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O81919

- CALR_BETVU

UniProt

O81919 - CALR_BETVU

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Protein
Calreticulin
Gene
N/A
Organism
Beta vulgaris (Sugar beet)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei115 – 1151Carbohydrate By similarity
Binding sitei117 – 1171Carbohydrate By similarity
Binding sitei134 – 1341Carbohydrate By similarity
Binding sitei141 – 1411Carbohydrate By similarity
Binding sitei324 – 3241Carbohydrate By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Calcium, Lectin, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Calreticulin
OrganismiBeta vulgaris (Sugar beet)
Taxonomic identifieri161934 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeBeta

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 416391Calreticulin
PRO_0000004188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi111 ↔ 143 By similarity
Glycosylationi157 – 1571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO81919.
SMRiO81919. Positions 211-312.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati197 – 208121-1
Add
BLAST
Repeati216 – 227121-2
Add
BLAST
Repeati233 – 244121-3
Add
BLAST
Repeati251 – 262121-4
Add
BLAST
Repeati266 – 276112-1
Add
BLAST
Repeati280 – 290112-2
Add
BLAST
Repeati294 – 304112-3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni197 – 262664 X approximate repeats
Add
BLAST
Regioni266 – 304393 X approximate repeats
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi413 – 4164Prevents secretion from ER Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi358 – 41154Asp/Glu/Lys-rich
Add
BLAST

Domaini

Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity By similarity.
The interaction with glycans occurs through a binding site in the globular lectin domain By similarity.
The zinc binding sites are localized to the N-domain By similarity.

Sequence similaritiesi

Belongs to the calreticulin family.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

PhylomeDBiO81919.

Family and domain databases

Gene3Di2.10.250.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PIRSFiPIRSF002356. Calreticulin. 1 hit.
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O81919-1 [UniParc]FASTAAdd to Basket

« Hide

MENRGRNPSF LSLLLLLSLF AIASAKVFFE ERFEDGWEKR WVKSEWKKDE    50
SMAGEWNYTS GKWNGDANDK GIQTSEDYRF YAISAEFPEF SNKDNTLVFQ 100
FSVKHEQKLD CGGGYMKLLS GEVDQKKFGG DTPYSIMFGP DICGYSTKKV 150
HAIFNYNDTN HLIKKDVPCE TDQLTHVYTF ILRPDATYSI LIDNQEKQTG 200
SLYTDWDLLP AKKIKDPEAK KPEDWDDKEF IPDPEDKKPE GYDDIPAEIT 250
DPEAKKPEDW DDEEDGEWTA PTIPNPEYKG PWKAKKIKNP NYKGKWKAPM 300
IDNPEFKDDP ELYVYPKLRY VGVELWQVKS GTLFDNVLVC DDPEYAKQLA 350
EETWGKQKDA EKAAFEELEK KREEEETKDD PVESDAEDED EAEADDSDKD 400
DADKSDDKDD DQHDEL 416
Length:416
Mass (Da):48,136
Last modified:November 1, 1998 - v1
Checksum:i565FEC3489F77CA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ002057 mRNA. Translation: CAA05161.1.
PIRiT14554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ002057 mRNA. Translation: CAA05161.1 .
PIRi T14554.

3D structure databases

ProteinModelPortali O81919.
SMRi O81919. Positions 211-312.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

PhylomeDBi O81919.

Family and domain databases

Gene3Di 2.10.250.10. 1 hit.
2.60.120.200. 1 hit.
InterProi IPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view ]
PANTHERi PTHR11073. PTHR11073. 1 hit.
Pfami PF00262. Calreticulin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002356. Calreticulin. 1 hit.
PRINTSi PR00626. CALRETICULIN.
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEi PS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence from sugar beet calreticulin."
    Viereck R.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: VV-D/ZR5.
    Tissue: Leaf.

Entry informationi

Entry nameiCALR_BETVU
AccessioniPrimary (citable) accession number: O81919
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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