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Protein

Villin-1

Gene

VLN1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds actin and actin filament bundles in a Ca2+/calmodulin-insensitive manner, but is unable to sever, cap, and nucleate actin filament formation in vitro. Does not protect individual filaments from severing by VLN3 (AC O81645).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin capping, Actin-binding
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Villin-11 Publication
Gene namesi
Name:VLN11 Publication
Ordered Locus Names:At2g29890Imported
ORF Names:F6K5.2Imported, T27A16.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G29890

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187321 – 909Villin-1Add BLAST909

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei780PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO81643
PRIDEiO81643

PTM databases

iPTMnetiO81643

Expressioni

Tissue specificityi

Expressed in all tissues examined. Mainly detected in the vascular tissue and the pericycle of roots and in the vasculature of leaves. Not expressed in the root cap.2 Publications

Gene expression databases

ExpressionAtlasiO81643 baseline and differential
GenevisibleiO81643 AT

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2889, 1 interactor
STRINGi3702.AT2G29890.3

Structurei

3D structure databases

ProteinModelPortaliO81643
SMRiO81643
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 79Gelsolin-like 1Sequence analysisAdd BLAST51
Repeati149 – 189Gelsolin-like 2Sequence analysisAdd BLAST41
Repeati262 – 305Gelsolin-like 3Sequence analysisAdd BLAST44
Repeati391 – 448Gelsolin-like 4Sequence analysisAdd BLAST58
Repeati529 – 569Gelsolin-like 5Sequence analysisAdd BLAST41
Repeati631 – 672Gelsolin-like 6Sequence analysisAdd BLAST42
Domaini844 – 909HPPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0443 Eukaryota
ENOG410XR0A LUCA
HOGENOMiHOG000233631
InParanoidiO81643
PhylomeDBiO81643

Family and domain databases

Gene3Di1.10.950.10, 1 hit
3.40.20.10, 6 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR030010 Villin-1-like_plant
IPR007122 Villin/Gelsolin
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF25 PTHR11977:SF25, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 4 hits
PF02209 VHP, 1 hit
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 6 hits
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: O81643-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRLSKDIDS AFQGVGTKSG LEIWCVYNKQ LISIPKSSFG KFHSGNAYLV
60 70 80 90 100
LRTFLRKIES PQYDIHYWLG IDANEVDSIL ASDKALDLDA ALGCCTVQYR
110 120 130 140 150
EVQGQETEKF LSYFKPCIIP VEGKYSPKTG IAGETYQVTL LRCKGDHVVR
160 170 180 190 200
VKEVPFLRSS LNHDDVFILD TASKVFLFAG CNSSTQEKAK AMEVVEYIKD
210 220 230 240 250
NKHDGRCEVA TIEDGKFSGD SDAGEFWSFF GGYAPIPKLS SSTTQEQTQT
260 270 280 290 300
PCAELFWIDT KGNLHPTGTS SLDKDMLEKN KCYMLDCHSE VFVWMGRNTS
310 320 330 340 350
LTERKTSISS SEEFLRKEGR STTTSLVLLT EGLENARFRS FFNKWPQTVE
360 370 380 390 400
SSLYNEGREK VAALFKQKGY DVEELPDEED DPLYTNCRDN LKVWRVDGDD
410 420 430 440 450
VSLLSIPDQT KLFTGDCYLV QYKYTYKERT EHLLYVWIGC ESIQQDRADA
460 470 480 490 500
ITNASAIVGT TKGESVLCHI YQGNEPSRFF PMFQSLVVFK GGLSRRYKVL
510 520 530 540 550
LAEKEKIGEE YNENKASLFR VVGTSPRNMQ AIQVNLVATS LNSSYSYILQ
560 570 580 590 600
YGASAFTWIG KLSSDSDHEV LDRMLYFLDT SCQPIYIREG NETDTFWNLL
610 620 630 640 650
GGKSEYPKEK EMRKQIEEPH LFTCSCSSDV LKVKEIYNFV QDDLTTEDVF
660 670 680 690 700
LLDCQSEVYV WIGSNSNIKS KEEALTLGLK FLEMDILEEG LTMRTPVYVV
710 720 730 740 750
TEGHEPPFFT RFFEWVPEKA NMHGNSFERK LASLKGKKTS TKRSSGSQYR
760 770 780 790 800
SQSKDNASRD LQSRSVSSNG SERGVSPCSS EKLLSLSSAE DMTNSSNSTP
810 820 830 840 850
VVKKLFSESL LVDPNDGVAR QESSSKSDIS KQKPRVGINS DLSSLESLAY
860 870 880 890 900
SYEQLRVDSQ KPVTDIDATR REAYLTEKEF EERFGMAKSE FYALPKWKQN

KLKISLHLF
Length:909
Mass (Da):102,950
Last modified:May 15, 2007 - v2
Checksum:i4F04501BC4523FCC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8I → F in AAC31605 (PubMed:10631247).Curated1
Sequence conflicti347 – 353QTVESSL → SDRWSLAF in AAC31605 (PubMed:10631247).Curated7
Sequence conflicti585I → T in AAC31605 (PubMed:10631247).Curated1
Sequence conflicti811L → V in AAC31605 (PubMed:10631247).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081201 mRNA Translation: AAC31605.1
AC007113 Genomic DNA Translation: AAD23629.2
CP002685 Genomic DNA Translation: AEC08315.1
CP002685 Genomic DNA Translation: ANM61989.1
PIRiH84701
T50671
RefSeqiNP_001324173.1, NM_001336228.1 [O81643-1]
NP_029567.1, NM_128543.4 [O81643-1]
UniGeneiAt.11948

Genome annotation databases

EnsemblPlantsiAT2G29890.1; AT2G29890.1; AT2G29890 [O81643-1]
AT2G29890.5; AT2G29890.5; AT2G29890 [O81643-1]
GeneIDi817539
GrameneiAT2G29890.1; AT2G29890.1; AT2G29890 [O81643-1]
AT2G29890.5; AT2G29890.5; AT2G29890 [O81643-1]
KEGGiath:AT2G29890

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVILI1_ARATH
AccessioniPrimary (citable) accession number: O81643
Secondary accession number(s): O82367, Q9SIK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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