##gff-version 3
O81395	UniProtKB	Chain	1	521	.	.	.	ID=PRO_0000186358;Note=Bifunctional dihydrofolate reductase-thymidylate synthase	
O81395	UniProtKB	Domain	17	194	.	.	.	Note=DHFR	
O81395	UniProtKB	Region	197	521	.	.	.	Note=Thymidylate synthase	
O81395	UniProtKB	Active site	403	403	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	21	21	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	23	23	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	29	35	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	43	43	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	67	69	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	88	91	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	130	130	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	131	138	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	151	151	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	258	258	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	404	404	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	422	426	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	434	434	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O81395	UniProtKB	Binding site	464	466	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250