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O81716

- P2C21_ARATH

UniProt

O81716 - P2C21_ARATH

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Protein

Probable protein phosphatase 2C 21

Gene

PPC4-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Manganese 1By similarity
Metal bindingi57 – 571Manganese 2By similarity
Metal bindingi58 – 581Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi272 – 2721Manganese 2By similarity
Metal bindingi320 – 3201Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
  2. response to abscisic acid Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G25070-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 21 (EC:3.1.3.16)
Short name:
AtPP2C21
Alternative name(s):
AtPPC4;2
Gene namesi
Name:PPC4-2
Ordered Locus Names:At2g25070
ORF Names:F13D4.1, F27C12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G25070.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Probable protein phosphatase 2C 21PRO_0000367951Add
BLAST

Proteomic databases

PaxDbiO81716.
PRIDEiO81716.

Expressioni

Gene expression databases

GenevestigatoriO81716.

Interactioni

Protein-protein interaction databases

BioGridi2397. 1 interaction.
IntActiO81716. 1 interaction.
MINTiMINT-8390663.
STRINGi3702.AT2G25070.1-P.

Structurei

3D structure databases

ProteinModelPortaliO81716.
SMRiO81716. Positions 1-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 322301PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiO81716.
KOiK17499.
OMAiDPDINTI.
PhylomeDBiO81716.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O81716-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTYLSSPKT EKLSEDGEND KLRFGLSSMQ GWRATMEDAH AAILDLDDKT
60 70 80 90 100
SFFGVYDGHG GKVVAKFCAK YLHQQVISNE AYKTGDVETS LRRAFFRMDD
110 120 130 140 150
MMQGQRGWRE LAVLGDKMNK FSGMIEGFIW SPRSGDTNNQ PDSWPLEDGP
160 170 180 190 200
HSDFTGPTSG CTACVALIKD KKLFVANAGD SRCVISRKSQ AYNLSKDHKP
210 220 230 240 250
DLEVEKERIL KAGGFIHAGR INGSLNLTRA IGDMEFKQNK FLPSEKQMVT
260 270 280 290 300
ADPDINTIDL CDDDDFLVVA CDGIWDCMSS QELVDFIHEQ LKSETKLSTV
310 320 330 340 350
CEKVVDRCLA PDTATGEGCD NMTIILVQFK KPNPSETEPE DSKPEPSEDE

PSSSS
Length:355
Mass (Da):39,354
Last modified:November 1, 1998 - v1
Checksum:iCAD638796203C746
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079671 mRNA. Translation: BAB84700.1.
AC006585 Genomic DNA. Translation: AAD23006.1.
CP002685 Genomic DNA. Translation: AEC07654.1.
AY050873 mRNA. Translation: AAK92810.1.
AY091209 mRNA. Translation: AAM14148.1.
PIRiH84643.
RefSeqiNP_180079.1. NM_128064.2.
UniGeneiAt.24404.

Genome annotation databases

EnsemblPlantsiAT2G25070.1; AT2G25070.1; AT2G25070.
GeneIDi817045.
KEGGiath:AT2G25070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079671 mRNA. Translation: BAB84700.1 .
AC006585 Genomic DNA. Translation: AAD23006.1 .
CP002685 Genomic DNA. Translation: AEC07654.1 .
AY050873 mRNA. Translation: AAK92810.1 .
AY091209 mRNA. Translation: AAM14148.1 .
PIRi H84643.
RefSeqi NP_180079.1. NM_128064.2.
UniGenei At.24404.

3D structure databases

ProteinModelPortali O81716.
SMRi O81716. Positions 1-330.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 2397. 1 interaction.
IntActi O81716. 1 interaction.
MINTi MINT-8390663.
STRINGi 3702.AT2G25070.1-P.

Proteomic databases

PaxDbi O81716.
PRIDEi O81716.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G25070.1 ; AT2G25070.1 ; AT2G25070 .
GeneIDi 817045.
KEGGi ath:AT2G25070.

Organism-specific databases

TAIRi AT2G25070.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233896.
InParanoidi O81716.
KOi K17499.
OMAi DPDINTI.
PhylomeDBi O81716.

Enzyme and pathway databases

BioCyci ARA:AT2G25070-MONOMER.

Miscellaneous databases

PROi O81716.

Gene expression databases

Genevestigatori O81716.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 2 hits.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 2 hits.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Substrate specificity of type 2C protein phosphatases (PP2C) in Arabidopsis thaliana."
    Izumi S., Yamada M., Ohsato H., Miyazaki S., Bohnert H.J., Fukuhara T.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  6. "Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
    Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
    Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiP2C21_ARATH
AccessioniPrimary (citable) accession number: O81716
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 1, 1998
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3