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Protein

Fe(2+) transport protein 2

Gene

IRT2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity iron transporter that mediates under iron-deficiency the iron uptake from the rhizosphere across the plasma membrane in the root epidermal layer. Could also be capable of transporting zinc ions.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciARA:AT4G19680-MONOMER.
MetaCyc:AT4G19680-MONOMER.

Protein family/group databases

TCDBi2.A.5.1.4. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Fe(2+) transport protein 2
Alternative name(s):
Fe(II) transport protein 2
Iron-regulated transporter 2
Gene namesi
Name:IRT2
Ordered Locus Names:At4g19680
ORF Names:T16H5.40
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G19680.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 47ExtracellularSequence analysisAdd BLAST26
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 80CytoplasmicSequence analysisAdd BLAST12
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 120ExtracellularSequence analysisAdd BLAST19
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 195CytoplasmicSequence analysisAdd BLAST54
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 227ExtracellularSequence analysisAdd BLAST11
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 257CytoplasmicSequence analysis9
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 289ExtracellularSequence analysisAdd BLAST11
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 329CytoplasmicSequence analysisAdd BLAST19
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000004163722 – 350Fe(2+) transport protein 2Add BLAST329

Proteomic databases

PaxDbiO81850.

Expressioni

Tissue specificityi

Expressed in the external cell layers of the root subapical zone.

Inductioni

In roots by iron starvation.1 Publication

Gene expression databases

GenevisibleiO81850. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G19680.2.

Structurei

3D structure databases

ProteinModelPortaliO81850.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni208 – 209Heavy metals bindingBy similarity2

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1558. Eukaryota.
ENOG4111GP2. LUCA.
HOGENOMiHOG000157076.
InParanoidiO81850.
KOiK14709.
OMAiPCINKAK.
OrthoDBiEOG09360GCY.
PhylomeDBiO81850.

Family and domain databases

InterProiIPR003689. ZIP.
IPR004698. Zn/Fe_permease_fun/pln.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00820. zip. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O81850-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATTKLVYIL LILFTFTVSP AISTAPEHCD SGFDNPCINK AKALPLKIVA
60 70 80 90 100
IVAILTTSLI GVTSPLFSRY ISFLRPDGNG FMIVKCFSSG IILGTGFMHV
110 120 130 140 150
LPDSFEMLSS KCLSDNPWHK FPFAGFVAMM SGLVTLAIDS ITTSLYTGKN
160 170 180 190 200
SVGPVPDEEY GIDQEKAIHM VGHNHSHGHG VVLATKDDGQ LLRYQVIAMV
210 220 230 240 250
LEVGILFHSV VIGLSLGATN DSCTIKGLII ALCFHHLFEG IGLGGCILQA
260 270 280 290 300
DFTNVKKFLM AFFFTGTTPC GIFLGIALSS IYRDNSPTAL ITIGLLNACS
310 320 330 340 350
AGMLIYMALV DLLATEFMGS MLQGSIKLQI KCFTAALLGC AVMSVVAVWA
Length:350
Mass (Da):37,407
Last modified:November 1, 1998 - v1
Checksum:i66A25CA32DF1A220
GO
Isoform 2 (identifier: O81850-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-257: ADFTNVKK → VRIYIHTI
     258-350: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:257
Mass (Da):27,695
Checksum:i588506F1E9041293
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026067250 – 257ADFTNVKK → VRIYIHTI in isoform 2. 1 Publication8
Alternative sequenceiVSP_026068258 – 350Missing in isoform 2. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL024486 Genomic DNA. Translation: CAA19685.1.
AL161551 Genomic DNA. Translation: CAB78970.1.
CP002687 Genomic DNA. Translation: AEE84214.1.
CP002687 Genomic DNA. Translation: AEE84215.1.
BT020392 mRNA. Translation: AAV91338.1.
BT025714 mRNA. Translation: ABF82617.1.
PIRiT04749.
RefSeqiNP_001031670.1. NM_001036593.2. [O81850-1]
NP_193703.2. NM_118088.4. [O81850-2]
UniGeneiAt.32789.

Genome annotation databases

EnsemblPlantsiAT4G19680.2; AT4G19680.2; AT4G19680. [O81850-1]
GeneIDi827712.
GrameneiAT4G19680.2; AT4G19680.2; AT4G19680.
KEGGiath:AT4G19680.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL024486 Genomic DNA. Translation: CAA19685.1.
AL161551 Genomic DNA. Translation: CAB78970.1.
CP002687 Genomic DNA. Translation: AEE84214.1.
CP002687 Genomic DNA. Translation: AEE84215.1.
BT020392 mRNA. Translation: AAV91338.1.
BT025714 mRNA. Translation: ABF82617.1.
PIRiT04749.
RefSeqiNP_001031670.1. NM_001036593.2. [O81850-1]
NP_193703.2. NM_118088.4. [O81850-2]
UniGeneiAt.32789.

3D structure databases

ProteinModelPortaliO81850.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G19680.2.

Protein family/group databases

TCDBi2.A.5.1.4. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Proteomic databases

PaxDbiO81850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G19680.2; AT4G19680.2; AT4G19680. [O81850-1]
GeneIDi827712.
GrameneiAT4G19680.2; AT4G19680.2; AT4G19680.
KEGGiath:AT4G19680.

Organism-specific databases

TAIRiAT4G19680.

Phylogenomic databases

eggNOGiKOG1558. Eukaryota.
ENOG4111GP2. LUCA.
HOGENOMiHOG000157076.
InParanoidiO81850.
KOiK14709.
OMAiPCINKAK.
OrthoDBiEOG09360GCY.
PhylomeDBiO81850.

Enzyme and pathway databases

BioCyciARA:AT4G19680-MONOMER.
MetaCyc:AT4G19680-MONOMER.

Miscellaneous databases

PROiO81850.

Gene expression databases

GenevisibleiO81850. AT.

Family and domain databases

InterProiIPR003689. ZIP.
IPR004698. Zn/Fe_permease_fun/pln.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00820. zip. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIRT2_ARATH
AccessioniPrimary (citable) accession number: O81850
Secondary accession number(s): Q2V3G9, Q5M756
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.