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O81701 (POLC4_ALNGL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polcalcin Aln g 4
Alternative name(s):
Calcium-binding pollen allergen Aln g 4
Allergen=Aln g 4
OrganismAlnus glutinosa (European alder) (Betula alnus var. glutinosa)
Taxonomic identifier3517 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeAlnus

Protein attributes

Sequence length85 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Contains 2 EF-hand domains.

Mass spectrometry

Molecular mass is 9318.6 Da from positions 1 - 85. Determined by MALDI. Ref.1

Ontologies

Keywords
   DiseaseAllergen
   DomainRepeat
   LigandCalcium
Metal-binding
Gene Ontology (GO)
   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8585Polcalcin Aln g 4
PRO_0000073663

Regions

Domain7 – 4236EF-hand 1
Domain42 – 7736EF-hand 2
Calcium binding20 – 31121 Potential
Calcium binding55 – 66122 Potential

Sequences

Sequence LengthMass (Da)Tools
O81701 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 903774CC1F714FAD

FASTA859,362
        10         20         30         40         50         60 
MADDHPQDQA EHERIFKCFD ANGDGKISAS ELGDALKTLG SVTPDEVKHM MAEIDTDGDG 

        70         80 
FISFQEFTNF ARANRGLVKD VAKIF 

« Hide

References

[1]"Molecular and immunologic characterization of a highly cross-reactive two EF-hand calcium-binding alder pollen allergen, Aln g 4: structural basis for calcium-modulated IgE recognition."
Hayek B., Vangelista L., Pastore A., Sperr W.R., Valent P., Vrtala S., Niederberger V., Twardosz A., Kraft D., Valenta R.
J. Immunol. 161:7031-7039(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, MASS SPECTROMETRY.
Tissue: Pollen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y17713 mRNA. Translation: CAA76831.1.

3D structure databases

ProteinModelPortalO81701.
SMRO81701. Positions 2-85.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3056. Aln g 4.0101.
9. Aln g 4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePOLC4_ALNGL
AccessionPrimary (citable) accession number: O81701
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries