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Protein

Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5

Gene

SUVH5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • chromatin silencing by small RNA Source: TAIR
  • histone methylation Source: TAIR
  • regulation of gene expression, epigenetic Source: TAIR
  • response to chitin Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 (EC:2.1.1.43)
Alternative name(s):
Histone H3-K9 methyltransferase 5
Short name:
H3-K9-HMTase 5
Protein SET DOMAIN GROUP 9
Suppressor of variegation 3-9 homolog protein 5
Short name:
Su(var)3-9 homolog protein 5
Gene namesi
Name:SUVH5
Synonyms:SDG9, SET9
Ordered Locus Names:At2g35160
ORF Names:T4C15.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G35160.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosomecentromere By similarity

  • Note: Associates with centromeric constitutive heterochromatin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001860761 – 794Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5Add BLAST794

Proteomic databases

PaxDbiO82175.
PRIDEiO82175.

Expressioni

Tissue specificityi

Expressed in leaves stems and flowers.1 Publication

Gene expression databases

GenevisibleiO82175. AT.

Interactioni

Protein-protein interaction databases

BioGridi3429. 2 interactors.
DIPiDIP-62060N.
IntActiO82175. 2 interactors.
STRINGi3702.AT2G35160.1.

Structurei

Secondary structure

1794
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi375 – 377Combined sources3
Helixi379 – 384Combined sources6
Beta strandi394 – 399Combined sources6
Beta strandi401 – 403Combined sources3
Beta strandi405 – 415Combined sources11
Beta strandi422 – 429Combined sources8
Helixi451 – 462Combined sources12
Beta strandi466 – 471Combined sources6
Beta strandi486 – 501Combined sources16
Beta strandi503 – 505Combined sources3
Beta strandi507 – 515Combined sources9
Beta strandi517 – 519Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q0BX-ray2.20X362-528[»]
3Q0CX-ray2.66A/X362-528[»]
3Q0DX-ray2.37A/X362-528[»]
3Q0FX-ray2.75A/X362-528[»]
4YGIX-ray2.60A362-528[»]
ProteinModelPortaliO82175.
SMRiO82175.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO82175.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini365 – 515YDGPROSITE-ProRule annotationAdd BLAST151
Domaini585 – 644Pre-SETPROSITE-ProRule annotationAdd BLAST60
Domaini647 – 764SETPROSITE-ProRule annotationAdd BLAST118
Domaini778 – 794Post-SETPROSITE-ProRule annotationAdd BLAST17

Domaini

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity.

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 pre-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation
Contains 1 YDG domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
COG3440. LUCA.
HOGENOMiHOG000154454.
InParanoidiO82175.
KOiK11420.
OMAiKETLPIC.
OrthoDBiEOG093600X5.
PhylomeDBiO82175.

