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O82059 (G6PI_SPIOL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase, cytosolic

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:PGIC
Synonyms:GPIS
OrganismSpinacia oleracea (Spinach)
Taxonomic identifier3562 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeChenopodioideaeAnserineaeSpinacia

Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Glucose-6-phosphate isomerase, cytosolic HAMAP-Rule MF_00473
PRO_0000180568

Sites

Active site3601Proton donor By similarity
Active site3911 By similarity
Active site5161 By similarity

Sequences

Sequence LengthMass (Da)Tools
O82059 [UniParc].

Last modified June 21, 2004. Version 2.
Checksum: 6079EE5D3A53460A

FASTA56662,130
        10         20         30         40         50         60 
MAPSTLICDT DSWQNLKTHV AEIKKTHLRD LMSDADRCKS MMVEFDGLLL DYSRQNATHD 

        70         80         90        100        110        120 
TMSKLFQLAE ASHLKDKINQ MFNGEHINST ENRSVLHVAL RASRDAVING DGKNVVPDVW 

       130        140        150        160        170        180 
QVLDKIRDFS EKIRSGSWVG VTGKPLTNVV AVGIGGSFLG PLFVHTALQT ESEAAECAKG 

       190        200        210        220        230        240 
RQLRFLANVD PIDVAKNISG LNPETTLVVV VSKTFTTAET MLNARTLREW ISSALGPAAV 

       250        260        270        280        290        300 
AKHMVAVSTN LTLVEKFGID PKNAFAFWDW VGGRYSVCSA VGVLPLSLQY GFPIVEKFLK 

       310        320        330        340        350        360 
GASSIDQHFH SAPLEKNLPV LLGLLSLWNV SFLGHPARAI LPYCQALEKF APHIQQVSME 

       370        380        390        400        410        420 
SNGKGVSIDG VVLPFEAGEI DFGEPGTNGQ HSFYQLIHQG RVIPCDFIGI AKSQQPVYLK 

       430        440        450        460        470        480 
GEVVSNHDEL MSNFFAQPDA LAYGKTQEEL QKENISPHLV PHKTFTGNRP SLSLLLPSLT 

       490        500        510        520        530        540 
AYNVGQLLAI YEHRVAVEGF VWGINSFDQW GVELGKSLAN QVRKQLHASR TNGEAVKGFN 

       550        560 
FSTTTVMAKY LQETSDVPAE LPTKLP 

« Hide

References

[1]"Eubacterial origin of nuclear genes for chloroplast and cytosolic glucose-6-phosphate isomerase from spinach: sampling eubacterial gene diversity in eukaryotic chromosomes through symbiosis."
Nowitzki U., Flechner A., Kellermann J., Hasegawa M., Schnarrenberger C., Martin W.
Gene 214:205-213(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ000266 mRNA. Translation: CAA03983.1.
PIRT09154.

3D structure databases

ProteinModelPortalO82059.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKO82059.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_SPIOL
AccessionPrimary (citable) accession number: O82059
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: June 21, 2004
Last modified: February 19, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways