Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxidase 46

Gene

PER46

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei65Transition state stabilizerPROSITE-ProRule annotation1
Active sitei69Proton acceptorPROSITE-ProRule annotation1
Metal bindingi70Calcium 1PROSITE-ProRule annotation1
Metal bindingi73Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi75Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi77Calcium 1PROSITE-ProRule annotation1
Metal bindingi79Calcium 1PROSITE-ProRule annotation1
Metal bindingi192Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi193Calcium 2PROSITE-ProRule annotation1
Metal bindingi246Calcium 2PROSITE-ProRule annotation1
Metal bindingi249Calcium 2PROSITE-ProRule annotation1
Metal bindingi254Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G31760-MONOMER.

Protein family/group databases

PeroxiBasei212. AtPrx46.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 46 (EC:1.11.1.7)
Short name:
Atperox P46
Alternative name(s):
ATP48
Gene namesi
Name:PER46
Synonyms:P46
Ordered Locus Names:At4g31760
ORF Names:F28M20.50
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G31760.

Subcellular locationi

  • Secreted PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000002371228 – 326Peroxidase 46Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi38 ↔ 114PROSITE-ProRule annotation
Disulfide bondi71 ↔ 76PROSITE-ProRule annotation
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi120 ↔ 322PROSITE-ProRule annotation
Disulfide bondi199 ↔ 233PROSITE-ProRule annotation
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO81772.

Expressioni

Gene expression databases

GenevisibleiO81772. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G31760.1.

Structurei

3D structure databases

ProteinModelPortaliO81772.
SMRiO81772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE9G. Eukaryota.
ENOG410Y94T. LUCA.
HOGENOMiHOG000237556.
InParanoidiO81772.
KOiK00430.
OrthoDBiEOG09360JGY.
PhylomeDBiO81772.

Family and domain databases

CDDicd00693. secretory_peroxidase. 1 hit.
InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019793. Peroxidases_heam-ligand_BS.
IPR033905. Secretory_peroxidase.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O81772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSYRINCS TLLHLLMFLS SLLTSSANLS FNFYASSCSV AEFLVRNTVR
60 70 80 90 100
SATSSDPTIP GKLLRLFFHD CFVQGCDASV LIQGNSTEKS DPGNASLGGF
110 120 130 140 150
SVIDTAKNAI ENLCPATVSC ADIVALAARD AVEAAGGPVV EIPTGRRDGK
160 170 180 190 200
ESMAANVRPN IIDTDFTLDQ MIDAFSSKGL SIQDLVVLSG AHTIGASHCN
210 220 230 240 250
AFNGRFQRDS KGNFEVIDAS LDNSYAETLM NKCSSSESSS LTVSNDPETS
260 270 280 290 300
AVFDNQYYRN LETHKGLFQT DSALMEDNRT RTMVEELASD EESFFQRWSE
310 320
SFVKLSMVGV RVGEDGEIRR SCSSVN
Length:326
Mass (Da):35,244
Last modified:November 1, 1998 - v1
Checksum:i1FC9CA566895967B
GO

Sequence cautioni

The sequence AEE85954 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031004 Genomic DNA. Translation: CAA19747.1.
AL161579 Genomic DNA. Translation: CAB79894.1.
CP002687 Genomic DNA. Translation: AEE85954.1. Sequence problems.
PIRiT05094.
RefSeqiNP_194904.3. NM_119325.3.

Genome annotation databases

EnsemblPlantsiAT4G31760.1; AT4G31760.1; AT4G31760.
GeneIDi829304.
GrameneiAT4G31760.1; AT4G31760.1; AT4G31760.
KEGGiath:AT4G31760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031004 Genomic DNA. Translation: CAA19747.1.
AL161579 Genomic DNA. Translation: CAB79894.1.
CP002687 Genomic DNA. Translation: AEE85954.1. Sequence problems.
PIRiT05094.
RefSeqiNP_194904.3. NM_119325.3.

3D structure databases

ProteinModelPortaliO81772.
SMRiO81772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G31760.1.

Protein family/group databases

PeroxiBasei212. AtPrx46.

Proteomic databases

PaxDbiO81772.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G31760.1; AT4G31760.1; AT4G31760.
GeneIDi829304.
GrameneiAT4G31760.1; AT4G31760.1; AT4G31760.
KEGGiath:AT4G31760.

Organism-specific databases

TAIRiAT4G31760.

Phylogenomic databases

eggNOGiENOG410IE9G. Eukaryota.
ENOG410Y94T. LUCA.
HOGENOMiHOG000237556.
InParanoidiO81772.
KOiK00430.
OrthoDBiEOG09360JGY.
PhylomeDBiO81772.

Enzyme and pathway databases

BioCyciARA:AT4G31760-MONOMER.

Miscellaneous databases

PROiO81772.

Gene expression databases

GenevisibleiO81772. AT.

Family and domain databases

CDDicd00693. secretory_peroxidase. 1 hit.
InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019793. Peroxidases_heam-ligand_BS.
IPR033905. Secretory_peroxidase.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPER46_ARATH
AccessioniPrimary (citable) accession number: O81772
Secondary accession number(s): F4JSS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.