Family and domain databases

Gene3Di2.30.280.10. 1 hit.
InterProiIPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O82175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHSESSILS SLRGGDGGGI PCSKDELAIN GSYTDPMGRR KSKRFKVAAE
60 70 80 90 100
SEFSPDFGSI TRQLRSRRMQ KEFTVETYET RNVSDVCVLS SQADVELIPG
110 120 130 140 150
EIVAERDSFK SVDCNDMSVG LTEGAESLGV NMQEPMKDRN MPENTSEQNM
160 170 180 190 200
VEVHPPSISL PEEDMMGSVC RKSITGTKEL HGRTISVGRD LSPNMGSKFS
210 220 230 240 250
KNGKTAKRSI SVEEENLVLE KSDSGDHLGP SPEVLELEKS EVWIITDKGV
260 270 280 290 300
VMPSPVKPSE KRNGDYGEGS MRKNSERVAL DKKRLASKFR LSNGGLPSCS
310 320 330 340 350
SSGDSARYKV KETMRLFHET CKKIMQEEEA RPRKRDGGNF KVVCEASKIL
360 370 380 390 400
KSKGKNLYSG TQIIGTVPGV EVGDEFQYRM ELNLLGIHRP SQSGIDYMKD
410 420 430 440 450
DGGELVATSI VSSGGYNDVL DNSDVLIYTG QGGNVGKKKN NEPPKDQQLV
460 470 480 490 500
TGNLALKNSI NKKNPVRVIR GIKNTTLQSS VVAKNYVYDG LYLVEEYWEE
510 520 530 540 550
TGSHGKLVFK FKLRRIPGQP ELPWKEVAKS KKSEFRDGLC NVDITEGKET
560 570 580 590 600
LPICAVNNLD DEKPPPFIYT AKMIYPDWCR PIPPKSCGCT NGCSKSKNCA
610 620 630 640 650
CIVKNGGKIP YYDGAIVEIK PLVYECGPHC KCPPSCNMRV SQHGIKIKLE
660 670 680 690 700
IFKTESRGWG VRSLESIPIG SFICEYAGEL LEDKQAESLT GKDEYLFDLG
710 720 730 740 750
DEDDPFTINA AQKGNIGRFI NHSCSPNLYA QDVLYDHEEI RIPHIMFFAL
760 770 780 790
DNIPPLQELS YDYNYKIDQV YDSNGNIKKK FCYCGSAECS GRLY
Length:794
Mass (Da):88,153
Last modified:November 1, 1998 - v1
Checksum:i9C3BB4FA62885F17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF344448 mRNA. Translation: AAK28970.1.
AC004667 Genomic DNA. Translation: AAC61820.1.
CP002685 Genomic DNA. Translation: AEC09075.1.
AY062735 mRNA. Translation: AAL32813.1.
BT003374 mRNA. Translation: AAO30037.1.
PIRiD84765.
RefSeqiNP_181061.1. NM_129070.3.
UniGeneiAt.12724.

Genome annotation databases

EnsemblPlantsiAT2G35160.1; AT2G35160.1; AT2G35160.
GeneIDi818083.
GrameneiAT2G35160.1; AT2G35160.1; AT2G35160.
KEGGiath:AT2G35160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF344448 mRNA. Translation: AAK28970.1.
AC004667 Genomic DNA. Translation: AAC61820.1.
CP002685 Genomic DNA. Translation: AEC09075.1.
AY062735 mRNA. Translation: AAL32813.1.
BT003374 mRNA. Translation: AAO30037.1.
PIRiD84765.
RefSeqiNP_181061.1. NM_129070.3.
UniGeneiAt.12724.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q0BX-ray2.20X362-528[»]
3Q0CX-ray2.66A/X362-528[»]
3Q0DX-ray2.37A/X362-528[»]
3Q0FX-ray2.75A/X362-528[»]
4YGIX-ray2.60A362-528[»]
ProteinModelPortaliO82175.
SMRiO82175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi3429. 2 interactors.
DIPiDIP-62060N.
IntActiO82175. 2 interactors.
STRINGi3702.AT2G35160.1.

Proteomic databases

PaxDbiO82175.
PRIDEiO82175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G35160.1; AT2G35160.1; AT2G35160.
GeneIDi818083.
GrameneiAT2G35160.1; AT2G35160.1; AT2G35160.
KEGGiath:AT2G35160.

Organism-specific databases

TAIRiAT2G35160.

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
COG3440. LUCA.
HOGENOMiHOG000154454.
InParanoidiO82175.
KOiK11420.
OMAiKETLPIC.
OrthoDBiEOG093600X5.
PhylomeDBiO82175.

Miscellaneous databases

EvolutionaryTraceiO82175.
PROiO82175.

Gene expression databases

GenevisibleiO82175. AT.

Family and domain databases

Gene3Di2.30.280.10. 1 hit.
InterProiIPR025794. Hist-Lys_N-MeTrfase_plant.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR015947. PUA-like_domain.
IPR001214. SET_dom.
IPR003105. SRA_YDG.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF02182. SAD_SRA. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00466. SRA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51575. SAM_MT43_SUVAR39_2. 1 hit.
PS50280. SET. 1 hit.
PS51015. YDG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUVH5_ARATH
AccessioniPrimary (citable) accession number: O82175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.