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Protein

UDP-glucuronate 4-epimerase 3

Gene

GAE3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components.

Catalytic activityi

UDP-glucuronate = UDP-D-galacturonate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei242Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi92 – 123NADBy similarityAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandNAD

Enzyme and pathway databases

BRENDAi5.1.3.6 399

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronate 4-epimerase 3 (EC:5.1.3.6)
Alternative name(s):
UDP-glucuronic acid epimerase 3
Gene namesi
Name:GAE3
Ordered Locus Names:At4g00110
ORF Names:F6N15.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G00110
TAIRilocus:2126846 AT4G00110

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002925981 – 430UDP-glucuronate 4-epimerase 3Add BLAST430

Proteomic databases

PaxDbiO81312
PRIDEiO81312

Expressioni

Tissue specificityi

In roots, leaves, siliques, flowers, pollen and stems.2 Publications

Gene expression databases

ExpressionAtlasiO81312 baseline and differential
GenevisibleiO81312 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT4G00110.1

Structurei

3D structure databases

ProteinModelPortaliO81312
SMRiO81312
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi216 – 219Poly-Ser4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IU3F Eukaryota
COG0451 LUCA
HOGENOMiHOG000168000
InParanoidiO81312
KOiK08679
OMAiKFARWYL
OrthoDBiEOG09360AZR
PhylomeDBiO81312

Family and domain databases

InterProiView protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
IPR008089 Nuc_sugar_epim
PfamiView protein in Pfam
PF16363 GDP_Man_Dehyd, 1 hit
PRINTSiPR01713 NUCEPIMERASE
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

O81312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQMSHLDDI PSTPGKFKPY FHRTRWQSSV AKLAFWSLVF VGLIFIFFYR
60 70 80 90 100
SPVSSNPADP SRRSLRTYSW GGPAWEKRVR SSARLRTRRG FSVLVTGAAG
110 120 130 140 150
FVGTHVSAAL KRRGDGVLGL DNFNDYYDPS LKRARQALLE RSGVFVVEGD
160 170 180 190 200
INDAALLKKL FEVVPFTHVM HLAAQAGVRY AMENPSSYVH SNIAGFVNLL
210 220 230 240 250
EVCKSANPQP AIVWASSSSV YGLNTKVPFS EKDRTDQPAS LYAATKKAGE
260 270 280 290 300
EIAHTYNHIY GLSLTGLRFF TVYGPWGRPD MAYFFFTRDI LKGKAISIFE
310 320 330 340 350
GVNHGTVARD FTYIDDIVKG CLGALDTAEK STGSGGKKRG AAQLRVFNLG
360 370 380 390 400
NTSPVPVTDL VTILERLLKV KAKRNIMKLP RNGDVQFTHA NISSAQRELG
410 420 430
YKPTTDLQTG LKKFARWYLG YYNGGKKAAS
Length:430
Mass (Da):47,690
Last modified:November 1, 1998 - v1
Checksum:i0A57C1CB45BBAC02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069299 Genomic DNA Translation: AAC19298.1
AL161471 Genomic DNA Translation: CAB80769.1
CP002687 Genomic DNA Translation: AEE81824.1
BT026487 mRNA Translation: ABH04594.1
PIRiT01339
RefSeqiNP_191922.1, NM_116228.3
UniGeneiAt.27610

Genome annotation databases

EnsemblPlantsiAT4G00110.1; AT4G00110.1; AT4G00110
GeneIDi828145
GrameneiAT4G00110.1; AT4G00110.1; AT4G00110
KEGGiath:AT4G00110

Similar proteinsi

Entry informationi

Entry nameiGAE3_ARATH
AccessioniPrimary (citable) accession number: O81312
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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