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O81701

- POLC4_ALNGL

UniProt

O81701 - POLC4_ALNGL

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Protein

Polcalcin Aln g 4

Gene
N/A
Organism
Alnus glutinosa (European alder) (Betula alnus var. glutinosa)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 31121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi55 – 66122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polcalcin Aln g 4
Alternative name(s):
Calcium-binding pollen allergen Aln g 4
Allergen: Aln g 4
OrganismiAlnus glutinosa (European alder) (Betula alnus var. glutinosa)
Taxonomic identifieri3517 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeAlnus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3056. Aln g 4.0101.
9. Aln g 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8585Polcalcin Aln g 4PRO_0000073663Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO81701.
SMRiO81701. Positions 2-85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 4236EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini42 – 7736EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O81701-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADDHPQDQA EHERIFKCFD ANGDGKISAS ELGDALKTLG SVTPDEVKHM
60 70 80
MAEIDTDGDG FISFQEFTNF ARANRGLVKD VAKIF
Length:85
Mass (Da):9,362
Last modified:November 1, 1998 - v1
Checksum:i903774CC1F714FAD
GO

Mass spectrometryi

Molecular mass is 9318.6 Da from positions 1 - 85. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y17713 mRNA. Translation: CAA76831.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y17713 mRNA. Translation: CAA76831.1 .

3D structure databases

ProteinModelPortali O81701.
SMRi O81701. Positions 2-85.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 3056. Aln g 4.0101.
9. Aln g 4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular and immunologic characterization of a highly cross-reactive two EF-hand calcium-binding alder pollen allergen, Aln g 4: structural basis for calcium-modulated IgE recognition."
    Hayek B., Vangelista L., Pastore A., Sperr W.R., Valent P., Vrtala S., Niederberger V., Twardosz A., Kraft D., Valenta R.
    J. Immunol. 161:7031-7039(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, MASS SPECTROMETRY.
    Tissue: Pollen.

Entry informationi

Entry nameiPOLC4_ALNGL
AccessioniPrimary (citable) accession number: O81701
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3