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Protein

Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5

Gene

SUVH5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • chromatin silencing by small RNA Source: TAIR
  • histone methylation Source: TAIR
  • regulation of gene expression, epigenetic Source: TAIR
  • response to chitin Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciARA:AT2G35160-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 (EC:2.1.1.43)
Alternative name(s):
Histone H3-K9 methyltransferase 5
Short name:
H3-K9-HMTase 5
Protein SET DOMAIN GROUP 9
Suppressor of variegation 3-9 homolog protein 5
Short name:
Su(var)3-9 homolog protein 5
Gene namesi
Name:SUVH5
Synonyms:SDG9, SET9
Ordered Locus Names:At2g35160
ORF Names:T4C15.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G35160.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosomecentromere By similarity

  • Note: Associates with centromeric constitutive heterochromatin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 794794Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5PRO_0000186076Add
BLAST

Proteomic databases

PaxDbiO82175.
PRIDEiO82175.

Expressioni

Tissue specificityi

Expressed in leaves stems and flowers.1 Publication

Gene expression databases

GenevisibleiO82175. AT.

Interactioni

Protein-protein interaction databases

BioGridi3429. 2 interactions.
IntActiO82175. 2 interactions.
STRINGi3702.AT2G35160.1.

Structurei

Secondary structure

1
794
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi375 – 3773Combined sources
Helixi379 – 3846Combined sources
Beta strandi394 – 3996Combined sources
Beta strandi401 – 4033Combined sources
Beta strandi405 – 41511Combined sources
Beta strandi422 – 4298Combined sources
Helixi451 – 46212Combined sources
Beta strandi466 – 4716Combined sources
Beta strandi486 – 50116Combined sources
Beta strandi503 – 5053Combined sources
Beta strandi507 – 5159Combined sources
Beta strandi517 – 5193Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q0BX-ray2.20X362-528[»]
3Q0CX-ray2.66A/X362-528[»]
3Q0DX-ray2.37A/X362-528[»]
3Q0FX-ray2.75A/X362-528[»]
4YGIX-ray2.60A362-528[»]
ProteinModelPortaliO82175.
SMRiO82175. Positions 309-794.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO82175.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini365 – 515151YDGPROSITE-ProRule annotationAdd
BLAST
Domaini585 – 64460Pre-SETPROSITE-ProRule annotationAdd
BLAST
Domaini647 – 764118SETPROSITE-ProRule annotationAdd
BLAST
Domaini778 – 79417Post-SETPROSITE-ProRule annotationAdd
BLAST

Domaini

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity.

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 pre-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation
Contains 1 YDG domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
COG3440. LUCA.
HOGENOMiHOG000154454.
InParanoidiO82175.
KOiK11420.
OMAiKETLPIC.
PhylomeDBiO82175.

Family and domain databases

Gene3Di2.30.280.10. 1 hit.
InterProiIPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O82175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHSESSILS SLRGGDGGGI PCSKDELAIN GSYTDPMGRR KSKRFKVAAE
60 70 80 90 100
SEFSPDFGSI TRQLRSRRMQ KEFTVETYET RNVSDVCVLS SQADVELIPG
110 120 130 140 150
EIVAERDSFK SVDCNDMSVG LTEGAESLGV NMQEPMKDRN MPENTSEQNM
160 170 180 190 200
VEVHPPSISL PEEDMMGSVC RKSITGTKEL HGRTISVGRD LSPNMGSKFS
210 220 230 240 250
KNGKTAKRSI SVEEENLVLE KSDSGDHLGP SPEVLELEKS EVWIITDKGV
260 270 280 290 300
VMPSPVKPSE KRNGDYGEGS MRKNSERVAL DKKRLASKFR LSNGGLPSCS
310 320 330 340 350
SSGDSARYKV KETMRLFHET CKKIMQEEEA RPRKRDGGNF KVVCEASKIL
360 370 380 390 400
KSKGKNLYSG TQIIGTVPGV EVGDEFQYRM ELNLLGIHRP SQSGIDYMKD
410 420 430 440 450
DGGELVATSI VSSGGYNDVL DNSDVLIYTG QGGNVGKKKN NEPPKDQQLV
460 470 480 490 500
TGNLALKNSI NKKNPVRVIR GIKNTTLQSS VVAKNYVYDG LYLVEEYWEE
510 520 530 540 550
TGSHGKLVFK FKLRRIPGQP ELPWKEVAKS KKSEFRDGLC NVDITEGKET
560 570 580 590 600
LPICAVNNLD DEKPPPFIYT AKMIYPDWCR PIPPKSCGCT NGCSKSKNCA
610 620 630 640 650
CIVKNGGKIP YYDGAIVEIK PLVYECGPHC KCPPSCNMRV SQHGIKIKLE
660 670 680 690 700
IFKTESRGWG VRSLESIPIG SFICEYAGEL LEDKQAESLT GKDEYLFDLG
710 720 730 740 750
DEDDPFTINA AQKGNIGRFI NHSCSPNLYA QDVLYDHEEI RIPHIMFFAL
760 770 780 790
DNIPPLQELS YDYNYKIDQV YDSNGNIKKK FCYCGSAECS GRLY
Length:794
Mass (Da):88,153
Last modified:November 1, 1998 - v1
Checksum:i9C3BB4FA62885F17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF344448 mRNA. Translation: AAK28970.1.
AC004667 Genomic DNA. Translation: AAC61820.1.
CP002685 Genomic DNA. Translation: AEC09075.1.
AY062735 mRNA. Translation: AAL32813.1.
BT003374 mRNA. Translation: AAO30037.1.
PIRiD84765.
RefSeqiNP_181061.1. NM_129070.2.
UniGeneiAt.12724.

Genome annotation databases

EnsemblPlantsiAT2G35160.1; AT2G35160.1; AT2G35160.
GeneIDi818083.
GrameneiAT2G35160.1; AT2G35160.1; AT2G35160.
KEGGiath:AT2G35160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF344448 mRNA. Translation: AAK28970.1.
AC004667 Genomic DNA. Translation: AAC61820.1.
CP002685 Genomic DNA. Translation: AEC09075.1.
AY062735 mRNA. Translation: AAL32813.1.
BT003374 mRNA. Translation: AAO30037.1.
PIRiD84765.
RefSeqiNP_181061.1. NM_129070.2.
UniGeneiAt.12724.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q0BX-ray2.20X362-528[»]
3Q0CX-ray2.66A/X362-528[»]
3Q0DX-ray2.37A/X362-528[»]
3Q0FX-ray2.75A/X362-528[»]
4YGIX-ray2.60A362-528[»]
ProteinModelPortaliO82175.
SMRiO82175. Positions 309-794.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi3429. 2 interactions.
IntActiO82175. 2 interactions.
STRINGi3702.AT2G35160.1.

Proteomic databases

PaxDbiO82175.
PRIDEiO82175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G35160.1; AT2G35160.1; AT2G35160.
GeneIDi818083.
GrameneiAT2G35160.1; AT2G35160.1; AT2G35160.
KEGGiath:AT2G35160.

Organism-specific databases

TAIRiAT2G35160.

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
COG3440. LUCA.
HOGENOMiHOG000154454.
InParanoidiO82175.
KOiK11420.
OMAiKETLPIC.
PhylomeDBiO82175.

Enzyme and pathway databases

BioCyciARA:AT2G35160-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO82175.
PROiO82175.

Gene expression databases

GenevisibleiO82175. AT.

Family and domain databases

Gene3Di2.30.280.10. 1 hit.
InterProiIPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes."
    Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B.
    Nucleic Acids Res. 29:4319-4333(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis."
    Fischer A., Hofmann I., Naumann K., Reuter G.
    J. Plant Physiol. 163:358-368(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiSUVH5_ARATH
AccessioniPrimary (citable) accession number: O82175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.