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Protein

Putative Peroxidase 48

Gene

PER48

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei104Transition state stabilizerPROSITE-ProRule annotation1
Active sitei108Proton acceptorPROSITE-ProRule annotation1
Metal bindingi109Calcium 1PROSITE-ProRule annotation1
Metal bindingi112Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi114Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi116Calcium 1PROSITE-ProRule annotation1
Metal bindingi118Calcium 1PROSITE-ProRule annotation1
Binding sitei204Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi234Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi235Calcium 2PROSITE-ProRule annotation1
Metal bindingi287Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G33870-MONOMER

Protein family/group databases

PeroxiBasei214 AtPrx48

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Peroxidase 48 (EC:1.11.1.7)
Short name:
Atperox P48
Gene namesi
Name:PER48
Synonyms:P48
Ordered Locus Names:At4g33870
ORF Names:F17I5.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G33870

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000005560019 – 404Putative Peroxidase 48Add BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi77 ↔ 156PROSITE-ProRule annotation
Disulfide bondi110 ↔ 115PROSITE-ProRule annotation
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi162 ↔ 397PROSITE-ProRule annotation
Disulfide bondi241 ↔ 273PROSITE-ProRule annotation
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO81755

Expressioni

Gene expression databases

ExpressionAtlasiO81755 baseline and differential
GenevisibleiO81755 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G33870.1

Structurei

3D structure databases

ProteinModelPortaliO81755
SMRiO81755
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIQW Eukaryota
ENOG410YD1D LUCA
HOGENOMiHOG000237556
InParanoidiO81755
KOiK00430
OrthoDBiEOG09360FQE

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
PROSITEiView protein in PROSITE
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O81755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFLGDYKFA LLTCSVIALS IYFAINVEFR FAYDSPGTRT GVKVSEKSPF
60 70 80 90 100
DDEFMYMSIA EDIDRSYLHY DYYRESCPTA EKIIAKAIRD IYNVTPSVAP
110 120 130 140 150
PIIRLLFHDC FIEGCDASVL LDADEAHTSE KDASPNLSLK GFDVIDAVKS
160 170 180 190 200
ELENVCPGVV SCADLLVLAA REAVLVAGGP FYPLETGRKD SAAAYRDFAE
210 220 230 240 250
HELPAPDATL SVILQRFSFR GFNERETVSL FGAHSIGITH CTFFKNRLYN
260 270 280 290 300
FSATGKPDPE LNPGFLQELK TKCPFSVSTS SPSAPPDIGL PPSLPASDSE
310 320 330 340 350
NSYGMSSGNR NDEVIDLSYN NEGGDENFGT RYFRRLMQNK GLMSSDQQLM
360 370 380 390 400
GSEVTEMWVR AYASDPLLFR REFAMSMMKL SSYNVLTGPL GQVRTSCSKA

LPRN
Length:404
Mass (Da):44,792
Last modified:September 22, 2009 - v3
Checksum:i207F25B54317FBE8
GO

Sequence cautioni

The sequence CAA19869 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80104 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031032 Genomic DNA Translation: CAA19869.1 Sequence problems.
AL161584 Genomic DNA Translation: CAB80104.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE86286.2
RefSeqiNP_001320128.1, NM_001342239.1

Genome annotation databases

EnsemblPlantsiAT4G33870.1; AT4G33870.1; AT4G33870
GeneIDi829530
GrameneiAT4G33870.1; AT4G33870.1; AT4G33870
KEGGiath:AT4G33870

Similar proteinsi

Entry informationi

Entry nameiPER48_ARATH
AccessioniPrimary (citable) accession number: O81755
Secondary accession number(s): F4JJV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: September 22, 2009
Last modified: April 25, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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