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Protein

Heat stress transcription factor A-1b

Gene

HSFA1B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi25 – 119By similarityAdd BLAST95

GO - Molecular functioni

  • DNA binding Source: TAIR
  • DNA binding transcription factor activity Source: TAIR
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • response to heat Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processStress response, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-ATH-3371453 Regulation of HSF1-mediated heat shock response
R-ATH-3371511 HSF1 activation
R-ATH-3371568 Attenuation phase
R-ATH-3371571 HSF1-dependent transactivation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat stress transcription factor A-1b
Short name:
AtHsfA1b
Alternative name(s):
AtHsf-18
Heat shock factor protein 3
Short name:
HSF 3
Heat shock transcription factor 3
Short name:
HSTF 3
Gene namesi
Name:HSFA1B
Synonyms:HSF18, HSF3
Ordered Locus Names:At5g16820
ORF Names:F5E19.160
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G16820
TAIRilocus:2149050 AT5G16820

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001245841 – 481Heat stress transcription factor A-1bAdd BLAST481

Post-translational modificationi

Exhibits temperature-dependent phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO81821
PRIDEiO81821

PTM databases

iPTMnetiO81821

Expressioni

Gene expression databases

ExpressionAtlasiO81821 baseline and differential
GenevisibleiO81821 AT

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi16821, 4 interactors
IntActiO81821, 1 interactor
STRINGi3702.AT5G16820.1

Structurei

3D structure databases

ProteinModelPortaliO81821
SMRiO81821
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 204Hydrophobic repeat HR-A/BAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi229 – 233Nuclear localization signalSequence analysis5
Motifi418 – 427AHA10
Motifi467 – 474Nuclear export signalSequence analysis8

Domaini

The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain. AHA motif is a transcriptional activator element.1 Publication

Sequence similaritiesi

Belongs to the HSF family. Class A subfamily.Curated

Phylogenomic databases

eggNOGiKOG0627 Eukaryota
COG5169 LUCA
HOGENOMiHOG000237979
InParanoidiO81821
KOiK09419
OMAiELREWTR
OrthoDBiEOG09360JWU
PhylomeDBiO81821

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000232 HSF_DNA-bd
IPR027725 HSF_fam
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10015 PTHR10015, 1 hit
PfamiView protein in Pfam
PF00447 HSF_DNA-bind, 1 hit
PRINTSiPR00056 HSFDOMAIN
SMARTiView protein in SMART
SM00415 HSF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00434 HSF_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

O81821-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVPESVPS PNSNTPSIPP PVNSVPPFLS KTYDMVDDPL TNEVVSWSSG
60 70 80 90 100
NNSFVVWSAP EFSKVLLPKY FKHNNFSSFV RQLNTYGFRK VDPDRWEFAN
110 120 130 140 150
EGFLRGRKQL LKSIVRRKPS HVQQNQQQTQ VQSSSVGACV EVGKFGIEEE
160 170 180 190 200
VERLKRDKNV LMQELVRLRQ QQQATENQLQ NVGQKVQVME QRQQQMMSFL
210 220 230 240 250
AKAVQSPGFL NQLVQQNNND GNRQIPGSNK KRRLPVDEQE NRGDNVANGL
260 270 280 290 300
NRQIVRYQPS INEAAQNMLR QFLNTSTSPR YESVSNNPDS FLLGDVPSST
310 320 330 340 350
SVDNGNPSSR VSGVTLAEFS PNTVQSATNQ VPEASLAHHP QAGLVQPNIG
360 370 380 390 400
QSPAQGAAPA DSWSPEFDLV GCETDSGECF DPIMAVLDES EGDAISPEGE
410 420 430 440 450
GKMNELLEGV PKLPGIQDPF WEQFFSVELP AIADTDDILS GSVENNDLVL
460 470 480
EQEPNEWTRN EQQMKYLTEQ MGLLSSEAQR K
Length:481
Mass (Da):53,576
Last modified:December 1, 2000 - v2
Checksum:iB0BEAD9E184358C1
GO

Sequence cautioni

The sequence CAC01846 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14068 mRNA Translation: CAA74397.1
AL391147 Genomic DNA Translation: CAC01846.1 Different initiation.
CP002688 Genomic DNA Translation: AED92343.1
CP002688 Genomic DNA Translation: AED92344.1
PIRiT51514
T51945
RefSeqiNP_197184.2, NM_121688.4
NP_850832.1, NM_180501.3
UniGeneiAt.1639
At.5364

Genome annotation databases

EnsemblPlantsiAT5G16820.1; AT5G16820.1; AT5G16820
AT5G16820.2; AT5G16820.2; AT5G16820
GeneIDi831545
GrameneiAT5G16820.1; AT5G16820.1; AT5G16820
AT5G16820.2; AT5G16820.2; AT5G16820
KEGGiath:AT5G16820

Similar proteinsi

Entry informationi

Entry nameiHFA1B_ARATH
AccessioniPrimary (citable) accession number: O81821
Secondary accession number(s): Q9LFD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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