Reviewed, UniProtKB/Swiss-Prot O82210 (ANM12_ARATH)

Names and origin

Protein names

Recommended name:
    Probable protein arginine N-methyltransferase 1.2
    EC=2.1.1.-

Gene names

Name:	PRMT1.2
Ordered Locus Names:	At2g19670
ORF Names:	F6F22.30

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (can methylate histones) By similarity.
Subcellular location	NucleusBy similarity.
Sequence similarities	Belongs to the protein arginine N-methyltransferase family.

Ontologies

Keywords
Cellular component	Nucleus
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FIB2	Q94AH9	1	EBI-1382526,EBI-1382666
HIST1H4A	P62805	1	EBI-1382526,EBI-302023	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Probable protein arginine N-methyltransferase 1.2		PRO_0000293987
Regions
	Compositional bias	6 – 9	4	Poly-Asn

Sequences

	Sequence		Length	Mass (Da)
	O82210-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 9C31A654BDCC4C70	FASTA	366	41,172
	10 20 30 40 50 60 MTSTENNNNG SDETQTTKLH FEDADESMHD GDDNNADVAD DITSADYYFD SYSHFGIHEE 70 80 90 100 110 120 MLKDVVRTKS YQDVIYKNKF LIKDKIVLDV GAGTGILSLF CAKAGAAHVY AVECSQMADT 130 140 150 160 170 180 AKEIVKSNGF SDVITVLKGK IEEIELPVPK VDVIISEWMG YFLLYENMLD TVLYARNKWL 190 200 210 220 230 240 VDGGIVLPDK ASLYVTAIED AHYKDDKVEF WDDVYGFDMS CIKRRAITEP LVDTVDGNQI 250 260 270 280 290 300 VTDSKLLKTM DISKMAAGDA SFTAPFKLVA QRNDHIHALV AYFDVSFTMC HKKMGFSTGP 310 320 330 340 350 360 KSRATHWKQT VLYLEDVLTI CEGETITGSM TIAQNKKNPR DVDIKLSYSL NGQHCNISRT HFYKMR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[3]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential." Krause C.D., Yang Z.H., Kim Y.S., Lee J.H., Cook J.R., Pestka S. Pharmacol. Ther. 113:50-87(2007) [PubMed: 17005254] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC005169 Genomic DNA. Translation: AAC62148.1. BT006491 mRNA. Translation: AAP21299.1. AK227449 mRNA. Translation: BAE99452.1.
PIR	F84579.
RefSeq	NP_179557.1.
UniGene	At.39807
3D structure databases
HSSP	HSSP built from PDB template 1ORH based on UniProtKB Q63009.
ModBase	Search...
Protein-protein interaction databases
IntAct	O82210.
Genome annotation databases
GeneID	816486.
GenomeReviews	Gene locus AT2G19670 in contig CT485783_GR.
KEGG	ath:AT2G19670.
NMPDR	fig|3702.1.peg.8961.
Organism-specific databases
TAIR	At2g19670.
Gene expression databases
ArrayExpress	O82210.
Family and domain databases
InterPro	IPR013217. Methyltransf_12. [Graphical view]
Pfam	PF08242. Methyltransf_12. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANM12_ARATH

Accession

Primary (citable) accession number: O82210

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	November 1, 1998
Last modified:	November 25, 2008
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)