCGNQNM KGYAAWDNIK VSYLQLKCPV
360 370 380 390 400
NVPEDEEPPF DFGIYLRALS SGIVSSKNFV SKYFFCLWWG LQNLSTLGQG
410 420 430 440 450
LETSTYPGEV IFSITLAIAG LLLFALLIGN MQTYLQSLTI RLEEMRVKRR
460 470 480 490 500
DSEQWMHHRM LPPELRERVR RYDQYKWLET RGVDEENLVQ NLPKDLRRDI
510 520 530 540 550
KRHLCLALVR RVPLFENMDE RLLDAICERL KPCLFTEKSY LVREGDPVNE
560 570 580 590 600
MLFIIRGRLE SVTTDGGRSG FYNRSLLKEG DFCGDELLTW ALDPKSGSNL
610 620 630 640 650
PSSTRTVKAL TEVEAFALIA DELKFVASQF RRLHSRQVQH TFRFYSQQWR
660 670 680 690 700
TWAACFMQAA WRRYIKRKKL EQLRKEEEEE EAAAASVIAG GSPYSIRATF
710 720 730 740
LASKFAANAL RSVHKNRTAK STLLLSSTKE LVKFQKPPEP DFSAEDH
Length:747
Mass (Da):85,441
Last modified:June 1, 2002 - v2
Checksum:i601234797E44700F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17914 mRNA Translation: CAB40131.1
AC005170 Genomic DNA Translation: AAC63666.2
CP002685 Genomic DNA Translation: AEC07510.1
CP002685 Genomic DNA Translation: ANM61675.1
CP002685 Genomic DNA Translation: ANM61676.1
CP002685 Genomic DNA Translation: ANM61680.1
CP002685 Genomic DNA Translation: ANM61682.1
PIRiB84631
T52572
RefSeqiNP_001318278.1, NM_001335878.1
NP_001323879.1, NM_001335882.1
NP_001323883.1, NM_001335886.1
NP_001323885.1, NM_001335881.1
NP_565560.1, NM_127960.3
UniGeneiAt.402

Genome annotation databases

EnsemblPlantsiAT2G23980.1; AT2G23980.1; AT2G23980
AT2G23980.10; AT2G23980.10; AT2G23980
AT2G23980.4; AT2G23980.4; AT2G23980
AT2G23980.5; AT2G23980.5; AT2G23980
AT2G23980.9; AT2G23980.9; AT2G23980
GeneIDi816931
GrameneiAT2G23980.1; AT2G23980.1; AT2G23980
AT2G23980.10; AT2G23980.10; AT2G23980
AT2G23980.4; AT2G23980.4; AT2G23980
AT2G23980.5; AT2G23980.5; AT2G23980
AT2G23980.9; AT2G23980.9; AT2G23980
KEGGiath:AT2G23980

Similar proteinsi

Entry informationi

Entry nameiCNGC6_ARATH
AccessioniPrimary (citable) accession number: O82226
Secondary accession number(s): Q9XFS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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