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Protein

Glycine cleavage system H protein 2, mitochondrial

Gene

GDH2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The glycine decarboxylase (GDC) or glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity).By similarity

Cofactori

(R)-lipoateBy similarityNote: Binds 1 lipoyl cofactor covalently.By similarity

GO - Molecular functioni

  • ATP binding Source: TAIR

GO - Biological processi

Enzyme and pathway databases

BioCyciARA:AT2G35120-MONOMER
MetaCyc:MONOMER-907
ReactomeiR-ATH-389661 Glyoxylate metabolism and glycine degradation
R-ATH-6783984 Glycine degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine cleavage system H protein 2, mitochondrial
Gene namesi
Name:GDH2
Ordered Locus Names:At2g35120
ORF Names:T4C15.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G35120
TAIRilocus:2063464 AT2G35120

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23MitochondrionSequence analysisAdd BLAST23
ChainiPRO_000042228624 – 156Glycine cleavage system H protein 2, mitochondrialAdd BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88N6-lipoyllysinePROSITE-ProRule annotationBy similarity1
Modified residuei131PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO82179
PRIDEiO82179

Expressioni

Gene expression databases

GenevisibleiO82179 AT

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.

Protein-protein interaction databases

STRINGi3702.AT2G35120.1

Structurei

3D structure databases

ProteinModelPortaliO82179
SMRiO82179
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 129Lipoyl-bindingPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Belongs to the GcvH family.Curated

Keywords - Domaini

Lipoyl, Transit peptide

Phylogenomic databases

eggNOGiKOG3373 Eukaryota
COG0509 LUCA
HOGENOMiHOG000239392
KOiK02437
OMAiIVYVEVE
OrthoDBiEOG09360PSV
PhylomeDBiO82179

Family and domain databases

CDDicd06848 GCS_H, 1 hit
HAMAPiMF_00272 GcvH, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR000089 Biotin_lipoyl
IPR002930 GCV_H
IPR033753 GCV_H/Fam206
IPR017453 GCV_H_sub
IPR011053 Single_hybrid_motif
PANTHERiPTHR11715 PTHR11715, 1 hit
PfamiView protein in Pfam
PF01597 GCV_H, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR00527 gcvH, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O82179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACRLFWASR VASHLRISVA QRGFSSVVLK DLKYADSHEW VKIDGNKATF
60 70 80 90 100
GITDHAQDHL GDVVYVELPD VGHSVSQGKS FGAVESVKAT SDINSPVSGK
110 120 130 140 150
VVEVNEELTE SPGLVNSSPY EQGWIIKVEL SDAGEAEKLM DSDKYSKFCE

EEDAKH
Length:156
Mass (Da):17,100
Last modified:November 1, 1998 - v1
Checksum:iA8098D7174695749
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004667 Genomic DNA Translation: AAC61829.1
CP002685 Genomic DNA Translation: AEC09067.1
AY056106 mRNA Translation: AAL06993.1
AY060493 mRNA Translation: AAL31106.1
AK227751 mRNA Translation: BAE99735.1
PIRiH84764
RefSeqiNP_181057.1, NM_129065.4
UniGeneiAt.12721

Genome annotation databases

EnsemblPlantsiAT2G35120.1; AT2G35120.1; AT2G35120
GeneIDi818078
GrameneiAT2G35120.1; AT2G35120.1; AT2G35120
KEGGiath:AT2G35120

Similar proteinsi

Entry informationi

Entry nameiGCSH2_ARATH
AccessioniPrimary (citable) accession number: O82179
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health