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Protein

Glucose-6-phosphate isomerase, cytosolic

Gene

PGIC

Organism
Spinacia oleracea (Spinach)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei360 – 3601Proton donorBy similarity
Active sitei391 – 3911By similarity
Active sitei516 – 5161By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

SABIO-RKO82059.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase, cytosolic (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:PGIC
Synonyms:GPIS
OrganismiSpinacia oleracea (Spinach)
Taxonomic identifieri3562 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeChenopodioideaeAnserineaeSpinacia

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Glucose-6-phosphate isomerase, cytosolicPRO_0000180568Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO82059.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O82059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSTLICDT DSWQNLKTHV AEIKKTHLRD LMSDADRCKS MMVEFDGLLL
60 70 80 90 100
DYSRQNATHD TMSKLFQLAE ASHLKDKINQ MFNGEHINST ENRSVLHVAL
110 120 130 140 150
RASRDAVING DGKNVVPDVW QVLDKIRDFS EKIRSGSWVG VTGKPLTNVV
160 170 180 190 200
AVGIGGSFLG PLFVHTALQT ESEAAECAKG RQLRFLANVD PIDVAKNISG
210 220 230 240 250
LNPETTLVVV VSKTFTTAET MLNARTLREW ISSALGPAAV AKHMVAVSTN
260 270 280 290 300
LTLVEKFGID PKNAFAFWDW VGGRYSVCSA VGVLPLSLQY GFPIVEKFLK
310 320 330 340 350
GASSIDQHFH SAPLEKNLPV LLGLLSLWNV SFLGHPARAI LPYCQALEKF
360 370 380 390 400
APHIQQVSME SNGKGVSIDG VVLPFEAGEI DFGEPGTNGQ HSFYQLIHQG
410 420 430 440 450
RVIPCDFIGI AKSQQPVYLK GEVVSNHDEL MSNFFAQPDA LAYGKTQEEL
460 470 480 490 500
QKENISPHLV PHKTFTGNRP SLSLLLPSLT AYNVGQLLAI YEHRVAVEGF
510 520 530 540 550
VWGINSFDQW GVELGKSLAN QVRKQLHASR TNGEAVKGFN FSTTTVMAKY
560
LQETSDVPAE LPTKLP
Length:566
Mass (Da):62,130
Last modified:June 21, 2004 - v2
Checksum:i6079EE5D3A53460A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000266 mRNA. Translation: CAA03983.1.
PIRiT09154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000266 mRNA. Translation: CAA03983.1.
PIRiT09154.

3D structure databases

ProteinModelPortaliO82059.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
SABIO-RKO82059.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Eubacterial origin of nuclear genes for chloroplast and cytosolic glucose-6-phosphate isomerase from spinach: sampling eubacterial gene diversity in eukaryotic chromosomes through symbiosis."
    Nowitzki U., Flechner A., Kellermann J., Hasegawa M., Schnarrenberger C., Martin W.
    Gene 214:205-213(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiG6PI_SPIOL
AccessioniPrimary (citable) accession number: O82059
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: June 21, 2004
Last modified: January 7, 2015
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.