O82210 (ANM12_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable protein arginine N-methyltransferase 1.2
Short name=AtPRMT12
EC=2.1.1.-

Gene names

Name:	PRMT12
Synonyms:	PRMT1.2
Ordered Locus Names:	At2g19670
ORF Names:	F6F22.30

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (can methylate histones) By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the protein arginine N-methyltransferase family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from direct assay. Source: TAIR nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Probable protein arginine N-methyltransferase 1.2		PRO_0000293987
Regions
	Compositional bias	6 – 9	4	Poly-Asn

Sequences

	Sequence		Length	Mass (Da)
	O82210 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 9C31A654BDCC4C70	FASTA	366	41,172
	10 20 30 40 50 60 MTSTENNNNG SDETQTTKLH FEDADESMHD GDDNNADVAD DITSADYYFD SYSHFGIHEE 70 80 90 100 110 120 MLKDVVRTKS YQDVIYKNKF LIKDKIVLDV GAGTGILSLF CAKAGAAHVY AVECSQMADT 130 140 150 160 170 180 AKEIVKSNGF SDVITVLKGK IEEIELPVPK VDVIISEWMG YFLLYENMLD TVLYARNKWL 190 200 210 220 230 240 VDGGIVLPDK ASLYVTAIED AHYKDDKVEF WDDVYGFDMS CIKRRAITEP LVDTVDGNQI 250 260 270 280 290 300 VTDSKLLKTM DISKMAAGDA SFTAPFKLVA QRNDHIHALV AYFDVSFTMC HKKMGFSTGP 310 320 330 340 350 360 KSRATHWKQT VLYLEDVLTI CEGETITGSM TIAQNKKNPR DVDIKLSYSL NGQHCNISRT HFYKMR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[5]	"Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential." Krause C.D., Yang Z.-H., Kim Y.-S., Lee J.-H., Cook J.R., Pestka S. Pharmacol. Ther. 113:50-87(2007) [PubMed: 17005254] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Web resources

The Chromatin Database (ChromDB)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC005169 Genomic DNA. Translation: AAC62148.1. CP002685 Genomic DNA. Translation: AEC06910.1. BT006491 mRNA. Translation: AAP21299.1. AK227449 mRNA. Translation: BAE99452.1.
IPI	IPI00540969.
PIR	F84579.
RefSeq	NP_179557.1. NM_127525.4.
UniGene	At.39807.
3D structure databases
HSSP	HSSP built from PDB template 1ORH based on UniProtKB Q63009.
ProteinModelPortal	O82210.
SMR	O82210. Positions 49-366.
ModBase	Search...
Protein-protein interaction databases
IntAct	O82210. 2 interactions.
STRING	O82210.
Proteomic databases
PRIDE	O82210.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT2G19670.1; AT2G19670.1; AT2G19670.
GeneID	816486.
GenomeReviews	Gene locus AT2G19670 in contig CT485783_GR.
KEGG	ath:AT2G19670.
NMPDR	fig|3702.1.peg.8961.
Organism-specific databases
TAIR	At2g19670.
Phylogenomic databases
eggNOG	KOG1499.
GeneTree	EPGT00070000028859.
HOGENOM	HBG715060.
InParanoid	O82210.
OMA	VKRNDYI.
PhylomeDB	O82210.
ProtClustDB	CLSN2683188.
Gene expression databases
ArrayExpress	O82210.
Genevestigator	O82210.
Family and domain databases
InterPro	IPR010456. Ribosomal-L11_MeTrfase_PrmA. [Graphical view]
KO	K11434.
Pfam	PF06325. PrmA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANM12_ARATH

Accession

Primary (citable) accession number: O82210

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	November 1, 1998
Last modified:	November 16, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program