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O82144

- CHSY_HYDMC

UniProt

O82144 - CHSY_HYDMC

Protein

Chalcone synthase

Gene

CHS

Organism
Hydrangea macrophylla (Bigleaf hydrangea)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    • Comment

    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei164 – 1641PROSITE-ProRule annotation

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase (EC:2.3.1.74)
    Alternative name(s):
    Naringenin-chalcone synthase
    Gene namesi
    Name:CHS
    OrganismiHydrangea macrophylla (Bigleaf hydrangea)
    Taxonomic identifieri23110 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridsCornalesHydrangeaceaeHydrangea

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Chalcone synthasePRO_0000215981Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO82144.
    SMRiO82144. Positions 3-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O82144-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTVEEVRKA QRAEGPATIL AIGTATPPNY VDQSTYPDFY FRVTNSEHKK    50
    ELKAKFQRMC DNSQIKKRYM HLTEEILKEN PNICAYMAPS LDARQDMVVV 100
    EIPKLGKEAA TRAIKEWGQP KSKITHLVFC TTSGVDMPGA DYQLTKLLGL 150
    RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITAVTFRG 200
    PSDTHLDSLV GQALFGDGAA AVIIGSDPMP EVEKPLFEIV SAAQTILPDS 250
    DGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLVEAFRPL DISDWNSIFW 300
    IAHPGGPAIL DQVEKKLALK PEKLRATRNV LSDYGNMSSA CVLFIMDEMR 350
    KNSAEEGLMT TGEGLEWGVL FGFGPGLTVE TVVLHGVST 389
    Length:389
    Mass (Da):42,635
    Last modified:November 1, 1998 - v1
    Checksum:i187FC9CB9F33F568
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011467 mRNA. Translation: BAA32732.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011467 mRNA. Translation: BAA32732.1 .

    3D structure databases

    ProteinModelPortali O82144.
    SMRi O82144. Positions 3-388.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of polyketide synthases from Hydrangea macrophylla var. thunbergii."
      Akiyama T., Shibuya M., Ebizuka Y.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Var. Thunbergii.
      Tissue: Leaf.

    Entry informationi

    Entry nameiCHSY_HYDMC
    AccessioniPrimary (citable) accession number: O82144
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3