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Protein

L-type lectin-domain containing receptor kinase IV.4

Gene

LECRK44

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici and to the pathogenic bacteria Pseudomonas syringae.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei379ATPPROSITE-ProRule annotation1
Active sitei475Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi356 – 364ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • defense response to bacterium Source: UniProtKB
  • defense response to oomycetes Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Plant defense

Keywords - Ligandi

ATP-binding, Lectin, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
L-type lectin-domain containing receptor kinase IV.41 Publication (EC:2.7.11.1PROSITE-ProRule annotation)
Short name:
LecRK-IV.41 Publication
Gene namesi
Name:LECRK441 Publication
Ordered Locus Names:At4g02420Imported
ORF Names:T14P8.4Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G02420.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 294ExtracellularSequence analysisAdd BLAST271
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 669CytoplasmicSequence analysisAdd BLAST354

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Increased susceptibility to the oomycetes Phytophthora brassicae and Phytophthora capsici and to the bacteria Pseudomonas syringae, characterized by stronger necrotic symptoms and higher bacterial proliferation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000040308824 – 669L-type lectin-domain containing receptor kinase IV.4Add BLAST646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO81291.
PRIDEiO81291.

Expressioni

Gene expression databases

GenevisibleiO81291. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G02420.1.

Structurei

3D structure databases

ProteinModelPortaliO81291.
SMRiO81291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini350 – 627Protein kinasePROSITE-ProRule annotationAdd BLAST278

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 260Legume-lectin likeSequence analysisAdd BLAST235

Sequence similaritiesi

In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Curated
In the N-terminal section; belongs to the leguminous lectin family.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEGM. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000116555.
InParanoidiO81291.
OMAiDTIMNIE.
OrthoDBiEOG0936040C.
PhylomeDBiO81291.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR031049. LecRK.
IPR001220. Legume_lectin_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR27007:SF13. PTHR27007:SF13. 1 hit.
PfamiPF00139. Lectin_legB. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O81291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFIKLFTIF FLSFFWQSLK SSSQIIDFTY NGFRPPPTDI SILGIATITP
60 70 80 90 100
NGLLKLTNTT MQSTGHAFYT KPIRFKDSPN GTVSSFSTTF VFAIHSQIPI
110 120 130 140 150
AHGMAFVIAP NPRLPFGSPL QYLGLFNVTN NGNVRNHVFA VELDTIMNIE
160 170 180 190 200
FNDTNNNHVG IDINSLNSVK SSPAGYWDEN DQFHNLTLIS SKRMQVWVDF
210 220 230 240 250
DGPTHLIDVT MAPFGEVKPR KPLVSIVRDL SSVLLQDMFV GFSSATGNIV
260 270 280 290 300
SEIFVLGWSF GVNGEAQPLA LSKLPRLPVW DLKPTRVYRF YKNWVPLISL
310 320 330 340 350
LLIPFLLIIF LVRFIMKRRR KFAEEVEDWE TEFGKNRLRF KDLYYATKGF
360 370 380 390 400
KDKNILGSGG FGSVYKGIMP KTKKEIAVKR VSNESRQGLK EFVAEIVSIG
410 420 430 440 450
QMSHRNLVPL VGYCRRRDEL LLVYDYMPNG SLDKYLYNSP EVTLDWKQRF
460 470 480 490 500
KVINGVASAL FYLHEEWEQV VIHRDVKASN VLLDAELNGR LGDFGLAQLC
510 520 530 540 550
DHGSDPQTTR VVGTWGYLAP DHIRTGRATT TTDVFAFGVL LLEVACGRRP
560 570 580 590 600
IEINNQSGER VVLVDWVFRF WMEANILDAK DPNLGSEYDQ KEVEMVLKLG
610 620 630 640 650
LLCSHSDPLA RPTMRQVLQY LRGDAMLPDL SPLDLRGSGI MLGTHNGSNE
660
SGMFTSGSSV AYSLLSSGR
Length:669
Mass (Da):75,399
Last modified:November 1, 1998 - v1
Checksum:i522142734DFAE0EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069298 Genomic DNA. Translation: AAC19274.1.
AL161494 Genomic DNA. Translation: CAB80735.1.
CP002687 Genomic DNA. Translation: AEE82168.1.
PIRiT01308.
RefSeqiNP_567234.1. NM_116475.2.
UniGeneiAt.65321.

Genome annotation databases

EnsemblPlantsiAT4G02420.1; AT4G02420.1; AT4G02420.
GeneIDi828035.
GrameneiAT4G02420.1; AT4G02420.1; AT4G02420.
KEGGiath:AT4G02420.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069298 Genomic DNA. Translation: AAC19274.1.
AL161494 Genomic DNA. Translation: CAB80735.1.
CP002687 Genomic DNA. Translation: AEE82168.1.
PIRiT01308.
RefSeqiNP_567234.1. NM_116475.2.
UniGeneiAt.65321.

3D structure databases

ProteinModelPortaliO81291.
SMRiO81291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G02420.1.

Proteomic databases

PaxDbiO81291.
PRIDEiO81291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G02420.1; AT4G02420.1; AT4G02420.
GeneIDi828035.
GrameneiAT4G02420.1; AT4G02420.1; AT4G02420.
KEGGiath:AT4G02420.

Organism-specific databases

TAIRiAT4G02420.

Phylogenomic databases

eggNOGiENOG410IEGM. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000116555.
InParanoidiO81291.
OMAiDTIMNIE.
OrthoDBiEOG0936040C.
PhylomeDBiO81291.

Miscellaneous databases

PROiO81291.

Gene expression databases

GenevisibleiO81291. AT.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR031049. LecRK.
IPR001220. Legume_lectin_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR27007:SF13. PTHR27007:SF13. 1 hit.
PfamiPF00139. Lectin_legB. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRK44_ARATH
AccessioniPrimary (citable) accession number: O81291
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.