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Protein

Heat stress transcription factor A-1b

Gene

HSFA1B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi25 – 119By similarityAdd BLAST95

GO - Molecular functioni

  • DNA binding Source: TAIR
  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • response to heat Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-ATH-3371453. Regulation of HSF1-mediated heat shock response.
R-ATH-3371511. HSF1 activation.
R-ATH-3371568. Attenuation phase.
R-ATH-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat stress transcription factor A-1b
Short name:
AtHsfA1b
Alternative name(s):
AtHsf-18
Heat shock factor protein 3
Short name:
HSF 3
Heat shock transcription factor 3
Short name:
HSTF 3
Gene namesi
Name:HSFA1B
Synonyms:HSF18, HSF3
Ordered Locus Names:At5g16820
ORF Names:F5E19.160
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G16820.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001245841 – 481Heat stress transcription factor A-1bAdd BLAST481

Post-translational modificationi

Exhibits temperature-dependent phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO81821.

PTM databases

iPTMnetiO81821.

Expressioni

Gene expression databases

GenevisibleiO81821. AT.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi16821. 4 interactors.
STRINGi3702.AT5G16820.1.

Structurei

3D structure databases

ProteinModelPortaliO81821.
SMRiO81821.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 204Hydrophobic repeat HR-A/BAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi229 – 233Nuclear localization signalSequence analysis5
Motifi418 – 427AHA10
Motifi467 – 474Nuclear export signalSequence analysis8

Domaini

The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain. AHA motif is a transcriptional activator element.1 Publication

Sequence similaritiesi

Belongs to the HSF family. Class A subfamily.Curated

Phylogenomic databases

eggNOGiKOG0627. Eukaryota.
COG5169. LUCA.
HOGENOMiHOG000237979.
InParanoidiO81821.
KOiK09419.
OMAiAINDIFW.
OrthoDBiEOG09360JWU.
PhylomeDBiO81821.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 2 hits.
PfamiPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
PRINTSiPR00056. HSFDOMAIN.
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00434. HSF_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O81821-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVPESVPS PNSNTPSIPP PVNSVPPFLS KTYDMVDDPL TNEVVSWSSG
60 70 80 90 100
NNSFVVWSAP EFSKVLLPKY FKHNNFSSFV RQLNTYGFRK VDPDRWEFAN
110 120 130 140 150
EGFLRGRKQL LKSIVRRKPS HVQQNQQQTQ VQSSSVGACV EVGKFGIEEE
160 170 180 190 200
VERLKRDKNV LMQELVRLRQ QQQATENQLQ NVGQKVQVME QRQQQMMSFL
210 220 230 240 250
AKAVQSPGFL NQLVQQNNND GNRQIPGSNK KRRLPVDEQE NRGDNVANGL
260 270 280 290 300
NRQIVRYQPS INEAAQNMLR QFLNTSTSPR YESVSNNPDS FLLGDVPSST
310 320 330 340 350
SVDNGNPSSR VSGVTLAEFS PNTVQSATNQ VPEASLAHHP QAGLVQPNIG
360 370 380 390 400
QSPAQGAAPA DSWSPEFDLV GCETDSGECF DPIMAVLDES EGDAISPEGE
410 420 430 440 450
GKMNELLEGV PKLPGIQDPF WEQFFSVELP AIADTDDILS GSVENNDLVL
460 470 480
EQEPNEWTRN EQQMKYLTEQ MGLLSSEAQR K
Length:481
Mass (Da):53,576
Last modified:December 1, 2000 - v2
Checksum:iB0BEAD9E184358C1
GO

Sequence cautioni

The sequence CAC01846 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14068 mRNA. Translation: CAA74397.1.
AL391147 Genomic DNA. Translation: CAC01846.1. Different initiation.
CP002688 Genomic DNA. Translation: AED92343.1.
CP002688 Genomic DNA. Translation: AED92344.1.
PIRiT51514.
T51945.
RefSeqiNP_197184.2. NM_121688.4.
NP_850832.1. NM_180501.3.
UniGeneiAt.1639.
At.5364.

Genome annotation databases

EnsemblPlantsiAT5G16820.1; AT5G16820.1; AT5G16820.
AT5G16820.2; AT5G16820.2; AT5G16820.
GeneIDi831545.
GrameneiAT5G16820.1; AT5G16820.1; AT5G16820.
AT5G16820.2; AT5G16820.2; AT5G16820.
KEGGiath:AT5G16820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14068 mRNA. Translation: CAA74397.1.
AL391147 Genomic DNA. Translation: CAC01846.1. Different initiation.
CP002688 Genomic DNA. Translation: AED92343.1.
CP002688 Genomic DNA. Translation: AED92344.1.
PIRiT51514.
T51945.
RefSeqiNP_197184.2. NM_121688.4.
NP_850832.1. NM_180501.3.
UniGeneiAt.1639.
At.5364.

3D structure databases

ProteinModelPortaliO81821.
SMRiO81821.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16821. 4 interactors.
STRINGi3702.AT5G16820.1.

PTM databases

iPTMnetiO81821.

Proteomic databases

PaxDbiO81821.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G16820.1; AT5G16820.1; AT5G16820.
AT5G16820.2; AT5G16820.2; AT5G16820.
GeneIDi831545.
GrameneiAT5G16820.1; AT5G16820.1; AT5G16820.
AT5G16820.2; AT5G16820.2; AT5G16820.
KEGGiath:AT5G16820.

Organism-specific databases

TAIRiAT5G16820.

Phylogenomic databases

eggNOGiKOG0627. Eukaryota.
COG5169. LUCA.
HOGENOMiHOG000237979.
InParanoidiO81821.
KOiK09419.
OMAiAINDIFW.
OrthoDBiEOG09360JWU.
PhylomeDBiO81821.

Enzyme and pathway databases

ReactomeiR-ATH-3371453. Regulation of HSF1-mediated heat shock response.
R-ATH-3371511. HSF1 activation.
R-ATH-3371568. Attenuation phase.
R-ATH-3371571. HSF1-dependent transactivation.

Miscellaneous databases

PROiO81821.

Gene expression databases

GenevisibleiO81821. AT.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 2 hits.
PfamiPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
PRINTSiPR00056. HSFDOMAIN.
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00434. HSF_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHFA1B_ARATH
AccessioniPrimary (citable) accession number: O81821
Secondary accession number(s): Q9LFD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.