Reviewed, UniProtKB/Swiss-Prot O81372 (NDK1_MESCR)

Names and origin

Protein names

Recommended name:
    Nucleoside diphosphate kinase 1
    EC=2.7.4.6
Alternative name(s):
    Nucleoside diphosphate kinase I
      Short name=NDP kinase I
      Short name=NDPK I
      Short name=NDK I

Gene names

Name:

NDKP1

Organism

Mesembryanthemum crystallinum (Common ice plant)

Taxonomic identifier

3544 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › Caryophyllales › Aizoaceae › Mesembryanthemum

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the NDK family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic process Inferred from electronic annotation. Source: InterPro UTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 148	148	Nucleoside diphosphate kinase 1		PRO_0000137140
Sites
	Active site	115	1	Pros-phosphohistidine intermediate By similarity
	Binding site	9	1	ATP By similarity
	Binding site	57	1	ATP By similarity
	Binding site	85	1	ATP By similarity
	Binding site	91	1	ATP By similarity
	Binding site	102	1	ATP By similarity
	Binding site	112	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	O81372-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: BBDCF6304F481A3B	FASTA	148	16,351
	10 20 30 40 50 60 MEQTFIMIKP DGVQRGLVGE IISRFEKKGF SLKALKFINV DRPFAEKHYA DLSAKPFFNG 70 80 90 100 110 120 LVEYIVSGPV VAMVWEGKGV VLTGRKIIGA TNPLASEPGT IRGDFAIDIG RNVIHGSDAV 130 140 ESATKEIALW FPEGVVNWQS SLHSWIYE

References

[1]	"Nucleoside diphosphate kinase I from the common ice plant." Michalowski C.B., Bohnert H.J. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Root.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF072289 mRNA. Translation: AAC25999.1.
3D structure databases
SMR	O81372. Positions 1-148.
ModBase	Search...
Proteomic databases
PRIDE	O81372.
Enzyme and pathway databases
BRENDA	2.7.4.6. 2210.
Family and domain databases
InterPro	IPR001564. Nuc_diP_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.70.141. NDK. 1 hit.
PANTHER	PTHR11349. Nuc_diP_kinase_core. 1 hit.
Pfam	PF00334. NDK. 1 hit. [Graphical view]
PRINTS	PR01243. NUCDPKINASE.
SMART	SM00562. NDK. 1 hit. [Graphical view]
PROSITE	PS00469. NDP_KINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDK1_MESCR

Accession

Primary (citable) accession number: O81372

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	December 15, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)