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Protein

Putative Peroxidase 48

Gene

PER48

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei104Transition state stabilizerPROSITE-ProRule annotation1
Active sitei108Proton acceptorPROSITE-ProRule annotation1
Metal bindingi109Calcium 1PROSITE-ProRule annotation1
Metal bindingi112Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi114Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi116Calcium 1PROSITE-ProRule annotation1
Metal bindingi118Calcium 1PROSITE-ProRule annotation1
Binding sitei204Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi234Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi235Calcium 2PROSITE-ProRule annotation1
Metal bindingi287Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G33870-MONOMER.

Protein family/group databases

PeroxiBasei214. AtPrx48.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Peroxidase 48 (EC:1.11.1.7)
Short name:
Atperox P48
Gene namesi
Name:PER48
Synonyms:P48
Ordered Locus Names:At4g33870
ORF Names:F17I5.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G33870.

Subcellular locationi

  • Secreted PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000005560019 – 404Putative Peroxidase 48Add BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi77 ↔ 156PROSITE-ProRule annotation
Disulfide bondi110 ↔ 115PROSITE-ProRule annotation
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi162 ↔ 397PROSITE-ProRule annotation
Disulfide bondi241 ↔ 273PROSITE-ProRule annotation
Glycosylationi250N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO81755.

Expressioni

Gene expression databases

GenevisibleiO81755. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G33870.1.

Structurei

3D structure databases

ProteinModelPortaliO81755.
SMRiO81755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIQW. Eukaryota.
ENOG410YD1D. LUCA.
HOGENOMiHOG000237556.
InParanoidiO81755.
KOiK00430.
OrthoDBiEOG09360FQE.

Family and domain databases

CDDicd00693. secretory_peroxidase. 1 hit.
InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR033905. Secretory_peroxidase.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O81755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFLGDYKFA LLTCSVIALS IYFAINVEFR FAYDSPGTRT GVKVSEKSPF
60 70 80 90 100
DDEFMYMSIA EDIDRSYLHY DYYRESCPTA EKIIAKAIRD IYNVTPSVAP
110 120 130 140 150
PIIRLLFHDC FIEGCDASVL LDADEAHTSE KDASPNLSLK GFDVIDAVKS
160 170 180 190 200
ELENVCPGVV SCADLLVLAA REAVLVAGGP FYPLETGRKD SAAAYRDFAE
210 220 230 240 250
HELPAPDATL SVILQRFSFR GFNERETVSL FGAHSIGITH CTFFKNRLYN
260 270 280 290 300
FSATGKPDPE LNPGFLQELK TKCPFSVSTS SPSAPPDIGL PPSLPASDSE
310 320 330 340 350
NSYGMSSGNR NDEVIDLSYN NEGGDENFGT RYFRRLMQNK GLMSSDQQLM
360 370 380 390 400
GSEVTEMWVR AYASDPLLFR REFAMSMMKL SSYNVLTGPL GQVRTSCSKA

LPRN
Length:404
Mass (Da):44,792
Last modified:September 22, 2009 - v3
Checksum:i207F25B54317FBE8
GO

Sequence cautioni

The sequence AEE86286 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA19869 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80104 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031032 Genomic DNA. Translation: CAA19869.1. Sequence problems.
AL161584 Genomic DNA. Translation: CAB80104.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE86286.1. Sequence problems.

Genome annotation databases

EnsemblPlantsiAT4G33870.1; AT4G33870.1; AT4G33870.
GrameneiAT4G33870.1; AT4G33870.1; AT4G33870.
KEGGiath:AT4G33870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031032 Genomic DNA. Translation: CAA19869.1. Sequence problems.
AL161584 Genomic DNA. Translation: CAB80104.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE86286.1. Sequence problems.

3D structure databases

ProteinModelPortaliO81755.
SMRiO81755.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G33870.1.

Protein family/group databases

PeroxiBasei214. AtPrx48.

Proteomic databases

PaxDbiO81755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G33870.1; AT4G33870.1; AT4G33870.
GrameneiAT4G33870.1; AT4G33870.1; AT4G33870.
KEGGiath:AT4G33870.

Organism-specific databases

TAIRiAT4G33870.

Phylogenomic databases

eggNOGiENOG410IIQW. Eukaryota.
ENOG410YD1D. LUCA.
HOGENOMiHOG000237556.
InParanoidiO81755.
KOiK00430.
OrthoDBiEOG09360FQE.

Enzyme and pathway databases

BioCyciARA:AT4G33870-MONOMER.

Miscellaneous databases

PROiO81755.

Gene expression databases

GenevisibleiO81755. AT.

Family and domain databases

CDDicd00693. secretory_peroxidase. 1 hit.
InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR033905. Secretory_peroxidase.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPER48_ARATH
AccessioniPrimary (citable) accession number: O81755
Secondary accession number(s): F4JJV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: September 22, 2009
Last modified: November 30, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.