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Protein

Probable histone H2A.3

Gene

At4g27230

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histone H2A.3
Alternative name(s):
HTA2
Gene namesi
Ordered Locus Names:At4g27230
ORF Names:M4I22.40
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G27230.
TAIRilocus:2131704. AT4G27230.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000552011 – 131Probable histone H2A.3Add BLAST131

Post-translational modificationi

Not ubiquitinated.

Proteomic databases

PaxDbiO81826.
PRIDEiO81826.

Expressioni

Tissue specificityi

Expressed in meristems and dividing cells.1 Publication

Gene expression databases

ExpressionAtlasiO81826. baseline and differential.
GenevisibleiO81826. AT.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi14118. 3 interactors.
IntActiO81826. 4 interactors.
STRINGi3702.AT4G27230.1.

Structurei

3D structure databases

ProteinModelPortaliO81826.
SMRiO81826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1756. Eukaryota.
COG5262. LUCA.
HOGENOMiHOG000234652.
InParanoidiO81826.
KOiK11251.
OMAiHLAGWEA.
OrthoDBiEOG09360WU4.
PhylomeDBiO81826.

Family and domain databases

CDDicd00074. H2A. 1 hit.
InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
PRINTSiPR00620. HISTONEH2A.
SMARTiView protein in SMART
SM00414. H2A. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00046. HISTONE_H2A. 1 hit.

Sequencei

Sequence statusi: Complete.

O81826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGKQLGS GAAKKSTSRS SKAGLQFPVG RIARFLKAGK YAERVGAGAP
60 70 80 90 100
VYLAAVLEYL AAEVLELAGN AARDNKKTRI VPRHIQLAVR NDEELSKLLG
110 120 130
DVTIANGGVM PNIHNLLLPK KAGSSKPTEE D
Length:131
Mass (Da):13,833
Last modified:November 1, 1998 - v1
Checksum:i293B0F91F5141855
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100G → E in AAM67032 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL030978 Genomic DNA. Translation: CAA19717.1.
AL161566 Genomic DNA. Translation: CAB79578.1.
CP002687 Genomic DNA. Translation: AEE85313.1.
CP002687 Genomic DNA. Translation: AEE85314.1.
BT005779 mRNA. Translation: AAO64183.1.
BT006076 mRNA. Translation: AAP04061.1.
AY088714 mRNA. Translation: AAM67032.1.
PIRiT05747.
RefSeqiNP_001190852.1. NM_001203923.1.
NP_194453.1. NM_118857.4.
UniGeneiAt.2335.

Genome annotation databases

EnsemblPlantsiAT4G27230.1; AT4G27230.1; AT4G27230.
AT4G27230.2; AT4G27230.2; AT4G27230.
GeneIDi828831.
GrameneiAT4G27230.1; AT4G27230.1; AT4G27230.
AT4G27230.2; AT4G27230.2; AT4G27230.
KEGGiath:AT4G27230.

Similar proteinsi

Entry informationi

Entry nameiH2A3_ARATH
AccessioniPrimary (citable) accession number: O81826
Secondary accession number(s): Q8L8Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: November 1, 1998
Last modified: October 25, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families