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O81291

- LRK44_ARATH

UniProt

O81291 - LRK44_ARATH

Protein

L-type lectin-domain containing receptor kinase IV.4

Gene

LECRK44

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei379 – 3791ATPPROSITE-ProRule annotation
    Active sitei475 – 4751Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi356 – 3649ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. carbohydrate binding Source: InterPro
    3. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Lectin, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT4G02420-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-type lectin-domain containing receptor kinase IV.4 (EC:2.7.11.1)
    Short name:
    LecRK-IV.4
    Gene namesi
    Name:LECRK44
    Ordered Locus Names:At4g02420
    ORF Names:T14P8.4
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G02420.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 669646L-type lectin-domain containing receptor kinase IV.4PRO_0000403088Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO81291.
    PRIDEiO81291.

    Expressioni

    Gene expression databases

    GenevestigatoriO81291.

    Structurei

    3D structure databases

    ProteinModelPortaliO81291.
    SMRiO81291. Positions 15-261, 305-644.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 294271ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini316 – 669354CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei295 – 31521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini350 – 627278Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 260235Legume-lectin likeAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Curated
    In the N-terminal section; belongs to the leguminous lectin family.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000116555.
    InParanoidiO81291.
    OMAiWETAFGP.
    PhylomeDBiO81291.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR011009. Kinase-like_dom.
    IPR001220. Legume_lectin_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00139. Lectin_legB. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O81291-1 [UniParc]FASTAAdd to Basket

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    MFFIKLFTIF FLSFFWQSLK SSSQIIDFTY NGFRPPPTDI SILGIATITP    50
    NGLLKLTNTT MQSTGHAFYT KPIRFKDSPN GTVSSFSTTF VFAIHSQIPI 100
    AHGMAFVIAP NPRLPFGSPL QYLGLFNVTN NGNVRNHVFA VELDTIMNIE 150
    FNDTNNNHVG IDINSLNSVK SSPAGYWDEN DQFHNLTLIS SKRMQVWVDF 200
    DGPTHLIDVT MAPFGEVKPR KPLVSIVRDL SSVLLQDMFV GFSSATGNIV 250
    SEIFVLGWSF GVNGEAQPLA LSKLPRLPVW DLKPTRVYRF YKNWVPLISL 300
    LLIPFLLIIF LVRFIMKRRR KFAEEVEDWE TEFGKNRLRF KDLYYATKGF 350
    KDKNILGSGG FGSVYKGIMP KTKKEIAVKR VSNESRQGLK EFVAEIVSIG 400
    QMSHRNLVPL VGYCRRRDEL LLVYDYMPNG SLDKYLYNSP EVTLDWKQRF 450
    KVINGVASAL FYLHEEWEQV VIHRDVKASN VLLDAELNGR LGDFGLAQLC 500
    DHGSDPQTTR VVGTWGYLAP DHIRTGRATT TTDVFAFGVL LLEVACGRRP 550
    IEINNQSGER VVLVDWVFRF WMEANILDAK DPNLGSEYDQ KEVEMVLKLG 600
    LLCSHSDPLA RPTMRQVLQY LRGDAMLPDL SPLDLRGSGI MLGTHNGSNE 650
    SGMFTSGSSV AYSLLSSGR 669
    Length:669
    Mass (Da):75,399
    Last modified:November 1, 1998 - v1
    Checksum:i522142734DFAE0EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF069298 Genomic DNA. Translation: AAC19274.1.
    AL161494 Genomic DNA. Translation: CAB80735.1.
    CP002687 Genomic DNA. Translation: AEE82168.1.
    PIRiT01308.
    RefSeqiNP_567234.1. NM_116475.1.
    UniGeneiAt.65321.

    Genome annotation databases

    EnsemblPlantsiAT4G02420.1; AT4G02420.1; AT4G02420.
    GeneIDi828035.
    KEGGiath:AT4G02420.

    Cross-referencesi

    Web resourcesi

    PlantP kinase Classification PPC

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF069298 Genomic DNA. Translation: AAC19274.1 .
    AL161494 Genomic DNA. Translation: CAB80735.1 .
    CP002687 Genomic DNA. Translation: AEE82168.1 .
    PIRi T01308.
    RefSeqi NP_567234.1. NM_116475.1.
    UniGenei At.65321.

    3D structure databases

    ProteinModelPortali O81291.
    SMRi O81291. Positions 15-261, 305-644.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi O81291.
    PRIDEi O81291.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G02420.1 ; AT4G02420.1 ; AT4G02420 .
    GeneIDi 828035.
    KEGGi ath:AT4G02420.

    Organism-specific databases

    GeneFarmi 171. 4.
    TAIRi AT4G02420.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000116555.
    InParanoidi O81291.
    OMAi WETAFGP.
    PhylomeDBi O81291.

    Enzyme and pathway databases

    BioCyci ARA:AT4G02420-MONOMER.

    Gene expression databases

    Genevestigatori O81291.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR011009. Kinase-like_dom.
    IPR001220. Legume_lectin_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00139. Lectin_legB. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. Cited for: GENE FAMILY.
    4. "Arabidopsis L-type lectin receptor kinases: phylogeny, classification, and expression profiles."
      Bouwmeester K., Govers F.
      J. Exp. Bot. 60:4383-4396(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiLRK44_ARATH
    AccessioniPrimary (citable) accession number: O81291
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3